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Patent Agency Ranking
公开(公告)号：KR101210812B1
公开(公告)日：2012-12-10
申请号：KR1020100071427
申请日：2010-07-23
Applicant: 충남대학교산학협력단
Abstract: 본발명은편평태선진단용마커로서의 Brn2의용도에관한것이다. 보다구체적으로, 본발명은 Brn2 유전자를이용한편평태선진단용마커, 이를이용한편평태선진단용조성물, 키트, 마이크로어레이및 편평태선의진단방법에관한것이고, 또한 Brn2 유전자또는단백질의발현을억제하여편평태선을예방또는치료할수 있는물질을스크리닝하는방법및 상기물질을포함하는편평태선의예방또는치료용조성물에관한것이다. 본발명에따른 Brn2 유전자는정상적인조직또는세포에비해편평태선의조직또는세포에서발현양이증가되는것으로확인됨에따라 Brn2 유전자를편평태선진단용마커로사용할경우편평태선을조기에신속하고정확하게진단및 예측할수 있는효과가있으므로편평태선의발병을진단하는진단용시약또는치료제의타겟으로이용할수 있으며, 나아가편평태선의발병메카니즘을연구할수 있는기초자료를제공하는데유용하게사용할수 있다.
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公开(公告)号：KR101210718B1
公开(公告)日：2012-12-10
申请号：KR1020100071422
申请日：2010-07-23
Applicant: 충남대학교산학협력단
Abstract: 본발명은이식편대숙주병진단용마커로서의 Brn2의용도에관한것으로서, 보다구체적으로는 Brn2 유전자를이용한이식편대숙주병진단용마커, 이를이용한이식편대숙주병진단용조성물, 키트, 마이크로어레이및 이식편대숙주병의진단방법에관한것이고, 또한 Brn2 유전자또는단백질의발현을억제하여이식편대숙주병을예방또는치료할수 있는물질을스크리닝하는방법및 상기물질을포함하는이식편대숙주병의예방또는치료용조성물에관한것이다. 본발명에따른 Brn2 유전자는정상적인조직또는세포에비해이식편대숙주병의조직또는세포에서발현양이증가되는것으로확인됨에따라 Brn2 유전자를이식편대숙주병진단용마커로사용할경우이식편대숙주병을조기에신속하고정확하게진단및 예측할수 있는효과가있으며, 나아가이식편대숙주병의치료제개발을위한표적으로활용할수 있는효과가있다.
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公开(公告)号：KR1020120072895A
公开(公告)日：2012-07-04
申请号：KR1020100134822
申请日：2010-12-24
Applicant: 충남대학교산학협력단
IPC: A61K38/16 , C12N15/867 , C12N15/861 , A61P17/00
CPC classification number: A61K38/179 , A61K48/005 , C12N15/861 , C12N15/867 , G01N2500/00
Abstract: PURPOSE: An Id1 protein for preventing or treating fibrosis is provided to relieve symptom due to collagen synthesis and to reduce collagen expression induced by TGF-beta 1/Smad 2,3. CONSTITUTION: A pharmaceutical composition for preventing or treating fibrosis contains Id1(inhibitory of DNA binding 1) protein or a polynucleotide encoding the protein as an active ingredient. The protein is Id1-v2 having an amino acid sequence of sequence number 1. A polynucleotide encoding the protein has a base of sequence number 2. An expression vector contains the polynucleotide. The expression vector is a retrovirus vector or adenovirus vector. A method for screening a candidate material for preventing or treating fibrosis comprises: a step of contacting a candidate material to Id1 protein or a recombinant cells expressing the protein; a step of measuring Id1 protein level and activation or gene expression level; and a step of determining the candidate material is the material for preventing or treating fibrosis in case of the expression level and activation is increased over a control group.
Abstract translation: 目的：提供用于预防或治疗纤维化的Id1蛋白，以减轻由于胶原合成引起的症状，并减少TGF-β1/ Smad 2,3诱导的胶原表达。 构成：用于预防或治疗纤维化的药物组合物含有Id1（抑制DNA结合1）蛋白质或编码该蛋白质的多核苷酸作为活性成分。 蛋白质是具有序列号1的氨基酸序列的Id1-v2。编码蛋白质的多核苷酸具有序列号2的碱基。表达载体含有多核苷酸。 表达载体是逆转录病毒载体或腺病毒载体。 用于筛选用于预防或治疗纤维化的候选材料的方法包括：使候选材料与Id1蛋白或表达蛋白质的重组细胞接触的步骤; 测量Id1蛋白水平和活化或基因表达水平的一个步骤; 并且确定候选材料的步骤是在表达水平和激活增加超过对照组的情况下用于预防或治疗纤维化的材料。
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公开(公告)号：KR1020120010005A
公开(公告)日：2012-02-02
申请号：KR1020100071427
申请日：2010-07-23
Applicant: 충남대학교산학협력단
CPC classification number: C12Q1/6883 , A61K48/00 , C12Q2600/158 , C12Q2600/178 , G01N33/5308
Abstract: PURPOSE: A marker for diagnosing lichen planus, Brn2, is provided to enhance expresison level of Brn2 gene in a tissue or cells with lichen planus. CONSTITUTION: A marker for diagnosing lichen planus contains Brn2 gene or protein. The Brn2 gene has a base sequence of sequence number 1. The Brn2 protein has an amino acid of sequence number 2. A composition for diagnosing lichen planus contains a material for measuring Brn2 gene or protein level. The materials are a primer or probe. A pharmaceutical composition for preventing or treating lichen planus contains an antisense having a compelmentery sequence with Brn2 sequence or siRNA oligonucleotide as an active ingredient.
Abstract translation: 目的：提供用于诊断扁平苔藓Brn2的标记物，以增强组织或扁平苔藓细胞中Brn2基因的表达水平。 构成：诊断扁平苔藓的标记物含有Brn2基因或蛋白质。 Brn2基因具有序列号1的碱基序列.Brn2蛋白具有序列号2的氨基酸。用于诊断扁平苔藓的组合物含有用于测量Brn2基因或蛋白质水平的材料。 材料是底漆或探针。 用于预防或治疗扁平苔藓的药物组合物含有具有Brn2序列或siRNA寡核苷酸作为活性成分的补体序列的反义。
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公开(公告)号：KR1020120010003A
公开(公告)日：2012-02-02
申请号：KR1020100071422
申请日：2010-07-23
Applicant: 충남대학교산학협력단
CPC classification number: C12Q1/6883 , A61K48/00 , C12Q2600/158 , C12Q2600/178 , G01N33/5308
Abstract: PURPOSE: A marker for diagnosing graft-versus-host disease, Brn2, is provided to quickly and accurately diagnose and predict graft-versus-host disease. CONSTITUTION: A marker for diagnosing graft-versus-host disease contains Brn2 gene or protein encoded from the gene. The Brn2 gene has a base sequence of sequence number 1. The Brn2 protein has an amino acid sequence of sequence number 2. A composition for diagnosing graft-versus-host disease contains a material for measuring Brn2 gene mRNA or protein level.
Abstract translation: 目的：用于诊断移植物抗宿主病的标记物Brn2用于快速准确地诊断和预测移植物抗宿主病。 构成：用于诊断移植物抗宿主病的标记物含有Brn2基因或从该基因编码的蛋白质。 Brn2基因具有序列号1的碱基序列.Brn2蛋白具有序列号2的氨基酸序列。用于诊断移植物抗宿主病的组合物含有用于测量Brn2基因mRNA或蛋白质水平的材料。
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