폴리뉴클레오티드를 표적 세포에 전달하기 위한 초분자 복합체
    2.
    发明公开
    폴리뉴클레오티드를 표적 세포에 전달하기 위한 초분자 복합체 失效
    用于将多核苷酸递送至目标细胞的分子复合物

    公开(公告)号:KR1020110074287A

    公开(公告)日:2011-06-30

    申请号:KR1020090131203

    申请日:2009-12-24

    CPC classification number: C07H15/26 C07H1/00

    Abstract: PURPOSE: A supramolecular complex for effectively delivering polynucleotides to target cells by forming a polyplex is provided. CONSTITUTION: A supramolecular complex for delivering polynucleotides to target cells contains oligoamine-linked carbohydrate and ligand-linked cucurbituril. The oligoamine is spermine, spermidine, putrescine, 1,6-diaminohexane, 1,5-diaminopentane, adamantane, metallocene, or mixture thereof. The ligand is galactose, mannose, glucose, N-acetylglucosamine, lactose, transferrine, citric acid, or mixture thereof.

    Abstract translation: 目的:提供通过形成聚合物将多核苷酸有效递送至靶细胞的超分子复合物。 构成:用于将多核苷酸递送至靶细胞的超分子复合物包含寡胺连接的碳水化合物和配体连接的葫芦素。 寡胺是精胺,亚精胺,腐胺,1,6-二氨基己烷,1,5-二氨基戊烷,金刚烷,茂金属或其混合物。 配体是半乳糖,甘露糖,葡萄糖,N-乙酰氨基葡萄糖,乳糖,转铁蛋白,柠檬酸或其混合物。

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