-
公开(公告)号：KR100873168B1
公开(公告)日：2008-12-10
申请号：KR1020070022620
申请日：2007-03-07
Applicant: 전북대학교산학협력단
Abstract: 본 발명은
lon 유전자 및/또는
cpxR 유전자가 결실된 살모넬라 변이균주, 그 제조방법 및 상기 변이균주를 함유하는 약독화된 살모넬라 백신조성물에 관한 것이다.
본 발명에 따른 약독화된 살모넬라 생백신은 생산 및 보관이 용이하여 경제적이며, 가축에 투여 시, 안전하고 효율적으로 살모넬라 감염을 예방할 수 있다.
살모넬라, 생백신, 약독화, 변이균주-
2.发明公开
公开(公告)号：KR1020080082156A
公开(公告)日：2008-09-11
申请号：KR1020070022620
申请日：2007-03-07
Applicant: 전북대학교산학협력단
Abstract: An attenuated Salmonella live vaccine is provided to be easily and economically produced and stored and prevent Salmonella infection safely and efficiently when administered to a domestic animal. A method for preparing a Salmonella live vaccine comprises a step of deleting a lon or a cpxR gene from a chromosome DNA of a Salmonella strain such as Salmonella typhimurium, S. typhi, S. paratyphi, S. sendai, S. gallinarium and S. enteritidis. A vector includes a DNA where a DNA fragment linked to a 5'-terminal of the lon gene derived from the Salmonella strain and a DNA fragment linked to a 3'-terminal of the lon gene are bonded. An attenuated Salmonella vaccine composition comprises a Salmonella mutant where the lon gene and the cpxR gene are deleted from the chromosome DNA of the Salmonella and a pharmaceutically acceptable carrier.
Abstract translation: 提供减毒的沙门氏菌活疫苗，以便容易经济地生产和储存，并且当施用于家畜时安全有效地预防沙门氏菌感染。 一种制备沙门氏菌活疫苗的方法，包括从沙门氏菌菌株如鼠伤寒沙门氏菌，伤寒沙门氏菌，副伤寒沙门氏菌，沙门氏菌，沙门氏菌和沙门氏菌等染色体DNA中删除lon或cpxR基因的步骤。 肠炎。 载体包括与来自沙门氏菌属菌株的lon基因的5'末端连接的DNA片段和与lon基因的3'端连接的DNA片段连接的DNA。 减毒沙门氏菌疫苗组合物包含沙门氏菌突变体，其中lon基因和cpxR基因从沙门氏菌的染色体DNA和药学上可接受的载体中缺失。
-
Search Results
2
records
(took 0.019 seconds)
