公开(公告)号：KR1020140042761A

公开(公告)日：2014-04-07

申请号：KR1020130116607

申请日：2013-09-30

Applicant: 전북대학교산학협력단

Inventor： 이동원 ,  홍동현 ,  피터강

IPC: C08G8/02 ,  C08G83/00 ,  A61K47/48 ,  A61K47/30 ,  A61P35/00 ,  A61K49/04

CPC classification number: A61K31/765 ,  A61K9/14 ,  A61K49/0093 ,  C08G63/133 ,  C08G8/02 ,  A61K47/30 ,  A61K49/04 ,  C08G63/18 ,  C08G83/00

Abstract: The present invention relates to a vanillyl alcohol-containing copolyoxalate (PVAX) copolymer, a PVAX microparticle comprising the PVAX, a drug delivery system including the PVAX microparticle, an antioxidant or anti-inflammatory composition, a composition for preventing or treating ischemic disease, a composition for inhibiting the side effects of anticancer drugs, a contrast agent, and a composition for diagnosing ischemic disease. The PVAX microparticle according to the present invention can be used as a drug delivery system and an antioxidant or anti-inflammatory composition because the PVAX microparticle according to the present invention is non-toxic, has outstanding biocompatibility and are degraded under physiological conditions while releasing vanillyl alcohol, which has outstanding antioxidant, anti-inflammatory and anti-apoptotic effects. And the PVAX microparticle according to the present invention can be used as a composition for inhibiting the side effects of anticancer drugs because the PVAX microparticle according to the present invention inhibits the side effects of anticancer drugs such as hepatic or cardiac abnormalities. Also, the PVAX microparticle according to the present invention can be used as a contrast agent or a composition for diagnosing ischemic disease because the PVAX microparticle according to the present invention specifically detects hydrogen peroxide in vivo.

Abstract translation: 本发明涉及含香草醇的共聚草酸酯（PVAX）共聚物，包含PVAX的PVAX微粒，包含PVAX微粒的药物递送系统，抗氧化剂或抗炎组合物，用于预防或治疗缺血性疾病的组合物 用于抑制抗癌药物的副作用的组合物，造影剂和用于诊断缺血性疾病的组合物。 根据本发明的PVAX微粒可以用作药物递送系统和抗氧化剂或抗炎组合物，因为根据本发明的PVAX微粒是无毒的，具有优异的生物相容性，并且在生理条件下降解同时释放香兰素 酒精，具有优异的抗氧化，抗炎和抗凋亡作用。 本发明的PVAX微粒可以用作抑制抗癌药物的副作用的组合物，因为本发明的PVAX微粒抑制抗癌药物如肝脏或心脏异常的副作用。 此外，根据本发明的PVAX微粒可以用作造影剂或用于诊断缺血性疾病的组合物，因为根据本发明的PVAX微粒在体内特异性检测过氧化氢。

公开(公告)号：KR101523231B1

公开(公告)日：2015-05-28

申请号：KR1020130116607

申请日：2013-09-30

Applicant: 전북대학교산학협력단

Inventor： 이동원 ,  홍동현 ,  피터강

IPC: C08G8/02 ,  C08G83/00 ,  A61K47/48 ,  A61K47/30 ,  A61P35/00 ,  A61K49/04

CPC classification number: A61K31/765 ,  A61K9/14 ,  A61K49/0093 ,  C08G63/133

Abstract: 본발명은 PVAX (vanillyl alcohol-containing copolyoxalate) 공중합체, 상기 PVAX 공중합체를포함하는 PVAX 미립구, 상기 PVAX 미립구를포함하는약물전달체, 항산화또는항염증용조성물, 허혈성질환의예방또는치료용조성물, 항암제부작용억제용조성물, 조영제및 허혈성질환의진단용조성물에관한것이다. 본발명에따른 PVAX 미립구는독성이없으며, 우수한생체적합성을가지고, 생리적조건에서분해되면서바닐릴알코올을방출함으로써뛰어난항산화, 항염증및 항세포사멸효과를가지고있어, 약물전달체및 항산화또는항염증용조성물로유용하게이용될수 있으며, 항암제투여로유도되는심장또는간 이상등의부작용을억제하는효과를가지고있어, 항암제부작용억제용조성물로이용될수 있다. 또한, 본발명에따른 PVAX 미립구는생체내에서과산화수소를특이적으로검출하는기능을가지고있어, 조영제또는허혈성질환의진단용조성물로유용하게이용될수 있다.

公开(公告)号：KR101273437B1

公开(公告)日：2013-06-11

申请号：KR1020110044279

申请日：2011-05-11

Applicant: 전북대학교산학협력단

Inventor： 이동원 ,  박현진 ,  김세호 ,  성경렬 ,  피터강

IPC: C08G63/18 ,  B82B3/00 ,  A61K9/32 ,  A61P35/00

CPC classification number: C08G63/19 ,  A61K47/59 ,  B82Y5/00

Abstract: 본 발명은 HPOX(HBA-incorporatred copolyoxalate) 화합물과 그 제조 방법, 상기 화합물을 유효성분으로 함유하는 염증성 질환(inflammatory disease)의 예방 또는 치료용 약학적 조성물과 항산화제(antioxidant agent)와 약물전달체(drug delivery vector), 및 상기 화합물에 형광물질(fluorescent material)이 포접(inclusion)된 영상조영제(imaging contrast agent)에 관한 것이다. 본 발명의 따른 HPOX 나노 입자는 표적 특이적 방식으로 체내 과산화수소와 NO의 농도를 효과적으로 감소시킴으로써 부작용이 없이 항염증 및 항산화 효과를 나타내며, 표적 특이적 작용 효과로 인하여 약물전달체 및 영상조영제로서 활용할 수도 있다.

公开(公告)号：KR1020110124168A

公开(公告)日：2011-11-16

申请号：KR1020110044279

申请日：2011-05-11

Applicant: 전북대학교산학협력단

Inventor： 이동원 ,  박현진 ,  김세호 ,  성경렬 ,  피터강

IPC: C08G63/18 ,  B82B3/00 ,  A61K9/32 ,  A61P35/00

CPC classification number: C08G63/19 ,  A61K47/59 ,  B82Y5/00

Abstract: PURPOSE: An HPOX(HBA-incorporatred copolyoxalate) compound is provided to ensure anti-inflammation and antioxidant effects by effectively reducing the concentration of NO and internal hydrogen peroxides through a target specific method. CONSTITUTION: An HPOX(HBA-incorporatred copolyoxalate) compound includes oxalyl chloride in which at least one monomer of 4-hydroxybenzly alcohol and vanillyl alcohol is integrated to a polymer skeleton. Nanoparticles are produced by performing polycondensation of oxalate, 1,4-cyclohexanedimethanol, and one or more monomers selected from the group consisting of 4-hydroxybenzyl alcohol and vanillyl alcohol.

Abstract translation: 目的：提供一种通过目标特异性方法有效降低NO和内部过氧化氢浓度来确保抗炎和抗氧化作用的HPOX（HBA-掺入的共聚草酸酯）化合物。 构成：HPOX（HBA-共聚共聚草酸酯）化合物包括草酰氯，其中至少一种4-羟基苯甲醇和香草醇单体与聚合物骨架结合。 通过进行草酸盐，1,4-环己烷二甲醇和一种或多种选自4-羟基苄醇和香草醇的单体的缩聚来制备纳米颗粒。