公开(公告)号：KR1020070009934A

公开(公告)日：2007-01-19

申请号：KR1020050064571

申请日：2005-07-16

Applicant: 주식회사 씨티씨바이오 ,  신풍제약주식회사

Inventor： 권도우 ,  유세근 ,  이봉상 ,  전홍렬 ,  박수준 ,  김병용 ,  노정렬

IPC: A61K9/22 ,  A61K31/445

CPC classification number: A61K9/2054 ,  A61K9/2027 ,  A61K9/2846 ,  A61K9/2866 ,  A61K31/4525

Abstract: A sustained-release tablet comprising paroxetine hydrochloride is provided to show low initial discharge rate of the paroxetine hydrochloride and be able to discharge the paroxetine hydrochloride at almost zero-order speed for about 12 hours. The sustained-release tablet comprises paroxetine hydrochloride, a high viscous polymer such as a high viscous hydroxypropylmethylcellulose, a mixture polymer consisting of polyvinyl acetate and povidone in a weight ratio of 8:2 and ethyl cellulose, a low viscous hydroxypropylmethylcellulose, and a pharmaceutically acceptable excipient such as a mixture of mannitol and lactose.

Abstract translation: 提供了包含帕罗西汀盐酸盐的缓释片剂，以显示出帕罗西汀盐酸盐的初始排出率低，并且能够以几乎零级速度将帕罗西汀盐酸盐排出约12小时。 缓释片剂包括盐酸帕罗西汀，高粘度聚合物如高粘度羟丙基甲基纤维素，由聚乙酸乙烯酯和聚维酮组成的混合物，其重量比为8:2，乙基纤维素，低粘度羟丙基甲基纤维素和药学上可接受的 赋形剂如甘露糖醇和乳糖的混合物。