-
公开(公告)号：KR101480393B1
公开(公告)日：2015-01-09
申请号：KR1020120114202
申请日：2012-10-15
Applicant: 전남대학교병원
Abstract: 본 발명은 간암 진단을 위한 조영제용 가돌리늄 착물과 이의 제조방법 그리고 이를 이용한 간암 진단용 조영제에 관한 것으로서, 더욱 상세하게는 히알루론산을 이용하여 T1 조영효과가 있는 가돌리늄을 간세포에 효과적으로 전달하여 조영능력을 향상시킬 수 있는 조영제용 가돌리늄 착물과 이의 제조방법 그리고 이를 이용한 간암 진단용 조영제에 관한 것이다.
본 발명의 가돌리늄 착물은 다이에틸렌트리아민펜타아세트산(diethylene triamine pentaacetic acid, DTPA)과 히알루론산(hyaluronic acid, HA)을 반응시켜 형성된 DTPA-HA 중간물질에 가돌리늄(gadolinium, Gd)이 결합된 것을 특징으로 한다.-
公开(公告)号：KR1020130103396A
公开(公告)日：2013-09-23
申请号：KR1020130024276
申请日：2013-03-07
Applicant: 전남대학교병원
CPC classification number: A61K49/1863 , A61K49/08 , A61K49/1875 , B82Y40/00
Abstract: PURPOSE: A magnetic resonance imaging (MRI) contrast agent coated with beta-glucan is provided to effectively allow immunocytes to enter, thereby distinguishing a lesion and a normal tissue in a tissue containing immunocytes through MRI. CONSTITUTION: A method for manufacturing MRI contrast agent comprises the steps of: synthesizing superparamagnetic nanoparticles; oxidizing and dialyzing the superparamagnetic nanoparticles and preparing a superparamagnetic storage solution; diluting the storage solution with distilled water and dropping a beta-glucan solution at 1-10°C; and adding a basic solution to the reactant and adjusting the pH concentration of the reactant.
Abstract translation: 目的：提供涂有β-葡聚糖的磁共振成像（MRI）造影剂，以有效地使免疫细胞进入，从而通过MRI区分含有免疫细胞的组织中的病变和正常组织。 构成：制造MRI造影剂的方法包括以下步骤：合成超顺磁性纳米粒子; 氧化和透析超顺磁性纳米颗粒并制备超顺磁性储存溶液; 用蒸馏水稀释储存溶液，并在1-10℃下滴加β-葡聚糖溶液; 并向反应物中加入碱性溶液并调节反应物的pH浓度。
-
公开(公告)号：KR1020130040163A
公开(公告)日：2013-04-23
申请号：KR1020120114202
申请日：2012-10-15
Applicant: 전남대학교병원
CPC classification number: A61K49/1863 , A61K49/105 , A61K49/122 , Y10S607/901
Abstract: PURPOSE: A gadolinium complex for a contrast agent for diagnosing liver cancer is provided to effectively deliver gadolinium to a liver cell and to improve contrasting ability. CONSTITUTION: A gadolinium complex for a contrast agent for diagnosing liver cancer contains gadolinium(Gd) which is conjugated to a DTPA-HA intermediate material which is formed by reaction of DTPA(diethylene triamine pentaacetic acid) with HA(hyaluronic acid). The DTPA-HA intermediate is denoted by chemical formula 1. A method for preparing the gadolinium complex comprises: a step of reacting DTPA(diethylene triamine pentaacetic acid) with hyaluronic acid(HA) in an organic solvent and generating the DTPA-HA intermediate; and a step of binding gadolinium to the DTPA-HA intermediate. A contrast agent for diagnosing liver cancer contains the gadolinium complex.
Abstract translation: 目的：提供用于诊断肝癌的造影剂的钆络合物，以有效地将钆输送到肝细胞并提高对比能力。 构成：用于诊断肝癌的造影剂的钆络合物含有与DTPA（二亚乙基三胺五乙酸）与HA（透明质酸）反应形成的DTPA-HA中间体材料结合的钆（Gd）。 DTPA-HA中间体由化学式1表示。制备钆络合物的方法包括：使DTPA（二亚乙基三胺五乙酸）与透明质酸（HA）在有机溶剂中反应并产生DTPA-HA中间体的步骤; 以及将钆结合到DTPA-HA中间体的步骤。 用于诊断肝癌的造影剂含有钆络合物。
-
-
Search Results
3
records
(took 0.017 seconds)
