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公开(公告)号：KR101282847B1
公开(公告)日：2013-07-05
申请号：KR1020110074618
申请日：2011-07-27
Applicant: 조선대학교산학협력단
IPC: A61K31/4709 , A61K31/47 , A61K47/48 , A61K47/38
Abstract: 본 발명은 실로스타졸과 폴리메타크릴레이트 공중합체와의 고체분산체로서, 수-난용성 약물인 실로스타졸의 용해도를 현저하게 증가시킨 고체분산체; 및 이를 함유한 약학 조성물을 제공한다. 상기 약학 조성물은 생리학적 수성 매질 중에서 초기부터 신속하게 실로스타졸을 방출시킴으로써 높은 생체이용률을 달성할 수 있으며, 따라서 복용량을 감소시킬 수 있으므로 높은 안전성을 기대할 수 있다.
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公开(公告)号：KR1020130013157A
公开(公告)日：2013-02-06
申请号：KR1020110074618
申请日：2011-07-27
Applicant: 조선대학교산학협력단
IPC: A61K31/4709 , A61K31/47 , A61K47/48 , A61K47/38
CPC classification number: A61K31/4709 , A61K9/0053 , A61K9/10 , A61K47/14
Abstract: PURPOSE: A solid dispersion of cilostazol and polymethacrylate copolymers, and a pharmaceutical composition containing the same are provided to quickly release cilostazol and to reduce the dosage. CONSTITUTION: A solid dispersion with polymethacylate copolymers contains cilostazol. The copolymer is a copolymer of methacrylic acid and methyl methacrylate, a copolymer of methacrylic acid and ethyl acrylate, an ammonio methacrylate, or a copolymer of butyl methacrylate, (2-dimethyl aminoethyl)methacrylate, and methyl methacrylate. The solid dispersion additionally contains one or more polymers selected from a group consisting of hydroxypropylmethyl cellulose, polyvinyl pyrrolidone, crospovidone, or a copolymer of vinylpyrrolidone and vinyl acetate. An oral pharmaceutical composition contains the solid dispersion and a pharmaceutically acceptable additive. [Reference numerals] (AA) Elution rate(%); (BB) Comparative embodiment 9; (CC) Comparative embodiment 10; (DD) Pletaal Tab.; (EE) Embodiment 7; (FF) Time(h)
Abstract translation: 目的：提供西洛他唑和聚甲基丙烯酸酯共聚物的固体分散体和含有它们的药物组合物以快速释放西洛他唑并减少剂量。 构成：含有聚甲基丙烯酸酯共聚物的固体分散体含有西洛他唑。 共聚物是甲基丙烯酸和甲基丙烯酸甲酯的共聚物，甲基丙烯酸和丙烯酸乙酯的共聚物，甲基丙烯酸铵，或甲基丙烯酸丁酯，（2-二甲基氨基乙基）甲基丙烯酸酯和甲基丙烯酸甲酯的共聚物。 固体分散体还含有一种或多种选自羟丙基甲基纤维素，聚乙烯吡咯烷酮，交聚维酮或乙烯基吡咯烷酮和乙酸乙烯酯的共聚物的聚合物。 口服药物组合物含有固体分散体和药学上可接受的添加剂。 （附图标记）（AA）洗脱率（％）; （BB）比较实施例9; （CC）比较实施例10; （DD）Pletaal Tab （EE）实施例7; （FF）时间（h）
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