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公开(公告)号：KR1020140046389A
公开(公告)日：2014-04-18
申请号：KR1020130120839
申请日：2013-10-10
Applicant: 전북대학교산학협력단
Abstract: The present invention relates to a pH-sensitive block copolymer containing cinnamaldehyde derivatives, and to a method for preparing same. The pH-sensitive block copolymer containing cinnamaldehyde derivatives according to the present invention forms micelles so as to enable the cinnamaldehyde derivatives to be retained in the body for a longer period of time. The micelles may be disintegrated, and the acetal bond to which the cinnamaldehyde derivatives are connected dissociates in the slightly acid pH of the cancer tissue, which thus generate and release cinnamaldehyde derivatives. The thus-released cinnamaldehyde derivatives may act specifically on cancer cells and thus may have less toxicity on normal cells. Therefore, the cinnamaldehyde derivatives have anti-cancer effects per se, and encapsulate an anti-cancer agent as a drug carrier and deliver the anti-cancer agent to the cancer cells.
Abstract translation: 本发明涉及含有肉桂醛衍生物的pH敏感性嵌段共聚物及其制备方法。 含有根据本发明的肉桂醛衍生物的pH敏感性嵌段共聚物形成胶束，以使肉桂醛衍生物能够在体内保持较长时间。 胶束可能被分解，并且肉桂醛衍生物连接的缩醛键在癌组织的微酸性pH中解离，从而产生和释放肉桂醛衍生物。 这样释放的肉桂醛衍生物可以特异性地对癌细胞起作用，因此可能对正常细胞具有较小的毒性。 因此，肉桂醛衍生物本身具有抗癌作用，并且包封抗癌剂作为药物载体并将抗癌剂递送至癌细胞。
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公开(公告)号：KR1020160092982A
公开(公告)日：2016-08-05
申请号：KR1020160098035
申请日：2016-08-01
Applicant: 전북대학교산학협력단
Abstract: 본발명은신남알데하이드유도체함유 pH 민감성블록공중합체및 이의제조방법에관한것이다. 본발명에따른신남알데하이드유도체함유 pH 민감성블록공중합체는마이셀을형성하여신남알데하이드유도체가체내에서보다오래지속되도록하고, 암조직의약산성 pH에서마이셀이붕괴되고신남알데하이드유도체가연결된아세탈결합이끊어져신남알데하이드유도체가생성및 방출되어암세포에특이적으로작용하여정상세포에미치는독성이적어그 자체만으로도항암효과가있으며, 약물전달체로서항암제를포접시켜암세포까지전달할수 있는효과가있다.
Abstract translation: 本发明涉及含有肉桂醛衍生物的PH敏感性嵌段共聚物及其制造方法。 包含根据本发明的肉桂醛衍生物的PH敏感性嵌段共聚物通过形成胶束而在体内继续肉桂醛衍生物，特别是通过使胶束在癌组织的微酸性PH中收缩而产生和排出肉桂醛衍生物而特异性地影响癌细胞 通过断开与肉桂醛衍生物连接的缩醛具有抗癌作用，因为PH敏感性嵌段共聚物对正常组织具有较小的毒性，并且具有能够通过连接将抗癌药物转移至癌组织的作用 抗癌药物与药物交付。 本发明提供一种包含肉桂醛的PH敏感性嵌段共聚物的高分子胶束。 本发明提供包括高分子胶束的药物递送。
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公开(公告)号：KR101797149B1
公开(公告)日：2017-12-12
申请号：KR1020160098035
申请日：2016-08-01
Applicant: 전북대학교산학협력단
CPC classification number: A61K9/1075
Abstract: 본발명은신남알데하이드유도체함유 pH 민감성블록공중합체및 이의제조방법에관한것이다. 본발명에따른신남알데하이드유도체함유 pH 민감성블록공중합체는마이셀을형성하여신남알데하이드유도체가체내에서보다오래지속되도록하고, 암조직의약산성 pH에서마이셀이붕괴되고신남알데하이드유도체가연결된아세탈결합이끊어져신남알데하이드유도체가생성및 방출되어암세포에특이적으로작용하여정상세포에미치는독성이적어그 자체만으로도항암효과가있으며, 약물전달체로서항암제를포접시켜암세포까지전달할수 있는효과가있다.
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