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1.发明授权
公开(公告)号：KR100960684B1
公开(公告)日：2010-05-31
申请号：KR1020080016505
申请日：2008-02-22
Applicant: 전남대학교산학협력단
CPC classification number: C07K14/705 , A01K67/0275 , A01K2217/052 , A01K2227/105 , A01K2267/0331 , A61K48/00 , C12N15/8509
Abstract: 본 발명은 TREM-2(Triggering Receptor Expressed on Myeloid cells-2) 유전자 또는 단백질을 포함하는 GA733-2 항원의 발현 억제 또는 검출용 조성물 및 방법, 및 이를 포함하는 형질전환 동물, 특히 형질전환 마우스 및 이의 사용방법에 관한 것으로서, 암, 특히 대장암의 원인 규명은 물론 그의 진단, 특히 조기진단 및 치료제 개발에 크게 기여할 수 있다.
TREM-2, GA733-2, 암, 대장암, 형질전환, 동물 모델, 마우스-
公开(公告)号：KR1020070030155A
公开(公告)日：2007-03-15
申请号：KR1020060109706
申请日：2006-11-07
Applicant: 전남대학교산학협력단 , 주식회사 굿셀라이프
IPC: C12N5/0783 , A61K35/17 , C12N9/12
CPC classification number: C12N5/0646 , A61K35/17 , C12N9/12
Abstract: A composition for differentiation of a mature natural killer(NK) cell and a method for production of the same mature natural killer cell are provided to produce a large quantity of mature natural killer cell to increase cancer-killing effects of the mature natural killer cell. The composition for differentiation of the mature natural killer cell from a precursor natural killer cell(pNK) comprises a ligand of Axl receptor tyrosine kinase. The method for producing the mature natural killer cell comprises the steps of: treating a hematopoietic stem cell with IL-7(interleukine 7), SCF(stem cell factor) and Flt3L(fms-related tyrosine kinase 3 ligand) to differentiate the hematopoietic stem cell into a precursor natural killer cell; and treating the precursor natural killer cell with the ligand of Axl receptor tyrosine kinase, wherein the mature killer cell is useful for treatment of cancers including large intestine cancer, breast cancer, non-Hodgikin's lymphoma and acute ymphocytic leukemia.
Abstract translation: 提供用于分化成熟天然杀伤（NK）细胞的组合物和用于生产相同成熟天然杀伤细胞的方法以产生大量的成熟天然杀伤细胞以增加成熟天然杀伤细胞的杀死癌症效果。 成熟天然杀伤细胞从前体天然杀伤细胞（pNK）分化的组合物包含Ax1受体酪氨酸激酶的配体。 用于生产成熟天然杀伤细胞的方法包括以下步骤：用IL-7（白细胞介素7），SCF（干细胞因子）和Flt3L（fms相关的酪氨酸激酶3配体）处理造血干细胞以分化造血干细胞 细胞成为前体天然杀伤细胞; 并用Ax1受体酪氨酸激酶的配体处理前体天然杀伤细胞，其中成熟的杀伤细胞可用于治疗包括大肠癌，乳腺癌，非霍奇金淋巴瘤和急性淋巴细胞性白血病的癌症。
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公开(公告)号：KR1020070030114A
公开(公告)日：2007-03-15
申请号：KR1020060067483
申请日：2006-07-19
Applicant: 전남대학교산학협력단
Abstract: A method for production of natural killer(NK) cells is provided to treat cancers without side effects using the natural killer cells by using an Axl gene capable of promoting differentiation from hematopoietic stem cells into natural killer cells. The adult natural killer cells are produced by treating hematopoietic stem cells with IL-7(interleukine 7), SCF(stem cell factor) and Flt3L(fms-related tyrosine kinase 3 ligand), so as to differentiate them into NK precursor cells, and treating the NK precursor cells with the Axl gene, wherein the hematopoietic stem cells are isolated from human cord blood. A recombinant vector pLXSN-Axl contains the Axl gene. A transformant is produced by transforming a host cell, mouse RAW264.7 macrophage, with the recombinant vector pLXSN-Axl.
Abstract translation: 提供了一种生产天然杀伤（NK）细胞的方法，通过使用能促进从造血干细胞分化成自然杀伤细胞的Axl基因，使用天然杀伤细胞治疗无副作用的癌症。 通过用IL-7（白介素7），SCF（干细胞因子）和Flt3L（fms相关的酪氨酸激酶3配体）处理造血干细胞来产生成年自然杀伤细胞，以将它们分化成NK前体细胞，以及 用Axl基因处理NK前体细胞，其中从人脐血分离造血干细胞。 重组载体pLXSN-Ax1含有Axl基因。 通过用重组载体pLXSN-Ax1转化宿主细胞小鼠RAW264.7巨噬细胞来产生转化体。
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公开(公告)号：KR1020130072034A
公开(公告)日：2013-07-01
申请号：KR1020110139578
申请日：2011-12-21
Applicant: 전남대학교산학협력단
CPC classification number: Y02E10/542 , Y02P70/521 , C09B61/00 , H01G9/2059 , H01L31/042
Abstract: PURPOSE: A manufacturing method of a natural dye solution is provided to provide a natural dye solution capable of manufacturing various natural dye-sensitive solar batteries for requiring growth of plants. CONSTITUTION: A manufacturing method of a natural dye solution comprises a step of preparing a natural dye powder (400); a step of forming a natural dye solution by mixing the natural dye powder, pH controller, and solvent; and a step of forming a natural dye solution by mixing the natural dye powder, pH controller, and solvent. The natural dye solution has a wavelength selectivity for promoting or inhibiting growth of plant. The natural dye is Carthami Flos xanthophyll, lac color, alive side, red cabbage pigment, gardenia red, gardenia blue, rdenia Yellow, cacao, cochineal, henna, or monascus red. The manufacturing method is provided to control wavelength range by using the pH controller.
Abstract translation: 目的：提供天然染料溶液的制造方法，以提供能够制造各种需要植物生长的天然染料敏感型太阳能电池的天然染料溶液。 构成：天然染料溶液的制造方法包括制备天然染料粉末（400）的步骤; 通过混合天然染料粉末，pH控制剂和溶剂形成天然染料溶液的步骤; 以及通过混合天然染料粉末，pH调节剂和溶剂形成天然染料溶液的步骤。 天然染料溶液具有促进或抑制植物生长的波长选择性。 天然染料是Carthami Flos xanthophyll，lac颜色，活着的侧面，红色的白菜色素，栀子红，栀子蓝，rdenia黄，可可，胭脂红，指甲花或红曲红。 提供了通过使用pH控制器来控制波长范围的制造方法。
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公开(公告)号：KR1020070078561A
公开(公告)日：2007-08-01
申请号：KR1020060008941
申请日：2006-01-27
Applicant: 주식회사 굿셀라이프 , 전남대학교산학협력단
IPC: C07K19/00 , C07K14/195 , C07K14/245
CPC classification number: C07K14/005 , A61K39/12 , A61K47/62 , C07K14/245 , C07K2319/00 , C12N15/70 , C12N2510/02 , C12N2710/20034
Abstract: A chimeric protein consisting of nontoxic CTB(cholera toxin B subunit) of Vibrio cholerae and HPV16 E7(human papilloma virus type 16 E7) protein and use thereof are provided to induce an antibody specific to HPV16 E7 and simultaneously induce mucosa immune response for promoting mucosa permeability of the antibody, so that the protein is useful as an effective ingredient of a vaccine for preventing and treating cervical cancer. The chimeric protein consisting of nontoxic CTB of Vibrio cholerae whose signal peptide region is deleted, and HPV16 E7 protein has the amino acid sequence of SEQ ID NO:6. A gene encoding the chimeric protein has the nucleotide sequence of SEQ ID NO:5. A method for producing the chimeric protein comprises the steps of: constructing a recombinant vector E7-CTB/pET29a containing the chimeric gene; transforming Escherichia coli with the vector to produce E. coli BL21(DE3):E7-CTB/pET29a(KCTC 10894BP); culturing the transformed E. coli; and separating the chimeric protein from the cultured E. coli, and purifying and removing endotoxin from the chimeric protein.
Abstract translation: 提供由霍乱弧菌无毒CTB（霍乱毒素B亚基）和HPV16 E7（人乳头瘤病毒16型E7）蛋白组成的嵌合蛋白及其用途，以诱导对HPV16 E7特异性的抗体，同时诱导促进粘膜的粘膜免疫应答 抗体的渗透性，使得该蛋白质可用作预防和治疗子宫颈癌的疫苗的有效成分。 由信号肽区域缺失的霍乱弧菌无毒CTB组成的嵌合蛋白质和HPV16E7蛋白质具有SEQ ID NO：6的氨基酸序列。 编码嵌合蛋白的基因具有SEQ ID NO：5的核苷酸序列。 制备嵌合蛋白的方法包括以下步骤：构建含嵌合基因的重组载体E7-CTB / pET29a; 用载体转化大肠杆菌以产生大肠杆菌BL21（DE3）：E7-CTB / pET29a（KCTC 10894BP）; 培养转化的大肠杆菌; 并从培养的大肠杆菌中分离嵌合蛋白质，并从嵌合蛋白质中纯化和去除内毒素。
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Patent Agency Ranking
公开(公告)号：KR1020070078560A
公开(公告)日：2007-08-01
申请号：KR1020060008940
申请日：2006-01-27
Applicant: 주식회사 굿셀라이프 , 전남대학교산학협력단
CPC classification number: C07K14/005 , A61K39/12 , A61K47/62 , C07K14/28 , C07K2319/00 , C12N15/63 , C12N2510/02 , C12N2710/20034
Abstract: A chimeric protein consisting of nontoxic CTB(cholera toxin B subunit) of Vibrio cholerae and HPV16 E6(human papilloma virus type 16 E6) protein and use thereof are provided to produce vaccine effectively absorbed to a mucosa for preventing and treating cervical cancer by using cervical cancer treating effects of HPV16 E6 protein and mucosa-penetrating ability of CTB. The chimeric protein consists of nontoxic CTB(cholera toxin B subunit) of Vibrio cholerae wherein the signal peptide region is deleted to remove toxicity, and HPV16 E6 protein, has the amino acid sequence of SEQ ID NO:6, is encoded by a gene having the nucleotide sequence of SEQ ID NO:5, and is produced by preparing a vector E6-CTB/pET29a containing the chimeric protein gene, transforming Escherichia coli with the vector to produce Escherichia coli BL21:E6-CTB/pET29a(KCTC 10892BP), culturing Escherichia coli BL21:E6-CTB/pET29a(KCTC 10892BP), separating the chimeric protein from the cultured transformed microorganism and removing endotoxin from the separated chimeric protein.
Abstract translation: 提供由霍乱弧菌无毒CTB（霍乱毒素B亚单位）和HPV16 E6（人乳头瘤病毒16型E6）蛋白组成的嵌合蛋白及其用途，以产生有效吸收到粘膜以预防和治疗宫颈癌的疫苗，方法是使用子宫颈 HPV16 E6蛋白的癌症治疗效果和CTB的粘膜穿透能力。 嵌合蛋白由霍乱弧菌的无毒CTB（霍乱毒素B亚基）组成，其中信号肽区缺失以消除毒性，HPV16E6蛋白具有SEQ ID NO：6的氨基酸序列，由具有SEQ ID NO：6的基因编码， SEQ ID NO：5的核苷酸序列，通过制备含有嵌合蛋白质基因的载体E6-CTB / pET29a，用载体转化大肠杆菌来产生大肠杆菌BL21：E6-CTB / pET29a（KCTC 10892BP）， 培养大肠杆菌BL21：E6-CTB / pET29a（KCTC 10892BP），从培养的转化微生物中分离嵌合蛋白质，并从分离的嵌合蛋白中除去内毒素。
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7.发明公开
公开(公告)号：KR1020070078559A
公开(公告)日：2007-08-01
申请号：KR1020060008939
申请日：2006-01-27
Applicant: 주식회사 굿셀라이프 , 전남대학교산학협력단
IPC: C07K19/00 , C07K14/025 , C07K14/245
CPC classification number: C07K14/005 , A61K39/12 , C07K14/245 , C07K2319/00 , C12N15/70 , C12N2510/02
Abstract: A chimeric protein consisting of LTB(Escherichia coli heat-labile enterotoxin B subunit) and HPV16 E6(human papilloma virus type 16 E6) protein and use thereof are provided to induce an antibody specific to HPV16 E6 protein and mucosal immune response simultaneously, so that the chimeric protein is useful for production of a vaccine for preventing and treating cervical cancer. The chimeric protein consisting of LTB wherein the signal peptide region is deleted and HPV16 E6 protein has the amino acid sequence of SEQ ID NO:6 and is encoded by a gene having the nucleotide sequence of SEQ ID NO:5. A vector E6-LTB/pET29a contains the chimeric protein gene and is used for production of a transformed Escherichia coli BL21:E6-LTB/pET29a(KCTC 10893BP). The chimeric protein consisting of LTB and HPV16 E6 protein is produced by culturing the transformed Escherichia coli BL21:E6-LTB/pET29a(KCTC 10893BP), separating the chimeric protein from the cultured transformed microorganism and removing endotoxin from the separated chimeric protein.
Abstract translation: 提供由LTB（大肠杆菌热不稳定肠毒素B亚基）和HPV16 E6（人乳头瘤病毒16型E6）蛋白组成的嵌合蛋白及其用途，以同时诱导HPV16E6蛋白特异性抗体和粘膜免疫应答，从而 该嵌合蛋白质可用于生产用于预防和治疗子宫颈癌的疫苗。 由LTB组成的嵌合蛋白，其中信号肽区被缺失，HPV16E6蛋白具有SEQ ID NO：6的氨基酸序列，并由具有SEQ ID NO：5的核苷酸序列的基因编码。 载体E6-LTB / pET29a含有嵌合蛋白基因，用于生产转化大肠杆菌BL21：E6-LTB / pET29a（KCTC 10893BP）。 通过培养转化的大肠杆菌BL21：E6-LTB / pET29a（KCTC 10893BP），从培养的转化微生物中分离嵌合蛋白质并从分离的嵌合蛋白质中除去内毒素，产生由LTB和HPV16 E6蛋白组成的嵌合蛋白质。
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公开(公告)号：KR1020070030115A
公开(公告)日：2007-03-15
申请号：KR1020060067485
申请日：2006-07-19
Applicant: 전남대학교산학협력단
Abstract: A method for production of a natural killer(NK) cell is provided to avoid side effects in cancer therapy by using a natural killer cell differentiated from a hematopoietic stem cell instead of a matured natural killer cell. The adult natural killer cell is produced by treating the hematopoietic stem cell with IL-7(interleukine 7), SCF(stem cell factor) and Flt3L(fms-related tyrosine kinase 3 ligand) to differentiate the hematopoietic stem cell into a NK precursor cell, and treating the NK precursor cell with the Axl receptor and its ligand Gas6. The hematopoietic stem cell is isolated from the human cord blood; the Axl is a recombinant Axl produced from a transformant containing a recombinant vector pLXSN-Axl; the host cell of the transformant containing the recombinant vector pLXSN-Axl is a mouse RAW264.7 macrophage; the recombinant Gas6 is produced from a transformant containing a recombinant vector pcDNA3.1(+)-GAS6; and the host cell of the transformant containing the recombinant vector pcDNA3.1(+)-GAS6 is a mouse OP9 cell line.
Abstract translation: 提供了一种生产自然杀伤（NK）细胞的方法，以通过使用从造血干细胞分化而不是成熟的天然杀伤细胞分化的天然杀伤细胞来避免癌症治疗中的副作用。 通过用IL-7（白细胞介素7），SCF（干细胞因子）和Flt3L（fms相关的酪氨酸激酶3配体）处理造血干细胞以将造血干细胞分化成NK前体细胞来产生成年自然杀伤细胞 ，并用Ax1受体及其配体Gas6处理NK前体细胞。 造血干细胞从人脐带血中分离出来; Ax1是由含有重组载体pLXSN-Ax1的转化体产生的重组Ax1; 含有重组载体pLXSN-Ax1的转化体的宿主细胞是小鼠RAW264.7巨噬细胞; 重组Gas6由含有重组载体pcDNA3.1（+）-GAS6的转化体产生; 含有重组载体pcDNA3.1（+） - GAS6的转化体的宿主细胞是小鼠OP9细胞系。
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公开(公告)号：KR100861117B1
公开(公告)日：2008-09-30
申请号：KR1020080013128
申请日：2008-02-13
Applicant: 전남대학교산학협력단
IPC: H01L31/04
CPC classification number: Y02E10/542 , H01L31/04
Abstract: A dye-sensitized solar cell using a copolymer binder including a hydroxy group and a carboxyl group and a manufacturing method thereof are provided to increase an open circuit voltage and short circuit current by using the copolymer. A relative electrode includes a light-transmitting material(10), a conductive light-transmitting layer(20), and a platinum layer(30). An optical electrode includes a copolymer binder comprising a hydroxy group and a carboxyl group, a mixture layer comprising a transition metal oxide, and a conductive light-transmitting layer. An electrolyte solution(50) is positioned between the relative electrode and the optical electrode. The copolymer binder comprising the hydroxy group and the carboxyl group is composed of a styrene-based monomer comprising a vinyl group, an acrylate-based monomer comprising the hydroxy group, and a methacrylic acid-based monomer including the carboxyl group.
Abstract translation: 提供使用包含羟基和羧基的共聚物粘合剂的染料敏化太阳能电池及其制造方法，以通过使用共聚物来增加开路电压和短路电流。 相对电极包括透光材料（10），导电透光层（20）和铂层（30）。 光电极包括包含羟基和羧基的共聚物粘合剂，包含过渡金属氧化物的混合物层和导电透光层。 电解质溶液（50）位于相对电极和光电极之间。 包含羟基和羧基的共聚物粘合剂由包含乙烯基的苯乙烯类单体，包含羟基的丙烯酸酯类单体和包含羧基的甲基丙烯酸类单体组成。
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公开(公告)号：KR101319141B1
公开(公告)日：2013-10-17
申请号：KR1020110139578
申请日：2011-12-21
Applicant: 전남대학교산학협력단
CPC classification number: Y02E10/542 , Y02P70/521
Abstract: 염료감응 태양전지용 천연염료 용액 제조방법 및 이를 이용한 천연염료 감응 태양전지 제조방법을 제공한다. 염료감응 태양전지용 천연염료 용액 제조방법은 천연염료 분말을 준비하는 단계; 및 상기 천연염료 분말, pH 조절제 및 용매를 혼합하여 천연염료 용액을 형성하는 단계를 포함하고, 상기 천연염료 용액은 식물 생장의 촉진 또는 억제를 위한 파장 선택성을 갖는 것을 특징으로 하는 염료감응 태양전지용 천연염료 용액 제조방법을 포함한다. 따라서, 흡수파장대가 다른 천연염료 용액을 조합하여 제조된 파장선택용 칵테일 용액을 적용하여 식물의 생장에 필요한 파장대에 적합한 천연염료 감응 태양전지를 다양하게 제조할 수 있다.
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