公开(公告)号：KR1020090090918A

公开(公告)日：2009-08-26

申请号：KR1020080016480

申请日：2008-02-22

Applicant: 전남대학교산학협력단

Inventor： 강형식 ,  김은미 ,  이은희 ,  박아름 ,  이화연 ,  이자운 ,  조영미

IPC: A61K38/16 ,  A61K48/00 ,  A61P35/00

CPC classification number: A61K38/005 ,  A61K48/00

Abstract: A composition for preventing and treating cervical cancer, which contains AxL receptor tyrosine kinase inhibitor is provided to regulate the expression of human papilloma virus (HPV) type 16 E6 gene and reduce the proliferation and metastatic property of cancer cell. A composition for preventing and treating cervical cancer comprises an inhibitor of Axl receptor tyrosine kinase as an active ingredient. A method for screening an agent for preventing and treating cervical cancer comprises: a step of adding a test compound to the Axl receptor tyrosine kinase; and a step of researching the influence of the test sample to the expression or activation of Axl and selecting a compound which suppresses the expression or activation of Axl.

Abstract translation: 提供含有AxL受体酪氨酸激酶抑制剂的宫颈癌预防和治疗组合物，用于调节人乳头状瘤病毒（HPV）16型E6基因的表达，降低癌细胞的增殖和转移性。 用于预防和治疗宫颈癌的组合物包含Ax1受体酪氨酸激酶的抑制剂作为活性成分。 用于筛选预防和治疗宫颈癌的药剂的方法包括：将测试化合物加入到Ax1受体酪氨酸激酶中的步骤; 研究测试样品对Axl的表达或活化的影响并选择抑制Ax1表达或激活的化合物的步骤。

公开(公告)号：KR1020120112973A

公开(公告)日：2012-10-12

申请号：KR1020110030606

申请日：2011-04-04

Applicant: 전남대학교산학협력단

Inventor： 강형식 ,  이자운 ,  윤철호 ,  김소영 ,  박민

IPC: A61K31/05 ,  A61K31/045 ,  A61K31/09 ,  A61P3/04

Abstract: PURPOSE: A composition containing TREM-2 inhibitors or resveratol is provided to control the expression of insulin metabolism-related genes and adipocyte differentiation-related genes and to effectively treat obesity or type 2 diabetes. CONSTITUTION: A composition for preventing or treating obesity contains TREM-2(triggering receptor expressed on myeloid cells-2) inhibitors as an active ingredient. The TREM-2 inhibitor is a compound of piceatannol, piceid, or pterostilbene. A composition for preventing or treating obesity or type 2 diabetes contains piceatannol, piceid, or pterostilbene compounds as an active ingredient. The composition for preventing or treating obesity or type 2 diabetes contains a resveratol derivative as an active ingredient.

Abstract translation: 目的：提供含有TREM-2抑制剂或白藜芦醇的组合物，以控制胰岛素代谢相关基因和脂肪细胞分化相关基因的表达，并有效治疗肥胖或2型糖尿病。 构成：用于预防或治疗肥胖症的组合物含有TREM-2（触发骨髓细胞-2表达受体）抑制剂作为活性成分。 TREM-2抑制剂是吡草胺，piceid或p芪烯的化合物。 用于预防或治疗肥胖症或2型糖尿病的组合物含有作为活性成分的皮沙替坦，皮质或p芪烯化合物。 用于预防或治疗肥胖症或2型糖尿病的组合物含有白藜芦醇衍生物作为活性成分。