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1.发明公开시프로플록사신이 담지된 폴리락타이드글리콜라이드공중합체의 서방출 및 생분해성 나노입자 및 그 제조방법 有权具有扩展性能的聚（DL-柠檬酸 - 碳酸甘油酯）包封CIPROFLOXACIN HC的生物降解纳米颗粒及其制备方法
公开(公告)号：KR1020080039645A
公开(公告)日：2008-05-07
申请号：KR1020060107212
申请日：2006-11-01
CPC classification number: A61K9/5153 , A61K9/5089 , A61K9/5192
Abstract: A sustained release and bio-degradable nano-particle of a poly(DL-lactide-co-glycolide) copolymer is provided to release ciprofloxacin HCl gradually through controlling of physicochemical characteristics and drug release characteristics by encapsulating the ciprofloxacin into polylactide glycolide. A sustained release and bio-degradable nano-particle of a poly(DL-lactide-co-glycolide) copolymer is characterized in that it has a particle size of 100-500 nanometers and the poly(DL-lactide-co-glycolide) copolymer encapsulates ciprofloxacin HCl. A method for preparing the nano-particle comprises the steps of: (a) dissolving polylactideglycolide in dichloromethane to have a concentration of 2-6 weight/volume%; (b) dissolving ciprofloxacin in distilled water to have a concentration of 1-2 weight/volume%; (c) after mixing the solution obtained from the step(a) with the solution obtained from the step(b) in a weight ratio of 8-10:1, treating the mixture with an ultrasonic homogenizer with an output of 30-40 watts for 1-3 minutes per 10 ml to prepare a water in oil emulsion; and (d) after putting the W/O emulsion in an aqueous solution of polyvinyl alcohol having a concentration of 1.0 weight/volume%, treating the solution with a high-pressure homogenizer under a pressure of 600-800 bar with one minute cycle per 100 ml for 5-7 cycles to prepare a W/O/W emulsion. Further, a 4.5 to 5.0 wt.% of ciprofloxacin HCl is comprised in a 100 wt.% of nano-particle, and the ciprofloxacin HCl is emitted from the nano-particle for 10 days or more.
Abstract translation: 提供聚（DL-丙交酯 - 共 - 乙交酯）共聚物的持续释放和生物降解纳米颗粒，通过将环丙沙星包封在聚丙交酯乙交酯中，通过控制理化特性和药物释放特性逐渐释放环丙沙星HCl。 聚（DL-丙交酯 - 共 - 乙交酯）共聚物的持续释放和生物可降解纳米颗粒的特征在于其具有100-500纳米的粒度和聚（DL-丙交酯 - 共 - 乙交酯）共聚物 封装盐酸环丙沙星。 制备纳米颗粒的方法包括以下步骤：（a）将聚丙交酯乙二醇酸溶解在二氯甲烷中以具有2-6重量/体积％的浓度; （b）将环丙沙星溶解于蒸馏水中至浓度为1-2重量/体积％; （c）将由步骤（a）获得的溶液与步骤（b）获得的溶液以8-10:1的重量比混合后，用输出为30-40瓦的超声波均化器处理该混合物 每10ml处理1-3分钟，制备油包水乳液; 和（d）在将W / O乳液放入浓度为1.0重量/体积％的聚乙烯醇的水溶液中之后，在600-800巴的压力下用高压均化器处理该溶液，每1分钟循环 100毫升5-7个循环以制备W / O / W乳液。 此外，在100重量％的纳米颗粒中包含4.5-5.0重量％的环丙沙星HCl，并且从纳米颗粒中排出环丙沙星HCl 10天或更长时间。
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公开(公告)号：KR1020070072301A
公开(公告)日：2007-07-04
申请号：KR1020060022820
申请日：2006-03-10
CPC classification number: A61K8/736 , A61K8/11 , A61K8/671 , A61K2800/522 , A61K2800/84 , A61Q19/00
Abstract: Provided are a retinol encapsulated water-soluble chitosan nano-particle which is able to secure the stability and water-solubility of retinol, and a method for preparing the retinol encapsulated water-soluble chitosan nano-particle. The retinol encapsulated water-soluble chitosan nano-particle is characterized in that it has low molecular weight of 1,000-50,000Da and a particle size of 50-150 nanometers. The method comprises the steps of: (a) preparing a low molecular weight water-soluble chitosan solution; (b) preparing a retinol solution; (c) mixing the retinol solution with the chitosan solution and agitating it; and (c) freeze-drying the mixture solution.
Abstract translation: 提供了能够确保视黄醇的稳定性和水溶性的视黄醇包封的水溶性壳聚糖纳米粒子，以及制备视黄醇包封的水溶性壳聚糖纳米粒子的方法。 视黄醇包封的水溶性壳聚糖纳米颗粒的特征在于其具有1,000-50,000Da的低分子量和50-150纳米的粒度。 该方法包括以下步骤：（a）制备低分子量水溶性壳聚糖溶液; （b）制备视黄醇溶液; （c）将视黄醇溶液与壳聚糖溶液混合并搅拌; 和（c）冷冻干燥混合物溶液。
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公开(公告)号：KR100735740B1
公开(公告)日：2007-07-06
申请号：KR1020050072114
申请日：2005-08-08
CPC classification number: C07K14/79
Abstract: 본 발명은 트랜스페린 수용체 영상제제 및 그 제조 방법에 관한 것으로, 보다 상세하게는 방사성핵종으로 표지된 HYNIC-키토산-트랜스페린 배합체를 함유하는 트랜스페린 수용체 영상제제 및 그 제조 방법에 대한 것으로서, 본 발명에 따른 트랜스페린 수용체 영상제제는 세포독성이 없을 뿐만 아니라 표지효율이 높아 빠른 시간 안에 트랜스페린 수용체를 표적하여 감염부위의 영상을 얻을 수 있으므로 생체의 염증 및 종양과 같은 병리적 상태를 조기에 진단 및 치료하는 조영제로 유용하게 이용될 수 있다.
핵의학 영상, 감마 영상, 조영제, 키토산, 트랜스페린, HYNIC, 테크네튬-
公开(公告)号：KR1020070013747A
公开(公告)日：2007-01-31
申请号：KR1020050068329
申请日：2005-07-27
IPC: C08B37/08
CPC classification number: C08B37/003 , A21D2/18 , A21D2/34 , A23G9/32 , A23L2/02 , A23L2/52 , A23L5/00 , A23L7/00 , A23L23/00 , A23L25/30 , A23L27/63 , A23L29/20 , A23L29/275 , A23L29/30 , A23L33/10 , A23L33/125 , A23V2002/00 , A23V2250/511 , B01D61/145
Abstract: Provided are a water-soluble chitosan oligosaccharide having high purity which has an average molecular weight of 1000-11000 Da and an average molecular weight distribution of 1-1-1.5, a method for preparing the same, and a composition comprising the same. The water-soluble chitosan oligosaccharide has an average molecular weight of 1000-11000 Da, and an average molecular weight distribution of 1-1.5. The method for preparing the water-soluble chitosan oligosaccharide comprises the steps of (i) classifying/separating a water-soluble chitosan oligosaccharide according to molecular weight by using ultrafiltration membrane, (ii) removing and lyophilizing impurities of water-soluble chitosan oligosaccharide solution obtained respectively, (iii) precipitating the lyophilized water-soluble chitosan oligosaccharide in organic solvent to obtain a water-soluble chitosan oligosaccharide of powder type, and (iv) drying the water-soluble chitosan oligosaccharide of powder type under vacuum.
Abstract translation: 本发明提供平均分子量为1000〜1000Da，平均分子量分布为1-1〜1.5的纯度高的水溶性壳聚糖寡糖及其制备方法及其组合物。 水溶性壳聚糖寡糖的平均分子量为1000〜1000Da，平均分子量分布为1-1.5。 制备水溶性壳聚糖寡糖的方法包括以下步骤：（i）通过使用超滤膜将水溶性壳聚糖寡糖按分子量进行分类/分离，（ii）除去并冻干获得的水溶性壳聚糖寡糖溶液的杂质 （iii）将冻干的水溶性壳聚糖寡糖在有机溶剂中沉淀，得到粉末型的水溶性壳聚糖寡糖，（iv）在真空下干燥粉末状的水溶性壳聚糖寡糖。
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公开(公告)号：KR1020030026191A
公开(公告)日：2003-03-31
申请号：KR1020010070052
申请日：2001-11-12
IPC: C08B37/08
Abstract: PURPOSE: A method for preparing a water-soluble free amine chitosan is provided, to obtain a pure water-soluble free amine chitosan with a molecular weight of 1,000-100,000 Dalton. CONSTITUTION: The method comprises the steps of treating a solution of salts of an organic acid or an inorganic acid of chitosan oligosaccharide with a trialkylamine; adding an organic solvent to the solution to recover the chitosan oligosaccharide by removing an organic acid or an inorganic acid in the form of a trialkylamine salt; and treating the chitosan oligosaccharide solution with an inorganic acid and purifying the solution with an activated carbon/ion exchange resin column. Preferably the organic acid is selected from the group consisting of lactic acid, acetic acid, propionic acid, formic acid, ascorbic acid and tartaric acid; and the inorganic acid is selected from the group consisting of HCl, HNO3 and H2SO4.
Abstract translation: 目的：提供一种制备水溶性游离胺壳聚糖的方法，以获得分子量为1,000-100,000道尔顿的纯水溶性游离胺壳聚糖。 方法：该方法包括用三烷基胺处理壳聚糖寡糖的有机酸或无机酸的溶液的步骤; 向溶液中加入有机溶剂以通过除去三烷基胺盐形式的有机酸或无机酸来回收壳聚糖寡糖; 用无机酸处理壳聚糖寡糖溶液，用活性炭/离子交换树脂柱纯化溶液。 优选有机酸选自乳酸，乙酸，丙酸，甲酸，抗坏血酸和酒石酸; 无机酸选自HCl，HNO 3和H 2 SO 4。
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Patent Agency Ranking
公开(公告)号：KR1020090099939A
公开(公告)日：2009-09-23
申请号：KR1020080025247
申请日：2008-03-19
Applicant: 정특래
CPC classification number: A23L27/50 , A23L11/20 , A23L33/00 , A23V2002/00 , A23V2200/308 , A23V2200/324 , A23V2250/28
Abstract: PURPOSE: A method for preparing a soy sauce or soybean paste using chitooligosaccharides is provided to use a chitooligosaccharide solution with molecular weight of 13,000 or less as water. CONSTITUTION: A method for preparing a soy sauce or soybean paste using chitooligosaccharides comprises a step of using a chitooligosaccharide solution as water in a producing process of soy sauces or soybean paste. The average molecular weight of the chitooligosaccharide is 13,000 or less. A method for preparing the chitooligosaccharide solution comprises the following steps of: dissolving chitosan in hydrochloric acid to obtain a chitosan-hydrochloride solution; adding a chitosanase to the chitosan-hydrochloride solution to form a chitosanoligosaccharide; filtering the chitosanoligosaccharide-containing solution to remove unreacted materials and refining with a ultrafiltration membrane; and adding caustic soda to the refined solution to neutralize it and desalting and concentrating the neutralized solution.
Abstract translation: 目的：提供使用壳低聚糖制备酱油或大豆酱的方法，使用分子量为13,000以下的壳寡糖溶液作为水。 构成：使用壳低聚糖制备酱油或大豆酱的方法包括在大豆酱或大豆酱的生产过程中使用壳寡糖溶液作为水的步骤。 壳低聚糖的平均分子量为13,000以下。 一种制备壳寡糖溶液的方法，包括以下步骤：将壳聚糖溶解在盐酸中，得到壳聚糖盐酸盐溶液; 向壳聚糖 - 盐酸溶液中加入壳聚糖酶形成壳寡糖; 过滤含有脱乙酰壳多糖的溶液以除去未反应的物质并用超滤膜进行精制; 并向精制溶液中加入苛性钠以中和它，并对中和的溶液进行脱盐和浓缩。
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公开(公告)号：KR100780014B1
公开(公告)日：2007-11-28
申请号：KR1020050068329
申请日：2005-07-27
IPC: C08B37/08
CPC classification number: C08B37/003 , A21D2/18 , A21D2/34 , A23G9/32 , A23L2/02 , A23L2/52 , A23L5/00 , A23L7/00 , A23L23/00 , A23L25/30 , A23L27/63 , A23L29/20 , A23L29/275 , A23L29/30 , A23L33/10 , A23L33/125 , A23V2002/00 , A23V2250/511
Abstract: 본 발명은 고순도 수용성 키토산 올리고당, 이를 포함하는 조성물 및 그의 제조방법에 관한 것으로, 보다 상세하게는 고순도 수용성 키토산 올리고당은 평균 분자량이 1000 ~ 11000 Da, 평균 분자량 분포가 1 ~ 1.5, 고유 점도가 0.020 ~ 0.250 g/㎝·sec, 탈아세틸화도가 90 ~ 95%, 수분 함량이 1.0 ~ 3.0%, 무기질 함량이 0 ~ 1%이며, 한외여과막을 이용하여 키토산 올리고당으로부터 분자량별로 분급, 분리하여 고순도 수용성 키토산 올리고당을 제조하는 방법에 관한 것이다. 본 발명의 고순도 수용성 키토산 올리고당은 매우 좁은 분자량 분포와 높은 순도를 갖고 있으며, 세포독성이 거의 나타나지 않으므로 의약용 뿐만 아니라 건강식품용의 다양한 분야에서 유용하게 사용될 수 있다.
키토산 올리고당-
公开(公告)号：KR100762954B1
公开(公告)日：2007-10-04
申请号：KR1020060008233
申请日：2006-01-26
CPC classification number: A61K31/722 , A61K9/0019 , A61K9/1075 , A61K9/5161 , A61K47/36
Abstract: 본 발명은 항암제가 봉입된, 소수성 담즙산이 결합된 친수성 키토산 올리고당 나노입자 및 그 제조방법에 관한 것으로, 상기 소수성 담즙산이 결합된 친수성 키토산 올리고당 나노입자는 수계에서 자가응집형태를 형성하며 자가응집형태의 내부에 항암제를 포함할 수 있다. 본 발명의 항암제가 봉입된, 소수성 담즙산이 결합된 친수성 키토산 올리고당 나노입자는 약물의 봉입률이 매우 높으며, 암세포에 대한 세포독성이 높을 뿐만 아니라, 생체 내에서 약물을 장기간 지속적으로 방출할 수 있어 지속적인 항암효과를 나타내므로 암에 대한 항암화학요법에 유용하게 사용될 수 있다.
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公开(公告)号：KR1020060006562A
公开(公告)日：2006-01-19
申请号：KR1020040055649
申请日：2004-07-16
CPC classification number: C08L5/08 , A61K9/5161 , A61K9/5192 , A61K47/36 , C08J3/12 , C08J3/14 , C08J2305/08
Abstract: 본 발명은 항암제의 전달체용 수용성 키토산 나노입자(water soluble chitosan nanoparticle; WSC-NP) 및 그 제조방법에 관한 것으로, 항암물질 전달체의 기본 구성물로 수용성 키토산을 사용하여, 수용성 키토산 그 자체의 아민기가 가지는 강한 양전하(+)로 인해 음전하(-)를 띤 DNA와 복합체를 형성함으로써 유전자 전달체(gene carrier)로서도 매우 우수하고, 또한 반응성이 높은 유리 아민기의 위치에 다른 기능성기(functional group)를 도입함으로써 목적하는 부위를 표적할 수 있는 기능을 부여함으로써 항암제의 효율적인 약물 전달체용 수용성 키토산 나노입자 및 그 제조방법을 제공한다. 따라서, 본 발명에 따른 항암제의 전달체용 수용성 키토산 나노입자는 수용성 키토산의 반응성이 높은 유리 아민기의 위치에 친수성 및 소수성기를 각각 도입함으로써 항암제인 파클리탁셀를 용이하게 봉입할 수 있고, 이렇게 제조된 수용성 키토산 나노파클리탁셀은 동결건조 후 증류수에서의 재분산 능력이 매우 뛰어나고, 기존의 다른 항암제 전달체에 비해 종양 세포에 더 많이 축적될 수 있어 탁월한 항암효과를 나타낸다.
수용성 키토산, 나노입자, 항암제, 파클리탁셀.-
公开(公告)号：KR1020070078196A
公开(公告)日：2007-07-31
申请号：KR1020060008233
申请日：2006-01-26
CPC classification number: A61K31/722 , A61K9/0019 , A61K9/1075 , A61K9/5161 , A61K47/36
Abstract: Provided is an anticancer agent-encapsulated and a hydrophobic bile acid-conjugated hydrophilic chitosan oligosaccharide nanoparticle which shows high encapsulation rate of anti-cancer agent, high cytotoxicity against cancer cells and continuous anti-cancer effect by releasing the anti-cancer agent for a long period of time in vivo so as to be usefully used for chemotherapy. The hydrophilic chitosan oligosaccharide nanoparticle encapsulates an anti-cancer agent and is conjugated with a hydrophobic bile acid which is selected from the group consisting of lithocholic acid, deoxycholic acid, cholic acid, chenodeoxycholic acid, 7-oxo-lithocholic acid and 5beta-cholanic acid. The method comprises the steps of: (a) preparing a bile acid solution by dissolving a hydrophobic bile acid together with an activating agent in a solvent with agitation to activate the bile acid; (b) dissolving a hydrophilic chitosan oligosaccharide in a solvent to prepare a chitosan oligosaccharide solution; (c) reacting the chitosan oligosaccharide solution with the activated bile acid solution to prepare a bile acid-conjugated chitosan oligosaccharide solution; (d) dialyzing and filtering the bile acid-conjugated chitosan oligosaccharide solution to prepare an auto-coagulative type bile acid-conjugated chitosan oligosaccharide nanoparticle solution; and (e) adding an anti-cancer solution to the auto-coagulative type of bile acid-conjugated chitosan oligosaccharide nanoparticle solution so as to encapsulate the anti-cancer agent into the nanoparticle.
Abstract translation: 本发明提供了一种抗癌剂包封和疏水性胆汁酸共轭的亲水性壳聚糖寡糖纳米粒子，其显示出抗癌剂的高包封率，对癌细胞的高细胞毒性和持续的抗癌作用，通过将抗癌剂长时间释放 一段时间在体内，以便有用地用于化疗。 亲水性壳聚糖寡糖纳米粒子包封抗癌剂，并与选自石胆酸，脱氧胆酸，胆酸，鹅脱氧胆酸，7-氧代 - 石胆酸和5β-胆酸的疏水性胆汁酸共轭 。 该方法包括以下步骤：（a）通过在搅拌下将疏水性胆汁酸与活化剂一起溶解在溶剂中以活化胆汁酸来制备胆汁酸溶液; （b）将亲水性壳聚糖寡糖溶解在溶剂中以制备壳聚糖寡糖溶液; （c）使壳聚糖寡糖溶液与活化胆汁酸溶液反应，制备胆汁酸结合的壳聚糖寡糖溶液; （d）透析和过滤胆汁酸结合的壳聚糖寡糖溶液，制备自凝凝型胆汁酸结合的壳聚糖寡糖纳米颗粒溶液; 和（e）将抗癌溶液加入到自凝凝型胆汁酸结合的壳聚糖寡糖纳米颗粒溶液中，以将抗癌剂包封在纳米颗粒中。
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