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    2축 배향성을 갖는 금속 선재를 제조하기 위한 시스템 및방법
    4.
    发明公开
    2축 배향성을 갖는 금속 선재를 제조하기 위한 시스템 및방법 失效
    用于制作具有双重对准性的金属线条的系统和方法

    公开(公告)号：KR1020070073315A

    公开(公告)日：2007-07-10

    申请号：KR1020060001071

    申请日：2006-01-04

    Applicant: 재단법인서울대학교산학협력재단

    Inventor： 김철진 ,  정준기 ,  김석환 ,  박찬 ,  유상임

    IPC: C21D1/00 ,  B21B1/16

    CPC classification number: C21D1/00 ,  B21B2001/022 ,  C21D1/74 ,  C21D2201/04 ,  C22F1/10

    Abstract: A system and a method for manufacturing a superconductor wire which can improve structure degree of texture with biaxial-alignment property, and a system and a method for manufacturing a superconductor wire having excellent crystal arrangement characteristics at low cost are provided. A method for manufacturing a metal wire comprises: a step of manufacturing a billet; a step of manufacturing a metal tape from the billet using a rolling process; and a step(S4) of recrystallizing the metal tape in a reductive atmosphere, wherein the metal tape recrystallizing step comprises a step of applying a predetermined magnetic field to the metal tape. The metal tape recrystallizing step comprises the step of performing one cycle of heat treatment process multiple times, wherein the one cycle of heat treatment process comprises: a step(S41) of applying a predetermined magnetic field to the metal tape at the Curie temperature or less; a step(S42) of applying a predetermined magnetic field to the metal tape while heating the metal tape to the Curie temperature or more; and a step(S43) of applying a predetermined magnetic field to the metal tape while rapidly cooling the metal tape to the Curie temperature or less.

    Abstract translation: 提供了一种可以提高双轴取向特性的结构质地的超导体线的制造方法和制造具有优异的晶体排列特性的超导线的系统和方法。 金属丝的制造方法包括：制造坯料的工序; 使用轧制方法从坯料制造金属带的步骤; 以及在还原气氛中使金属带再结晶的步骤（S4），其中金属带再结晶步骤包括向金属带施加预定磁场的步骤。 金属带再结晶步骤包括多次执行一个循环的热处理工艺的步骤，其中热处理工艺的一个循环包括：步骤（S41），以居里温度或更低的温度向金属带施加预定的磁场 ; 在将金属带加热到居里温度以上的同时向金属带施加预定磁场的步骤（S42）; 以及在将金属带快速冷却至居里温度以下的同时向金属带施加预定磁场的步骤（S43）。

    신규한 디아민디티올 유도체 및 그의 방사성 레늄 또는방사성 테크네슘 착체； 그리고, 그의 방사성 레늄 착체와리피오돌을 포함하는 간암 치료용 조성물 및 그의 제조용키트
    7.
    发明公开
    신규한 디아민디티올 유도체 및 그의 방사성 레늄 또는방사성 테크네슘 착체； 그리고, 그의 방사성 레늄 착체와리피오돌을 포함하는 간암 치료용 조성물 및 그의 제조용키트 有权
    新型DIAMINEDITHIOL衍生物，放射性铑或其复合物，用于治疗含有铑复合物和LIPIODOL的肝癌的组合物和用于制备的试剂盒

    公开(公告)号：KR1020020074239A

    公开(公告)日：2002-09-30

    申请号：KR1020010013987

    申请日：2001-03-19

    Applicant: 재단법인서울대학교산학협력재단

    Inventor： 정재민 ,  김영주 ,  이윤상 ,  이동수 ,  정준기 ,  이명철

    IPC: C07C381/00

    CPC classification number: C07D285/00 ,  C07C323/41 ,  C07F13/005 ,  Y02P20/55

    Abstract: PURPOSE: A novel diaminedithiol derivative and its pharmaceutically acceptable salt, a radioactive complex of the derivative, a composition for the treatment of liver cancer and a kit for the preparation of the composition and the complex are provided, to improve the stability of the complex in lipiodol media, thereby allowing the accumulation rate of the composition in the liver cancer tissue to be increased and reducing the side-effect. CONSTITUTION: The diaminedithiol derivative and its pharmaceutically acceptable salt is represented by the formula, R2 to R14 are H or an alkyl group of C1-C5, or R4 and R5, A6 and R7, R8 and R9, and R11 and R12 can be oxo group (=O), respectively, and at least one among the groups is an alkyl group of C6-C24; R1 and R15 are H, or a thiol protecting group comprising benzoyl group, acetamidomethyl group, diphenylmethyl group, ethylaminocarbonyl group, t-butyl group, trityl group, and acetyl group, or R1 and R15 form S-S bond together; and n, p, and o are 1 or 2, respectively. The complex comprises the diaminedithiol derivative and a radioactive rhenium or technetium. The composition for the treatment of liver cancer comprises the complex of the diaminedithiol derivative and lipiodol.

    Abstract translation: 目的：提供新型二硫代二醇衍生物及其药学上可接受的盐，衍生物的放射性复合物，用于治疗肝癌的组合物和用于制备组合物和复合物的试剂盒，以提高复合物的稳定性 碘油介质，从而允许肝癌组织中组合物的积累速率增加并降低副作用。 构成：二硫代二硫醇衍生物及其药学上可接受的盐由下式表示：R 2至R 14为H或C 1 -C 5烷基或R 4和R 5，A 6和R 7，R 8和R 9，R 11和R 12可以是氧代 基团（= O），并且这些基团中的至少一个是C 6 -C 24的烷基; R 1和R 15为H，或含有苯甲酰基，乙酰氨基甲基，二苯基甲基，乙基氨基羰基，叔丁基，三苯甲基和乙酰基的硫醇保护基，或R 1和R 15一起形成S-S键; 而n，p和o分别为1或2。 络合物包括二硫二硫醇衍生物和放射性铼或锝。 用于治疗肝癌的组合物包括二硫代二醇衍生物和碘油的复合物。

    베타아밀로이드 펩타이드 플라크의 영상화를 위한벤질리덴아닐린 계열의 유도체 및 그의 방사성 동위원소표지화합물
    8.
    发明公开
    베타아밀로이드 펩타이드 플라크의 영상화를 위한벤질리덴아닐린 계열의 유도체 및 그의 방사성 동위원소표지화합물 失效
    苄基苯胺衍生物及其用于β型甲醛溶液的结合和成像的放射性标记化合物

    公开(公告)号：KR1020070056421A

    公开(公告)日：2007-06-04

    申请号：KR1020050115012

    申请日：2005-11-29

    Applicant: 재단법인서울대학교산학협력재단

    Inventor： 정재민 ,  이동수 ,  정준기 ,  이명철

    IPC: C07C251/24

    CPC classification number: A61K51/04 ,  C07C251/24

    Abstract: Provided are a benzylideneaniline derivative for imaging beta-amyloid peptide plaques to diagnose or treat the disease derived from beta-amyloid peptide plaques such as Alzheimer's disease, a pharmaceutical composition for injection containing the derivative, and a method for preparing a 18F-labeled benzylideneaniline derivative. The benzylideneaniline derivative is represented by a formula 1, wherein R1 to R5 are independently H, a C1-C4 alkyl group or F, but at least one among R1 to R5 is F; and R6 to R10 are independently H, a C1-C4 alkyl group, OH, OCH3, NH2, NHCH3 or N(CH3)2, but at least one among R6 to R10 is OH, OCH3, NH2, NHCH3 or N(CH3)2.

    Abstract translation: 提供了用于成像β-淀粉样蛋白肽斑块的亚苄基苯胺衍生物，用于诊断或治疗衍生自β-淀粉样蛋白肽斑块如阿尔茨海默氏病的疾病，含有该衍生物的注射用药物组合物和制备18F-标记的亚苄基苯胺衍生物的方法 。 亚苄基苯胺衍生物由式1表示，其中R 1至R 5独立地为H，C 1 -C 4烷基或F，但R 1至R 5中的至少一个为F; R 6至R 10独立地为H，C 1 -C 4烷基，OH，OCH 3，NH 2，NHCH 3或N（CH 3）2，但R 6至R 10中的至少一个为OH，OCH 3，NH 2，NHCH 3或N（CH 3） 2。

    베타아밀로이드 침착의 영상화를 위한 헤테로사이클릭 인덴계열의 유도체 및 그의 방사성 동위원소 표지화합물
    9.
    发明公开
    베타아밀로이드 침착의 영상화를 위한 헤테로사이클릭 인덴계열의 유도체 및 그의 방사성 동위원소 표지화합물 有权
    杂环衍生物及其放射性标记化合物用于成像BET-淀粉沉积

    公开(公告)号：KR1020080105766A

    公开(公告)日：2008-12-04

    申请号：KR1020070053777

    申请日：2007-06-01

    Applicant: 재단법인서울대학교산학협력재단

    Inventor： 정재민 ,  이동수 ,  정준기 ,  이명철

    IPC: C07D263/57 ,  C07D277/66

    CPC classification number: C07D307/87 ,  A61K51/0419 ,  A61K51/0431 ,  A61K51/0453 ,  C07D263/57 ,  C07D277/66 ,  C07D333/72

    Abstract: A heterocyclic indene derivative, a radioactive isotope labeled compound of the derivative, a method for preparing the radioactive isotope labeled compound, and a composition for the beta-amyloid imaging containing the radioactive isotope labeled compound are provided to allow a radioactive isotope to be labeled easily, to improve the initial brain absorption and to enhance the disappearance at normal brain. A heterocyclic indene derivative is represented by the formula 1, wherein X is O, S or NH; Y is CH or N; Z is F, Cl, Br, I or a sulfonic acid derivative; and R1 to R8 are independently H, a C1-C4 alkyl group, F, Cl, Br, I, O-CH3, O-CH2-CH3, O-CH2=CH2-CH3 or OH.

    Abstract translation: 提供杂环茚衍生物，衍生物的放射性同位素标记化合物，制备放射性同位素标记化合物的方法和含有放射性同位素标记化合物的β-淀粉样成像组合物，以允许放射性同位素易于标记 ，以改善初始脑吸收并增强正常大脑的消失。 杂环茚衍生物由式1表示，其中X是O，S或NH; Y是CH或N; Z是F，Cl，Br，I或磺酸衍生物; 且R 1至R 8独立地为H，C 1 -C 4烷基，F，Cl，Br，I，O-CH 3，O-CH 2 -CH 3，O-CH 2 = CH 2 -CH 3或OH。

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