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公开(公告)号：KR101402921B1
公开(公告)日：2014-06-02
申请号：KR1020130102400
申请日：2013-08-28
Applicant: 전남대학교산학협력단
Abstract: 본 발명은 비만 또는 제 2형 당뇨 치료를 위해 레스베라톨 유도체의 이용에 관한 것으로, 보다 상세하게는 피세아타놀(piceatannol), 피세이드(piceid) 또는 프테로스틸벤(pterostilbene)은 TREM-2 억제제로 작용할 수 있으며, 이에 의해 비만 또는 제 2형 당뇨의 예방 또는 치료에 이용할 수 있다. 또한 TREM-2(Triggering Receptor Expressed on Myeloid cells-2)를 억제함으로써 인슐린 대사와 관련된 유전자 및 지방세포 분화와 관련된 유전자의 발현조절을 제어할 수 있어 효과적으로 비만 또는 제 2형 당뇨를 치료하는데 유용하게 사용될 수 있는 장점이 있다.
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2.发明公开
公开(公告)号：KR1020150010326A
公开(公告)日：2015-01-28
申请号：KR1020130085180
申请日：2013-07-19
Applicant: 전남대학교산학협력단
IPC: A61K31/34 , A61K31/166 , A61K31/16 , A61P3/04
Abstract: The present invention relates to a composition for preventing or treating obesity and type 2 diabetes, or hepatic steatosis and, more specifically, to a composition for preventing or treating obesity and type 2 diabetes, or hepatic steatosis, containing derivatives including a main adipose differentiation promotion factor inhibitor or biaryl amide as an active ingredient. Additionally, by inhibiting a main adipose differentiation promotion factor and increasing Wnt10b, the composition according to the present invention can control differentiation of adipocytes, and increase insulin resistance and glucose resistance, thereby being effectively used for treating obesity and type 2 diabetes, or hepatic steatosis.
Abstract translation: 本发明涉及用于预防或治疗肥胖症和2型糖尿病或肝脂肪变性的组合物，更具体地，涉及用于预防或治疗肥胖症和2型糖尿病或肝脂肪变性的组合物，其包含主要脂肪分化促进的衍生物 因子抑制剂或联芳基酰胺作为活性成分。 另外，通过抑制主要的脂肪分化促进因子和增加Wnt10b，本发明的组合物可以控制脂肪细胞的分化，增加胰岛素抵抗和葡萄糖耐量，从而有效地用于治疗肥胖和2型糖尿病或肝脂肪变性 。
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公开(公告)号：KR1020130101493A
公开(公告)日：2013-09-13
申请号：KR1020130102400
申请日：2013-08-28
Applicant: 전남대학교산학협력단
Abstract: PURPOSE: A use of resverastrol derivatives is provided to suppress triggering receptor expressed on myeloid cells-2 (TREM-2) and to regulate the expression of genes related to insulin metabolism and adipocyte differentiation, thereby effectively treating obesity or type 2 diabetes. CONSTITUTION: A method for suppressing TREM-2 in animals exclusive of human comprises the step of administering a composition containing one or more selected among piceatannol, piceid, and pterostilbene as active ingredients to an individual. A method for treating obesity or type 2 diabetes caused by overexpression of TREM-2 gene in animals exclusive of human comprises the step of administering the composition to an individual. A method for increasing the expression of leptin, TNFalpha gene, and adiponectin gene in a TREM-2 transgenic mouse comprises the step of administering the composition to an individual.
Abstract translation: 目的：提供使用白藜芦醇衍生物以抑制在骨髓细胞-2（TREM-2）上表达的触发受体并调节与胰岛素代谢和脂肪细胞分化相关的基因的表达，从而有效治疗肥胖或2型糖尿病。 构成：不包括人类的动物中抑制TREM-2的方法包括向个体施用含有作为活性成分的作为活性成分的作为活性成分的皮质烷醇，皮质和蝶啶中的一种或多种的组合物的步骤。 在不包括人类的动物中，TREM-2基因过表达引起的肥胖症或2型糖尿病的治疗方法包括向个体施用组合物的步骤。 在TREM-2转基因小鼠中增加瘦素，TNFα基因和脂连蛋白基因表达的方法包括向个体施用组合物的步骤。
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