公开(公告)号：KR1020110124828A

公开(公告)日：2011-11-18

申请号：KR1020100044235

申请日：2010-05-12

Applicant: 전남대학교산학협력단

Inventor： 한호재 ,  김윤희 ,  류정민

IPC: C12N5/0735 ,  C13K1/00 ,  C07K14/78 ,  C12N5/02

Abstract: PURPOSE: A method for enhancing fibronectin using glucose of high concentration is provided to stimulate G1 progress and to proliferate embryonic stem cells. CONSTITUTION: A method for enhancing fibronectin synthesis is performed through angiotensin II and deformability growth factor-beta1(TGF-beta1) in case of treating mouse embryonic stem cells with 25mM or more of glucose. The glucose of high concentration activates angiotensin II type 1 receptor. The mouse embryonic stem cells are ES-E14TG2a or ES-R1. A medium for proliferating mouse embryonic stem cells contains 25mM or more of glucose.

Abstract translation: 目的：提供使用高浓度葡萄糖增强纤连蛋白的方法，以刺激G1进展并增殖胚胎干细胞。 构成：在用25mM或更多葡萄糖处理小鼠胚胎干细胞的情况下，通过血管紧张素II和变形性生长因子-β1（TGF-β1）进行增强纤连蛋白合成的方法。 高浓度葡萄糖激活血管紧张素II 1型受体。 小鼠胚胎干细胞是ES-E14TG2a或ES-R1。 用于增殖小鼠胚胎干细胞的培养基含有25mM或更多的葡萄糖。