公开(公告)号：KR100670590B1

公开(公告)日：2007-01-17

申请号：KR1020050093500

申请日：2005-10-05

Applicant: 주식회사 디지탈바이오테크놀러지 ,  재단법인서울대학교산학협력재단

Inventor： 장준근 ,  방현우 ,  윤호영 ,  조근창 ,  정찬일

IPC: G01N15/02 ,  G01N15/00

CPC classification number: G01N15/1404 ,  B01L3/502761 ,  B01L3/502776 ,  B01L2200/0652 ,  B01L2200/0694 ,  B01L2200/146 ,  B01L2400/049 ,  B01L2400/084 ,  G01N2015/1413

Abstract: A microchip with an expanded channel and a fine particle-analyzing apparatus using the same are provided to increase the working amount of the sample processing by placing the focusing channel even if the speed of the sample and the sheath flows is increased. A microchip comprises a sample channel where the sample is flowed; a sheath flow channel where the sheath flow is flowed; a focusing channel where the sample particles sheath and focused with the sample and the sheath flow are flowed; and an expansion channel for expanding the point circumference of the focusing channel where the sample is analyzed. The focused sample particles keep the focusing status, lower the speed, and improve the detection effect of the sample particles when the focused sample particles pass through the expansion channel.

Abstract translation: 提供具有扩展通道的微芯片和使用该微芯片的微粒分析装置，即使样品和护套流动的速度增加，通过放置聚焦通道来增加样品处理的工作量。 微芯片包括样品流动的样品通道; 护套流动的护套流动通道; 样品颗粒鞘并与样品和护套流动聚焦的聚焦通道; 以及用于扩大分析样品的聚焦通道的点圆周的扩展通道。 当聚焦的样品颗粒通过扩展通道时，聚焦的样品颗粒保持聚焦状态，降低速度，并提高样品颗粒的检测效果。

公开(公告)号：KR1020020085903A

公开(公告)日：2002-11-18

申请号：KR1020010025374

申请日：2001-05-10

Applicant: 주식회사 디지탈바이오테크놀러지 ,  대한민국(관리부서 서울대학교(정밀기계설계공동연구소))

Inventor： 장준근 ,  정찬일 ,  정석 ,  이용구 ,  방현우

IPC: C12Q1/68

Abstract: PURPOSE: A micro mixing channel device is provided, thereby simultaneously and simply obtaining at least two mixed materials having the accurate mixing ratio. CONSTITUTION: The micro mixing channel device comprises the parts of: a supplying unit; a first panel element; a second panel element which contacts with the first panel element; a plurality of inlet units which connect the supplying unit to the first panel element; at least one outlet unit which is installed on the side of the first panel element; and a channel circuit which is positioned between the first panel element and the second panel element and connects the inlet unit to the outlet unit, wherein the channel circuit contains at least one channel unit; and the channel circuit is connected to the outlet unit to supply the outlet unit with the mixed materials having accurate mixing ratio; and the supplying unit supplies a constant volume of fluid per unit time.

Abstract translation: 目的：提供微混合通道装置，从而同时且简单地获得具有精确混合比的至少两种混合材料。 构成：微混合通道装置包括：供料单元; 第一面板元件; 与所述第一屏元件接触的第二屏元件; 多个入口单元，其将所述供应单元连接到所述第一面板元件; 至少一个安装在所述第一屏元件一侧的出口单元; 以及通道电路，其位于所述第一屏元件和所述第二屏元件之间，并且将所述入口单元连接到所述出口单元，其中所述通道电路包含至少一个通道单元; 并且通道电路连接到出口单元以向出口单元提供具有精确混合比的混合材料; 并且供应单元每单位时间提供恒定体积的流体。

公开(公告)号：KR1020050009612A

公开(公告)日：2005-01-25

申请号：KR1020030049406

申请日：2003-07-18

Applicant: 주식회사 디지탈바이오테크놀러지

Inventor： 장준근 ,  정석 ,  정찬일 ,  방현우 ,  조한상

IPC: G01N15/14

CPC classification number: B82Y15/00 ,  G01N15/1456 ,  G01N33/49 ,  G01N2015/1486 ,  G02B21/34 ,  Y10T156/1039

Abstract: PURPOSE: An apparatus for counting cells and a method for manufacturing the same are provided to give convenience to a user by easily filling a filling room with test samples. CONSTITUTION: An apparatus for counting cells is used for counting particles. The apparatus for counting cells includes a lower substrate and an upper substrate(100). The lower substrate(200) has a particle lattice pattern for counting the number of the cell. The lower substrate(200) has a light transmitting characteristic. The upper substrate has a light transmitting characteristic. The upper substrate is stacked and installed on the lower substrate. The upper substrate includes a filling room and a sample inserting hole(120). The filling room is formed with a predetermined height from a bottom surface and has particles on the particle lattice pattern of the lower substrate(200).

Abstract translation: 目的：提供一种用于计数细胞的装置及其制造方法，以便通过容易地填充具有测试样本的填充室来为使用者提供便利。 构成：用于计数细胞的装置用于计数颗粒。 细胞计数装置包括下基板和上基板（100）。 下基板（200）具有用于对单元数进行计数的粒子格子图案。 下基板（200）具有透光特性。 上基板具有透光特性。 上基板堆叠并安装在下基板上。 上基板包括填充室和样品插入孔（120）。 填充室从底面形成有预定高度，并且在下基板（200）的颗粒格子图案上具有颗粒。

公开(公告)号：KR100442680B1

公开(公告)日：2004-08-02

申请号：KR1020010025374

申请日：2001-05-10

Applicant: 주식회사 디지탈바이오테크놀러지 ,  대한민국(관리부서 서울대학교(정밀기계설계공동연구소))

Inventor： 장준근 ,  정찬일 ,  정석 ,  이용구 ,  방현우

IPC: C12Q1/68

Abstract: PURPOSE: A micro mixing channel device is provided, thereby simultaneously and simply obtaining at least two mixed materials having the accurate mixing ratio. CONSTITUTION: The micro mixing channel device comprises the parts of: a supplying unit; a first panel element; a second panel element which contacts with the first panel element; a plurality of inlet units which connect the supplying unit to the first panel element; at least one outlet unit which is installed on the side of the first panel element; and a channel circuit which is positioned between the first panel element and the second panel element and connects the inlet unit to the outlet unit, wherein the channel circuit contains at least one channel unit; and the channel circuit is connected to the outlet unit to supply the outlet unit with the mixed materials having accurate mixing ratio; and the supplying unit supplies a constant volume of fluid per unit time.

Abstract translation: 目的：提供一种微混合通道装置，由此同时且简单地获得具有精确混合比率的至少两种混合材料。 构成：微混合通道装置包括以下部件：供应单元; 第一面板元件; 与第一面板元件接触的第二面板元件; 多个入口单元，其将供应单元连接到第一面板元件; 至少一个插座单元，其安装在第一面板元件的侧面上; 以及位于第一面板元件和第二面板元件之间并将入口单元连接到出口单元的通道回路，其中通道回路包含至少一个通道单元; 并且通道电路连接到出口单元以向出口单元提供具有精确混合比率的混合材料; 并且供应单元每单位时间供应恒定体积的流体。

公开(公告)号：KR1020020085904A

公开(公告)日：2002-11-18

申请号：KR1020010025375

申请日：2001-05-10

Applicant: 주식회사 디지탈바이오테크놀러지 ,  대한민국(관리부서 서울대학교(정밀기계설계공동연구소))

Inventor： 이용구 ,  장준근 ,  방현우

IPC: C12Q1/68

Abstract: PURPOSE: A method for producing a mixing channel device and a method for fixing a tube on a panel are provided, therefore the tube can be correctly and stably fixed on a molding plate without damage of the molding plate and other structures. CONSTITUTION: The method for producing the mixing channel device comprises the steps of: (a) preparing the molding plate having embossed shape corresponding to a channel circuit; (b) attaching a magnet in the rear side of the molding plate; (c) positioning a magnetic structure in one side of the tube on the molding plate; (d) molding a first channel element on the molding plate; and (e) separating the magnetic and the molding plate from the first channel element. The method for fixing the tube on the panel comprises the steps of: (a) attaching the magnet in the rear side of the molding plate; (b) positioning the magnetic structure in one side of the tube on the molding plate; (c) molding the panel on the molding plate; and (d) separating the magnetic and the molding plate from the panel.

Abstract translation: 目的：提供一种制造混合通道装置的方法和将管固定在面板上的方法，因此可以将管正确稳定地固定在模制板上而不损坏模制板和其它结构。 构成：制造混合通道装置的方法包括以下步骤：（a）制备具有对应于通道电路的压花形状的模制板; （b）在模板的后侧安装磁体; （c）将磁性结构定位在成型板上的管的一侧; （d）在模制板上模制第一通道元件; 和（e）将磁性和模制板与第一通道元件分离。 用于将管固定在面板上的方法包括以下步骤：（a）将磁体安装在模制板的后侧; （b）将磁性结构定位在成型板上的管的一侧; （c）在模板上模制面板; 和（d）将磁性和模制板与面板分离。

公开(公告)号：KR100430383B1

公开(公告)日：2004-05-04

申请号：KR1020010025375

申请日：2001-05-10

Applicant: 주식회사 디지탈바이오테크놀러지 ,  대한민국(관리부서 서울대학교(정밀기계설계공동연구소))

Inventor： 이용구 ,  장준근 ,  방현우

IPC: C12Q1/68

Abstract: PURPOSE: A method for producing a mixing channel device and a method for fixing a tube on a panel are provided, therefore the tube can be correctly and stably fixed on a molding plate without damage of the molding plate and other structures. CONSTITUTION: The method for producing the mixing channel device comprises the steps of: (a) preparing the molding plate having embossed shape corresponding to a channel circuit; (b) attaching a magnet in the rear side of the molding plate; (c) positioning a magnetic structure in one side of the tube on the molding plate; (d) molding a first channel element on the molding plate; and (e) separating the magnetic and the molding plate from the first channel element. The method for fixing the tube on the panel comprises the steps of: (a) attaching the magnet in the rear side of the molding plate; (b) positioning the magnetic structure in one side of the tube on the molding plate; (c) molding the panel on the molding plate; and (d) separating the magnetic and the molding plate from the panel.

Abstract translation: 目的：提供一种制造混合通道装置的方法以及将管固定在面板上的方法，因此，管可以正确且稳定地固定在模制板上而不会损坏模制板和其他结构。 本发明的混合通道装置的制造方法包括以下步骤：（a）准备与通道回路对应的具有压花形状的成型板; （b）将磁体安装在模制板的后侧; （c）将磁性结构放置在成型板上的管的一侧; （d）在模制板上模制第一通道元件; 和（e）将磁性模板和模制板从第一通道元件分离。 用于将管固定在面板上的方法包括以下步骤：（a）将磁体附接在模制板的后侧; （b）将所述磁结构定位在所述模制板上的所述管的一侧中; （c）在模制板上模制面板; 和（d）将磁性模板和模板从面板上分开。

公开(公告)号：KR1020030032811A

公开(公告)日：2003-04-26

申请号：KR1020020030430

申请日：2002-05-30

Applicant: 장준근 ,  방현우 ,  주식회사 디지탈바이오테크놀러지

Inventor： 장준근 ,  방현우 ,  정찬일 ,  조한상 ,  이용구

IPC: B81B7/00

CPC classification number: B81B1/002 ,  B81B1/006 ,  B81B2201/05 ,  B81C1/00071

Abstract: PURPOSE: A minute channel device for mixing fluid using a minute channel and a mixing method thereof are provided to achieve plural mixtures having a predetermined density ratio by utilizing resistance of fluid, which is varied depending on a size of the minute channel. CONSTITUTION: A minute channel device includes a first storing region(120), a second storing region, a first minute channel structure(140) and a second minute channel structure(160). The first minute channel structure(140) includes a first inlet(150), into which fluid(A) is introduced, a first inlet channel(143) connected to the first inlet(150), a first branch area(180) formed at one end of the first inlet channel(143), first and second branch channels(146,149) branched from the first branch area(180), a first outlet(153) and a second outlet(156). The second minute channel structure(160) includes a second inlet(170), into which fluid(B) is introduced, a second inlet channel(163) connected to the second inlet(170), a second branch area(190) formed at one end of the second inlet channel(163), third and fourth branch channels(166,169) branched from the second branch area(190), a third outlet(173) and a fourth outlet(176).

Abstract translation: 目的：提供用于使用微通道混合流体的微通道装置及其混合方法，以通过利用流体的阻力来实现具有预定密度比的多种混合物，其根据微通道的尺寸而变化。 构成：微通道装置包括第一存储区域（120），第二存储区域，第一微通道结构（140）和第二微通道结构（160）。 第一分钟通道结构（140）包括第一入口（150），流体（A）被引入到该第一入口中，连接到第一入口（150）的第一入口通道（143） 第一入口通道（143）的一端，从第一分支区域（180）分支的第一和第二分支通道（146,149），第一出口（153）和第二出口（156）。 第二分钟通道结构（160）包括第二入口（170），流体（B）被引入其中，第二入口通道（163）连接到第二入口（170），第二分支区域（190）形成在 第二入口通道（163）的一端，从第二分支区域（190）分支的第三和第四分支通道（166,169），第三出口（173）和第四出口（176）。

公开(公告)号：KR100573621B1

公开(公告)日：2006-04-25

申请号：KR1020030049406

申请日：2003-07-18

Applicant: 주식회사 디지탈바이오테크놀러지

Inventor： 장준근 ,  정석 ,  정찬일 ,  방현우 ,  조한상

IPC: G01N15/14

CPC classification number: B82Y15/00 ,  G01N15/1456 ,  G01N33/49 ,  G01N2015/1486 ,  G02B21/34 ,  Y10T156/1039

Abstract: 본 발명은 세포의 개체수를 계수하기 위한 장치로서, 더욱 구체적으로, 상면에 상기 세포를 계수하기 위한 미세격자패턴이 형성되어 있는 투광성 하부기판과, 상기 하부기판 상에 적층하여 설치되는 투광성의 상부기판을 포함하며, 상기 상부기판은, 그 저면으로부터 소정 높이로 형성되어 상기 하부기판의 미세격자패턴 상에 상기 세포를 포함하는 시료를 충전하기 위한 공간을 형성하는 충전실과, 상기 충전실에 연결된 시료용 투입구를 구비하는 것을 특징으로 하는 장치에 관한 것이다.
본 발명에 따른 장치는 상기 상부기판과 하부기판이 접합된 일체형이므로, 종래의 세포 계수용 장치에서와 같이 커버를 덮는 과정이 필요없다. 따라서, 상기 투입구에 시료를 떨어뜨려 상기 충전실에 상기 시료를 충전하는 것이 용이하므로, 종래 장치보다 훨씬 편리하게 사용할 수 있다. 또한, 세포 계수용 장치의 제조 비용이 크게 감소되므로, 1회용으로 편리하게 사용할 수 있다.

公开(公告)号：KR100473364B1

公开(公告)日：2005-03-08

申请号：KR1020020030430

申请日：2002-05-30

Applicant: 장준근 ,  방현우 ,  주식회사 디지탈바이오테크놀러지

Inventor： 장준근 ,  방현우 ,  정찬일 ,  조한상 ,  이용구

IPC: B81B7/00

Abstract: 미세 채널을 흐르는 유체에 대한 저항을 이용하여 2 이상의 유체를 일련의 비로 혼합하여 제공하는 미세 채널 장치 및 그 방법이 개시된다. 본 발명에 따른 미세 채널 장치는 몸체, 2 이상의 유체가 혼합되는 복수개의 저장 영역, 하나의 유입단ㆍ복수개의 배출단 및 미세 채널 회로를 구비하여 각각의 유체를 저장 영역에 배출하는 복수개의 미세 채널 구조를 구비하며, 상기 미세 채널 회로를 흐르는 유체에 대한 저항을 조절하여 각 배출단에서 배출되는 유체의 양을 달리하여 소정의 비율에 따라 2이상의 유체를 혼합한다. 유체의 흐름을 제어하기 위하여 채널에 전압을 인가하는 등의 별도의 에너지를 이용하는 것이 아니라 채널의 형상, 치수 및 배치를 조정하기 때문에 장치의 제작이 저렴 및 간단하고 장치의 조작을 용이하게 할 수 있다.

公开(公告)号：KR1020040012010A

公开(公告)日：2004-02-11

申请号：KR1020020045355

申请日：2002-07-31

Applicant: 주식회사 디지탈바이오테크놀러지

Inventor： 장준근 ,  정석 ,  방현우 ,  신기천 ,  조한상

IPC: G01N33/49

Abstract: PURPOSE: Provided is a cell counter and a method for manufacturing the same by using semiconductor processing technique and molding technique, thereby manufacturing the cell counter having a accurately controlled size. CONSTITUTION: In a cell counter for blood cells or bacteria cells, it is characterized by comprising a main body manufactured by transparent plastic, at least one projection providing a measurement space to the main body, and at least one decision portion which is formed on the space provided by the projection and consists of a decision part with latticed patterns and a compartment part. The main body and projection are composed of poly dimethyl siloxane. It further comprises a glass cover.

Abstract translation: 目的：提供一种电池计数器及其制造方法，通过使用半导体加工技术和成型技术，从而制造具有精确控制尺寸的电池计数器。 构成：在血细胞或细菌细胞的细胞计数器中，其特征在于包括由透明塑料制成的主体，至少一个向主体提供测量空间的突起，以及形成在主体上的至少一个判定部 由投影提供的空间，由具有网格图案和隔间部分的决定部分组成。 主体和突起由聚二甲基硅氧烷组成。 它还包括玻璃盖。