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公开(公告)号:KR1020050097218A
公开(公告)日:2005-10-07
申请号:KR1020040022331
申请日:2004-03-31
Applicant: 주식회사 디지탈바이오테크놀러지 , 재단법인서울대학교산학협력재단
IPC: G01N15/14
CPC classification number: G01N15/1459 , G01N15/1434 , G01N15/1436 , G01N15/1484 , G01N2015/0073 , G01N2015/008 , G01N21/6404 , G01N2021/5957
Abstract: Disclosed is a micro particle analyzing device illuminating light to fluid including micro particles, reading the lights emitted from the micro particles at a signal processing reading section and thus analyzing the micro particles. The device comprises a light source section emitting light which will be illuminated to the fluid; a lens regulating an amount and a focal distance of the light emitted from the light source; and a concave mirror condensing light emitted from the micro particle to reflect it to the reading section wherein the concave mirror is formed with a hole so that the light of the light source section having passed through the lens can pass through the concave mirror. When analyzing the micro particles using the analyzing device according to the invention, the amounts of lights emitted from the micro particles according to up-and-down positions of the micro particles are not different.
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公开(公告)号:KR100670590B1
公开(公告)日:2007-01-17
申请号:KR1020050093500
申请日:2005-10-05
Applicant: 주식회사 디지탈바이오테크놀러지 , 재단법인서울대학교산학협력재단
CPC classification number: G01N15/1404 , B01L3/502761 , B01L3/502776 , B01L2200/0652 , B01L2200/0694 , B01L2200/146 , B01L2400/049 , B01L2400/084 , G01N2015/1413
Abstract: A microchip with an expanded channel and a fine particle-analyzing apparatus using the same are provided to increase the working amount of the sample processing by placing the focusing channel even if the speed of the sample and the sheath flows is increased. A microchip comprises a sample channel where the sample is flowed; a sheath flow channel where the sheath flow is flowed; a focusing channel where the sample particles sheath and focused with the sample and the sheath flow are flowed; and an expansion channel for expanding the point circumference of the focusing channel where the sample is analyzed. The focused sample particles keep the focusing status, lower the speed, and improve the detection effect of the sample particles when the focused sample particles pass through the expansion channel.
Abstract translation: 提供具有扩展通道的微芯片和使用该微芯片的微粒分析装置,即使样品和护套流动的速度增加,通过放置聚焦通道来增加样品处理的工作量。 微芯片包括样品流动的样品通道; 护套流动的护套流动通道; 样品颗粒鞘并与样品和护套流动聚焦的聚焦通道; 以及用于扩大分析样品的聚焦通道的点圆周的扩展通道。 当聚焦的样品颗粒通过扩展通道时,聚焦的样品颗粒保持聚焦状态,降低速度,并提高样品颗粒的检测效果。
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公开(公告)号:KR100600923B1
公开(公告)日:2006-07-13
申请号:KR1020040022331
申请日:2004-03-31
Applicant: 주식회사 디지탈바이오테크놀러지 , 재단법인서울대학교산학협력재단
IPC: G01N15/14
CPC classification number: G01N15/1459 , G01N15/1434 , G01N15/1436 , G01N15/1484 , G01N2015/0073 , G01N2015/008
Abstract: 본 발명은 미세입자를 포함하는 유체에 빛을 조사하고, 상기 미세입자로부터 발하는 빛을 신호처리 판독부가 판독하여 미세입자를 분석하는 장치에 있어서, 상기 유체에 조사할 빛을 발하는 광원부; 상기 광원부로부터 발한 빛의 양과 초점거리를 조절하는, 수치구경이 작은 렌즈; 및 상기 미세입자가 발하는 빛을 집광하여 판독부로 반사시키기 위한, 수치구경이 큰 오목거울을 포함하되, 상기 오목거울에는, 상기 렌즈를 통과한 광원부의 빛이 상기 오목거울을 통과할 수 있도록 홀이 형성되어 있는 미세입자 분석 장치에 관한 것이다.
본 발명에 따른 분석 장치를 사용하여 미세입자를 분석하는 경우, 상기 미세입자가 흐르는 미세채널 내에서의 미세입자의 상하 위치에 따라서 미세입자로부터 방출되는 빛의 양이 달라지지 않는다. 따라서, 상기 미세입자를 정확하게 분석할 수 있다.-
公开(公告)号:KR1020110075448A
公开(公告)日:2011-07-06
申请号:KR1020090131901
申请日:2009-12-28
Applicant: 주식회사 나노엔텍 , 주식회사 디지탈바이오테크놀러지
Abstract: PURPOSE: A method for manufacturing a microfluidic device and the microfluidic device manufactured by the same are provided to completely seal the sample charging space of the device and precisely combining an upper board and a lower board. CONSTITUTION: A first fine channel(30) is formed and receives a bonding organic solvent. A second fine channel(32) is formed between a sample charging space and the first fine channel in order to function as a buffer space for the organic solvent. An upper board(1) is overlapped with a lower board(2). The organic solvent is introduced into the first fine channel to bond the upper board and the lower board.
Abstract translation: 目的:提供一种用于制造微流体装置的方法和由其制造的微流体装置,以完全密封装置的样品充电空间并精确地组合上板和下板。 构成:形成第一细孔(30)并接收粘结有机溶剂。 在样品充电空间和第一精细通道之间形成第二细通道(32),以用作有机溶剂的缓冲空间。 上板(1)与下板(2)重叠。 将有机溶剂引入第一精细通道以粘合上板和下板。
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公开(公告)号:KR1020080054043A
公开(公告)日:2008-06-17
申请号:KR1020060126104
申请日:2006-12-12
Applicant: 주식회사 디지탈바이오테크놀러지
CPC classification number: G01N1/38 , G01N15/1056 , G01N15/12 , G01N2015/1062 , G01N2015/1087
Abstract: A sample pre-treatment device and a sample analysis apparatus using the same are provided to maintain a constant volume of a mixing chamber having a pre-treatment liquid even if samples are inputted into the mixing chamber. A sample pre-treatment device includes a sample mixing chamber(10), guide members(20,21), a sample storage member(30), and a sample transfer member(40). The sample mixing chamber is equipped with a piston(12) on one end and has an internal space. The guide members are formed on the wall of the sample mixing chamber. The sample storage member is formed on the wall of the sample mixing chamber, connected to one end of one of the guide members, and has an internal space to receive a sample. The sample transfer member has a thickness to pass through the inside of the guide member. A space is formed in the middle of the sample transfer member to contain only a desired amount of sample.
Abstract translation: 提供样品预处理装置和使用其的样品分析装置,以便即使将样品输入到混合室中,也保持具有预处理液体的混合室的恒定体积。 样品预处理装置包括样品混合室(10),引导构件(20,21),样品储存构件(30)和样品转移构件(40)。 样品混合室在一端装有活塞(12)并具有内部空间。 引导构件形成在样品混合室的壁上。 样品存储构件形成在样品混合室的壁上,连接到一个引导构件的一端,并且具有用于接收样品的内部空间。 样品转印构件具有穿过引导构件内部的厚度。 在样品转印构件的中间形成空间,以仅含有所需量的样品。
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公开(公告)号:KR100519672B1
公开(公告)日:2005-10-11
申请号:KR1020030094615
申请日:2003-12-22
Applicant: 주식회사 디지탈바이오테크놀러지
IPC: G01N35/00
CPC classification number: B01L3/502746 , B01L2200/0636 , B01L2200/0647 , G01N15/1404 , G01N15/1463 , G01N2015/0073 , G01N2015/1413
Abstract: 본 발명은 미세입자가 일렬로 흐르게 하기 위하여, 상기 미세입자를 포함하는 유체를 포커싱하여 흐르게 하는 포커싱 채널 장치에 있어서, 경사면을 구비하는 좌측벽면 및 우측벽면에 의하여 형성되는 노즐부를 포함하되, 상기 노즐부의 폭방향 단면은 상기 노즐부의 입구로부터 상기 노즐부의 출구로 갈수록 단면적이 감소하며, 상기 채널 장치의 길이방향의 단면 형상은 상기 채널 장치의 길이방향의 중심선을 기준으로 좌우 비대칭인 포커싱 채널 장치에 관한 것이다.
본 발명에 따른 장치를 사용하여 유체를 포커싱하는 경우, 상기 유체 내의 입자들이 서로 결합하지 않고, 하나씩 차례로 채널을 통과하게 되므로, 채널이 막히거나 두 개 이상의 입자가 결합하여 이동하는 현상이 발생하지 않는다. 따라서, 본 발명에 따른 장치를 사용하여 입자를 관찰함으로써, 정확한 실험 결과를 얻을 수 있다.-
公开(公告)号:KR1020050010709A
公开(公告)日:2005-01-28
申请号:KR1020040053031
申请日:2004-07-08
Applicant: 주식회사 디지탈바이오테크놀러지
IPC: G01N15/02
CPC classification number: G01N15/0227 , G01N2015/0065 , G01N2021/5957
Abstract: PURPOSE: An apparatus for counting micro particles is provided to quickly and exactly measure the number of particles by using a micro counting part. CONSTITUTION: An apparatus for counting micro particles includes a sample chip(20), a light source(10), an image photographing unit, a micro particle counting part(60), and a chip movement part(27). The sample chip(20) nests samples having a predetermined volume including micro particles on a reading part. The light source(10) irradiates light on a predetermined area of the sample chip(20). The image photographing unit photographs the sample on the predetermined area. The micro particle counting part counts particles in a predetermined area of the sample chip(20) based on the image photographed by means of the image photographing unit. The sample chip(10) is moved in such a manner that an area next to the predetermined area photographed by the image photographing unit comes to an irradiation area.
Abstract translation: 目的:提供一种用于计数微粒的装置,通过使用微计数部分快速准确地测量颗粒数。 构成:用于计数微粒子的装置包括样品芯片(20),光源(10),图像拍摄单元,微粒计数部分(60)和芯片移动部分(27)。 样品芯片(20)在读取部分上嵌套包含微粒子的预定体积的样品。 光源(10)将光照射在样品芯片(20)的预定区域上。 图像拍摄单元在预定区域拍摄样品。 微粒计数部基于通过图像拍摄单元拍摄的图像来计数样品芯片(20)的预定区域中的颗粒。 样品芯片(10)以使得由图像拍摄单元拍摄的预定区域旁边的区域到达照射区域的方式移动。
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公开(公告)号:KR1020040012009A
公开(公告)日:2004-02-11
申请号:KR1020020045354
申请日:2002-07-31
Applicant: 주식회사 디지탈바이오테크놀러지
IPC: G01N37/00
Abstract: PURPOSE: Provided is a method for fabricating a micro chip for mixing, assaying, separating or measuring samples associated with medical and various industrial applications, the micro chip having one or more micro channel regions, by a simplified molding process at low cost, thereby easily fabricating a plurality of micro chips each having an accurately controlled dimension using a mold in a reducible manner, and reducing the fabrication cost and time. CONSTITUTION: The method for fabricating a micro chip(200) having a body(205) made of a plastic material, and first and second micro channel regions(210,215) formed in the body(205) to communicate with each other, the method comprises: forming a first micro channel forming layer on a plate; forming the first micro channel region(210) using the first micro channel forming layer; forming a second micro channel forming layer on the plate having the first micro channel region(210); forming the second micro channel region(215) using the second micro channel forming layer; and completing the micro chip(200) having the first and second channel regions(210,215) using the plate as a mold.
Abstract translation: 目的:提供一种用于混合,测定,分离或测量与医疗和各种工业应用相关的样品的微芯片的方法,该微芯片具有一个或多个微通道区域,通过简化的成型工艺以低成本,因此容易 使用模具以可还原的方式制造各自具有精确控制尺寸的多个微芯片,并且降低制造成本和时间。 构成:用于制造具有由塑料材料制成的主体(205)的微芯片(200)的方法,以及形成在主体(205)中以彼此连通的第一和第二微通道区域(210,215),该方法包括 :在板上形成第一微通道形成层; 使用所述第一微通道形成层形成所述第一微通道区域(210); 在具有第一微通道区域(210)的板上形成第二微通道形成层; 使用所述第二微通道形成层形成所述第二微通道区域(215); 以及使用该板作为模具来完成具有第一和第二通道区域(210,215)的微芯片(200)。
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公开(公告)号:KR100396960B1
公开(公告)日:2003-09-02
申请号:KR1020000065954
申请日:2000-11-07
IPC: A61B1/005
Abstract: PURPOSE: A controlling apparatus of a travel direction adjustment operating device of an endoscope is provided to increase a bending angle of an operating device of the endoscope and give a function for adjusting the travel direction to the operating device. CONSTITUTION: A controlling apparatus of a travel direction adjustment operating device of an endoscope comprises coordinate reading units(60,62), a first and a second non-inverting amplifiers(28,30), a first to a third inverting amplifiers(32,34,36), a first to a seventh summing inverters(38-50), a trigonal wave generator(52), and a first to a third comparators(54,56,58). The non-inverting amplifiers(28,30) multiply an X value from the reading unit(60) with two multipliers, respectively. The inverting amplifiers(32,34,36) invert the multiplied values from the non-inverting amplifiers(28,30) and a Y value from the reading unit(62). The first to the fourth summing inverters(38-44) add the Y value and the outputs of the inverting amplifiers(32,36) and the non-inverting amplifier(28), and output the inverted sums, respectively. The fifth to the seventh summing inverters(46-50) add the outputs of the non-inverting amplifier(30), the first to the fourth summing inverters(38-44), and the inverting amplifier(34), and output the inverted sums, respectively. The comparators(54-58) compare the outputs of the fifth to the seventh summing inverters(46-50) with the output of the trigonal wave generator(52), respectively.
Abstract translation: 目的:提供一种内窥镜的行进方向调整操作装置的控制装置,其增加内窥镜的操作装置的弯曲角度,并具有调整对操作装置的行进方向的功能。 本发明公开了一种内窥镜的行进方向调节操作装置的控制装置,包括坐标读取单元(60,62),第一和第二非反相放大器(28,30),第一至第三反相放大器(32,32) 34,36),第一至第七求和倒相器(38-50),三角波发生器(52)以及第一至第三比较器(54,56,58)。 非反相放大器(28,30)分别将来自读单元(60)的X值乘以两个乘法器。 反相放大器(32,34,36)反相来自非反相放大器(28,30)的相乘值和来自读单元(62)的Y值。 第一到第四加法反相器(38-44)分别将Y值和反相放大器(32,36)和非反相放大器(28)的输出相加,并分别输出反相和。 第五至第七求和反相器(46-50)将非反相放大器(30),第一至第四求和反相器(38-44)和反相放大器(34)的输出相加,并将反相 总和,分别。 比较器(54-58)分别将第五到第七加法反相器(46-50)的输出与三角波发生器(52)的输出进行比较。
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10.
公开(公告)号:KR1020020035693A
公开(公告)日:2002-05-15
申请号:KR1020000065951
申请日:2000-11-07
IPC: A61B1/012
Abstract: PURPOSE: A method for manufacturing a catheter exterior wire using 3-dimensional thin film forming process and a catheter having the same are provided to form electricity wire on the surface of the catheter and implement automatically, accurately and fast. CONSTITUTION: For manufacturing a catheter exterior conducting wire, a conducting wire pattern is formed to be coupled to a surface of a catheter(30). The catheter(30) has an inserting tunnel(32) and a ground hole(34). The conducting wire pattern is used to supply power to 3 shape memory alloy wires and a ground wire included in a micro actuator mounted at the end of the catheter(30). Four copper wires of the pattern travel spirally from the end of the catheter(30) to a front end and are bent parallel to each other toward the three wire and the ground of the actuator. The ground hole(34) and a ground tunnel connected to the ground hole(34) are formed at the end of the conducting wire pattern. When conductive polysolder is injected into the ground hole(34), the patterned wire is electrically coupled to a micro pin in the ground hole(34) to drive the actuator.
Abstract translation: 目的:提供一种使用三维薄膜形成工艺制造导管外线的方法和具有该方法的导管,以在导管表面上形成电线并自动,准确且快速地实现。 构成:为了制造导管外导线,形成导线图形以联接到导管(30)的表面。 导管(30)具有插入通道(32)和接地孔(34)。 导线图案用于向安装在导管(30)端部的微型致动器中的3个形状记忆合金线和包含在内的微型致动器中的接地线供电。 图案的四条铜线从导管(30)的端部螺旋地行进到前端,并且彼此平行地朝向三线和致动器的地面弯曲。 接地孔(34)和连接到接地孔(34)的接地通道形成在导线图案的末端。 当将导电聚合物注入到接地孔(34)中时,图案化的导线电耦合到接地孔(34)中的微销以驱动致动器。
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