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    사람 프로유로키나제를 생산하는 형질전환 복제 소 및 이의 생산 방법
    1.
    发明公开
    사람 프로유로키나제를 생산하는 형질전환 복제 소 및 이의 생산 방법 有权
    转基因克隆生产人类免疫球蛋白及其生产方法

    公开(公告)号：KR1020040016426A

    公开(公告)日：2004-02-21

    申请号：KR1020030056629

    申请日：2003-08-14

    Applicant: 재단법인서울대학교산학협력재단

    Inventor： 황우석 ,  이병천 ,  강성근 ,  정의배 ,  조종기 ,  우딘 ,  김순웅 ,  박을순 ,  장구 ,  박정수 ,  김성기

    IPC: C12N5/16

    CPC classification number: A01K67/0273 ,  A01K67/0275 ,  A01K2227/101 ,  A01K2267/01 ,  C12N9/6456 ,  C12N15/8509 ,  C12N15/8771 ,  C12N2830/008

    Abstract: PURPOSE: A transgenic cloned cow producing human prourokinase and a method for producing the same are provided, thereby expressing human prourokinase from the mammary gland of the transgenic cloned cow, and easily separating it from milk. CONSTITUTION: Provided is a nucleus transplanted ovum wherein a nucleus of a somatic cell derived from a cow and containing a human prourokinase gene is fused with a nucleus removed ovum derived from cow. The nucleus transplanted ovum is SNU-B1(KCTC 10286BP). A method for producing the nucleus transplanted ovum comprises the steps of: (a) introducing a human prourokinase gene into the somatic cell derived from cow to prepare a nucleus transferring cell; (b) removing a cumulus cell and cytoplasm from a ovum of a cow to prepare a nucleus receiving ovum; and (c) transplanting the nucleus transferring cell into the nucleus receiving ovum and fusing them.

    Abstract translation: 目的：提供产生人类原尿激酶的转基因克隆牛及其生产方法，从而从转基因克隆牛的乳腺中表达人类原尿激酶，并且容易地将它与牛分离。 构成：提供了一种移植卵的细胞核，其中源自牛的体细胞细胞核并含有人类原尿激酶基因与从牛获得的去除卵的细胞核融合。 移植的卵细胞为SNU-B1（KCTC 10286BP）。 用于产生移植卵的细胞的方法包括以下步骤：（a）将人类原尿激酶基因导入来自牛的体细胞，制备细胞核转移细胞; （b）从牛的卵中除去卵丘细胞和细胞质以制备接受卵的细胞核; 和（c）将细胞核转移细胞移植到接受卵子的细胞核中并融合它们。

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