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公开(公告)号：WO2010120021A1
公开(公告)日：2010-10-21
申请号：PCT/KR2009/006032
申请日：2009-10-20
IPC: A61K47/34
CPC classification number: A61K9/4816 , A61K9/5146 , A61K31/337 , A61K31/506 , A61K31/704 , A61K41/0071 , A61K47/34 , A61K47/58 , A61N5/062 , Y10T428/2982
Abstract: 본 발명은 화학식 1로 표시되는 판상구조 단분자 화합물 및 화학식 2로 표시되는 유기 화합물이 공중합하여 형성된 직경 10 내지 2000 nm 크기의 고분자 캡슐을 포함하는 광역학 치료용 조성물을 제공한다:
Abstract translation: 本发明提供了一种用于光动力疗法的组合物，其包含通过由化学式1表示的平面单分子化合物与由化学式2表示的有机化合物共聚形成的尺寸在10和2,000nm之间的聚合物胶囊。
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2.发明公开
公开(公告)号：KR1020110076469A
公开(公告)日：2011-07-06
申请号：KR1020090133187
申请日：2009-12-29
Applicant: 포항공과대학교 산학협력단
IPC: A61K9/22 , A61K47/30 , A61K39/395 , A61P35/00
CPC classification number: A61K9/20 , A61K39/395 , A61K47/38 , B82Y5/00
Abstract: PURPOSE: A method for preparing a self-assembled drug and a cell delivery system is provided to easily synthesize a polymer composite and to prepare a drug and cell delivery system. CONSTITUTION: A method for preparing a self-assembled drug and a cell delivery system comprises a step of mixing: a compound of chemical formula I([B]m-[H]n); a drug, fluorescent substance, radioactive isotope, target oriented material, or imaging material which interacts with the compound of chemical formula I; and a functional group which interacts with the compound of chemical formula I in a solvent. The solvent is water, saline solution, buffer solution, or ethanol. The self-assembled delivery system is a hydrogel.
Abstract translation: 目的：提供一种制备自组装药物和细胞递送系统的方法，以容易地合成聚合物复合物并制备药物和细胞递送系统。 构成：制备自组装药物和细胞递送系统的方法包括混合化学式I（[B] m- [H] n）的化合物; 与化学式I化合物相互作用的药物，荧光物质，放射性同位素，靶向材料或成像材料; 以及在溶剂中与化学式I的化合物相互作用的官能团。 溶剂为水，盐水溶液，缓冲溶液或乙醇。 自组装输送系统是水凝胶。
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公开(公告)号：KR1020100114425A
公开(公告)日：2010-10-25
申请号：KR1020090032959
申请日：2009-04-15
Applicant: 포항공과대학교 산학협력단
CPC classification number: A61K9/4816 , A61K9/5146 , A61K31/337 , A61K31/506 , A61K31/704 , A61K41/0071 , A61K47/34 , A61K47/58 , A61N5/062 , Y10T428/2982
Abstract: PURPOSE: A composition containing polymer capsule for photodynamic therapy is provided to ensure photosensitized treatment effect and reduce side effect. CONSTITUTION: A composition for photodynamic therapy contains polymer capsule having diameter of 10-2000nm which is formed by polymerizing a compound of chemical formulas 1 and 2. The compound of chemical formula 1 has ethenyl(-CH=CH_2) or ethinyl group(-C≡CH). The compound of chemical formula 2 is 1,8-octanedithiol, 3,6-dioxa-1,8-octandithiol, pentaerythritol tetrakis(3-mercaptopionate), trimethylolpropane tri(3-mercapsopropionate) or mixture thereof. The composition is used for treating liver cancer, lung cancer, uterine cancer, skin cancer, brain cancer, or gastric cancer.
Abstract translation: 目的：提供含有光动力治疗聚合物胶囊的组合物，以确保光敏治疗效果，减少副作用。 构成：用于光动力学治疗的组合物含有直径为10-2000nm的聚合物胶囊，其通过聚合化学式1和化合物2的化合物形成。化学式1的化合物具有乙烯基（-CH = CH 2）或乙炔基（-C ≡CH）。 化学式2的化合物是1,8-辛二硫醇，3,6-二氧杂-1,8-辛二硫醇，季戊四醇四（3-巯基戊酸酯），三羟甲基丙烷三（3-巯基丙酸酯）或其混合物。 该组合物用于治疗肝癌，肺癌，子宫癌，皮肤癌，脑癌或胃癌。
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公开(公告)号：KR100964503B1
公开(公告)日：2010-06-21
申请号：KR1020087002687
申请日：2006-03-09
Applicant: 포항공과대학교 산학협력단
Abstract: 쿠커비투릴이 첨가된 담배가 개시된다. 개시된 쿠커비투릴이 첨가된 담배는 하기 화학식 1의 쿠커비투릴을 포함한다.
따라서, 개시된 쿠커비투릴이 첨가된 담배는 유해성분의 발생량이 저감된다.-
5.发明公开쿠커비투릴 유도체와 게스트 화합물의 비공유 결합을이용한 세포 구성 성분의 분리 및 정제 방법, 및 이를이용한 키트 有权使用CUCURBITURIL衍生物和顾客化合物之间的非共价键和使用其的装置分离和纯化细胞组分的方法
公开(公告)号：KR1020090109809A
公开(公告)日：2009-10-21
申请号：KR1020080035223
申请日：2008-04-16
Applicant: 포항공과대학교 산학협력단
IPC: C12N15/10
CPC classification number: C07K1/22
Abstract: PURPOSE: A method for isolating or purifying cellular components through non-covalent bond of cucurbituril derivative and guest compound is provided to isolate various compounds. CONSTITUTION: A method for isolating or purifying cellular components through non-covalent bond of cucurbituril derivative and guest compound comprises: a step of contacting reactive compound with cells; a step of performing lysis the cells; a step of adding solid phase which is connected with a host compound in the solution in which cells are lyzed; a step of isolating and purifying the guest compound and host compound; and a step of isolating cell component.
Abstract translation: 目的：提供通过葫芦素衍生物和客体化合物的非共价键分离或纯化细胞成分的方法以分离各种化合物。 构成：通过葫芦巴衍生物和客体化合物的非共价键分离或纯化细胞成分的方法包括：使反应性化合物与细胞接触的步骤; 细胞裂解步骤; 在将细胞溶解的溶液中添加与主体化合物连接的固相的工序; 分离和纯化客体化合物和主体化合物的步骤; 以及隔离细胞成分的步骤。
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Patent Agency Ranking6.发明公开쿠커비투릴이 결합된 실리카겔을 이용한 정지상 및 컬럼,그리고 상기 컬럼을 이용한 탁산의 분리 방법 失效使用CUCURBITURIL粘结二氧化硅凝胶的固定相和柱，以及使用柱的TAXOL分离方法
公开(公告)号：KR1020080075832A
公开(公告)日：2008-08-19
申请号：KR1020087002688
申请日：2006-03-24
Applicant: 포항공과대학교 산학협력단
Inventor： 김기문 , 박경민 , 고영호 , 셀바팔람나라야난 , 나가라잔에루마이파티알.
IPC: C07D487/04
CPC classification number: C07D487/04 , B01J20/286 , C07D305/14
Abstract: A stationary phase and column by using cucurbituril bonded silica gel are provided to separate high purity of taxane from low purity of taxane extract and reduce the costs for purification of taxane, so that high purity of taxane and paclitaxel isolated therefrom are useful for treating cancer. A stationary phase contains cucurbituril represented by the formula(1) or formula(2), in which R1 and R2 are each independently hydrogen, hydroxyl group, C1-C30 alkyloxy group, C1-C30 alkynyloxy group, C2-C30 carbonylalkyloxy group, C1-C30 thioalkyloxy group, C1-C30 alkylthioloxy group, C1-C30 hydroxyalkyloxy group, C1-C30 alkylsiloxy group, C1-C30 aminoalkyloxy group, C1-C30 aminoalkylthioalkyloxy group, C5-C30 cycloalkyloxy group, C2-C30 heterocycloalkyloxy group, C6-C30 aryloxy group, C6-C20 arylalkyloxy group, C4-C30 heteroaryloxy group, C4-C30 heteroarylalkyloxy group, C1-C30 alkylthio group, C1-C30 alkenylthio group, C1-C30alkynylthio group, C2-C30 carbonylalkylthio group, C1-C30 thioalkylthio group, C1-C30 hydroxyalkylthio group, C1-C30 alkylsilylthio group, C1-C30 aminoalkylthio group, C1-C30 aminoalkylthiolalkylthio group, C5-C30 cycloalkylthio group, C2-C30 heterocycloalkylthio group, C6-C30 arylthio group, C6-C20 arylalkylthio group, C4-C30heteroarylthio group, C4-C30 heteroarylalkylthio group, C1-C30 alkylamine group, C1-C30 alkenylamine group, C1-C30 alkynylamine group, C2-C30 carbonylalkylamine group, C1-C30 thioalkylamine group, C1-C30 hydroxyalkylamine group, C1-C30 alkylsilylamine group, C1-C30 trialkyloxysilyl alkyl-carbamate group, C1-C30 trialkyloxysilyl alkyl-thiocarbamate group, C1-C30 trialkyloxysilyl alkyloxy group, C1-C30 trialkyloxysilyl alkyl-carbonyloxy group, C1-C30 trialkyloxysilyl heteroalkyl-alkyloxy group, C1-C30 aminoalkylamine group, C1-C30 aminoalkylthioalkylamine group, C5-C30 cycloalkylamine group, C2-C30 heterocycloalkylamine group, C6-C30 arylamine group, C6-C20 arylalkylamine group, C4-C30 heteroarylamine, C4-C30 heteroarylamine group, C1-C30 alkylazide group, C1-C30 arylazide group, C1-C30 alkylcarboxylazide group or C1-C30 arylcarboxylazide group; X is O, S or NH; and n is an integer from 4 to 20, which is covalently bonded to silica gel represented by the formula(3), in which R2 is C2-C10 alkylthiol group, C2-C10 alkylamine group, C2-C10 epoxyalkyloxyalkyl group, C2-C10 isocyanatoalkyl group, C2-C10 halogenated alkyl group or hydroxyl group.
Abstract translation: 提供了使用葫芦巴键合硅胶的固定相和柱，以从紫杉烷提取物的低纯度中分离出高纯度的紫杉烷，降低了紫杉烷的纯化成本，从而分离出紫杉烷和紫杉醇的高纯度可用于治疗癌症。 固定相含有由式（1）或式（2）表示的葫芦巴脲，其中R 1和R 2各自独立地为氢，羟基，C 1 -C 30烷氧基，C 1 -C 30炔氧基，C 2 -C 30羰基烷氧基，C 1 -C30硫代烷氧基，C1-C30烷硫基氧基，C1-C30羟基烷氧基，C1-C30烷基甲硅烷氧基，C1-C30氨基烷氧基，C1-C30氨基烷硫基烷氧基，C5-C30环烷氧基，C2-C30杂环烷氧基，C6-C30 芳氧基，C 6〜C 20芳烷氧基，C 4〜C 30杂芳氧基，C 4〜C 30杂芳基烷氧基，C 1 -C 30烷硫基，C 1 -C 30烯硫基，C 1 -C 30炔硫基，C 2〜C 30羰基烷硫基，C 1 -C 30硫代烷硫基， C1-C30羟烷基硫基，C1-C30烷基甲硫基，C1-C30氨基烷硫基，C1-C30氨基烷硫基烷硫基，C5-C30环烷基硫基，C2-C30杂环烷硫基，C6-C30芳硫基，C6-C20芳烷硫基， C30杂芳基硫基，C4-C30杂 芳基烷硫基，C1-C30烷基胺基，C1-C30链烯基胺基，C1-C30炔基胺基，C2-C30羰基烷基胺基，C1-C30硫代烷基胺基，C1-C30羟烷基胺基，C1-C30烷基甲硅烷基胺基，C1-C30三烷基甲硅烷基烷基 氨基甲酸酯基，C1-C30三烷氧基甲硅烷基烷基 - 硫代氨基甲酸酯基，C1-C30三烷氧基甲硅烷基烷氧基，C1-C30三烷氧基甲硅烷基烷基 - 羰基氧基，C1-C30三烷基甲硅烷基杂烷基 - 烷氧基，C1-C30氨基烷基胺基，C1-C30氨基烷硫基烷基胺基， C 5 -C 30环烷基胺基，C 2 -C 30杂环烷基胺基，C 6 -C 30芳基胺基，C 6 -C 20芳烷基胺基，C 4 -C 30杂芳基胺，C 4 -C 30杂芳基胺基，C 1 -C 30烷基叠氮基，C 1 -C 30芳基叠氮基，C 1 -C 30 烷基羧基叠氮基或C 1 -C 30芳基羧基叠氮基; X是O，S或NH; 和n为4〜20的整数，与式（3）表示的硅胶共价键合，其中R2为C2-C10烷基硫醇基，C2-C10烷基胺基，C2-C10环氧烷氧基烷基，C2-C10 异氰酸根合烷基，C 2 -C 10卤代烷基或羟基。
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公开(公告)号：KR1020080073134A
公开(公告)日：2008-08-08
申请号：KR1020070011761
申请日：2007-02-05
Applicant: 포항공과대학교 산학협력단
CPC classification number: B01D53/04 , B01D2253/20 , B01D2257/104 , B01D2257/7022 , C01B13/02 , C07C7/12 , F17C11/005 , F17C11/007 , C07C11/24
Abstract: A method for storing or separating acetylene is provided to store a large amount of acetylene safely even at low temperature or ambient temperature, and to produce high-purity acetylene gas by using a metal-formate porous crystal material. A storage method of acetylene includes a step of bringing acetylene or an acetylene-containing gas mixture into contact with a metal-formate porous crystal material represented by the following structural formula 1 to adsorb the acetylene. In the formula 1, each formate ion is bonded to three metal ion(M)s, each metal ion is bonded to six formate ions, a compositional ratio of the metal ion(M) and formate ion is 1:2, and the metal is Mg, Mn, Co, Zn, or Fe.
Abstract translation: 提供了存储或分离乙炔的方法，即使在低温或环境温度下也能安全地储存大量的乙炔，并且通过使用金属 - 甲酸盐多孔结晶材料生产高纯度的乙炔气体。 乙炔的储存方法包括使乙炔或含乙炔的气体混合物与由以下结构式1表示的金属 - 甲酸盐多孔结晶材料接触以吸附乙炔的步骤。 在式1中，每个甲酸根离子结合到三个金属离子（M）上，每个金属离子与六个甲酸根离子结合，金属离子（M）和甲酸根离子的组成比为1:2，金属 是Mg，Mn，Co，Zn或Fe。
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公开(公告)号：KR101118586B1
公开(公告)日：2012-02-27
申请号：KR1020090032959
申请日：2009-04-15
Applicant: 포항공과대학교 산학협력단
CPC classification number: A61K9/4816 , A61K9/5146 , A61K31/337 , A61K31/506 , A61K31/704 , A61K41/0071 , A61K47/34 , A61K47/58 , A61N5/062 , Y10T428/2982
Abstract: 하기 화학식 1로 표시되는 화합물 및 하기 화학식 2로 표시되는 유기 화합물이 공중합하여 형성된 직경 10 내지 2000 nm 크기의 고분자 캡슐을 포함하는 광역학 치료용 조성물을 제공한다:
[화학식 1]
[화학식 2]
(HS)
j -Z-(SH)
k
상기 화학식 1 및 2에서, A, B, Z, m, j, 및 k는 명세서에서 정의된 바와 같다.-
公开(公告)号：KR1020110081654A
公开(公告)日：2011-07-14
申请号：KR1020100001914
申请日：2010-01-08
Applicant: 포항공과대학교 산학협력단
IPC: C07D487/04 , A01P1/00
Abstract: PURPOSE: A giant multimeric carbohydrate in which two or more multimeric carbohydrates are bonded to a single anchoring agent is provided to be used as a protein inhibitor. CONSTITUTION: A giant multimeric carbohydrate in which two more multimeric carbohydrate are bonded to a single anchoring agent is formed by covalent bond of one or more carbohydrate derivative with cucurbitruil derivative single molecule A1 or A2 of chemical formula 1. The carbohydrate derivative is monosaccharide, disaccharide, or polysaccharide. A protein inhibitor contains the giant multimeric carbohydrate. An anti-adherent of microorganism contains the giant multimeric carbohydrate.
Abstract translation: 目的：提供将两种或多种多聚体碳水化合物结合到单一锚定剂上的巨型多聚体碳水化合物用作蛋白质抑制剂。 构成：通过一种或多种碳水化合物衍生物与化学式1的葫芦巴瑞衍生物单分子A1或A2的共价键形成两个多聚多糖碳水化合物结合到单个锚定剂的巨型多聚体碳水化合物。碳水化合物衍生物是单糖，二糖 ，或多糖。 蛋白质抑制剂含有巨型多聚体碳水化合物。 微生物的抗粘附物含有巨型多聚体碳水化合物。
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10.发明授权쿠커비투릴 유도체와 게스트 화합물의 비공유 결합을이용한 세포 구성 성분의 분리 및 정제 방법, 및 이를이용한 키트 有权使用葫芦素衍生物和客体化合物之间的非共价键分离和纯化细胞成分的方法和使用其的装置
公开(公告)号：KR101008536B1
公开(公告)日：2011-01-14
申请号：KR1020080035223
申请日：2008-04-16
Applicant: 포항공과대학교 산학협력단
IPC: C12N15/10
CPC classification number: C07K1/22
Abstract: 본 발명은 세포 구성 성분의 분리 방법으로서, a) 게스트(guest) 화합물이 연결된 반응성 화합물을 세포와 접촉시키는 단계; b) 상기 세포를 용해시키는 단계; c) 상기 세포가 용해된 용액에 호스트(host) 화합물이 연결된 고체상(solid phase)을 첨가하여 혼합액을 준비하는 단계; d) 상기 혼합액으로부터 세포 구성 성분에 연결된 게스트 화합물과 고체상에 연결된 호스트 화합물의 결합쌍(binding pair)을 분리, 정제하는 단계; 및 e) 상기 결합쌍으로부터 상기 세포 구성 성분을 분리하는 단계;를 포함하며, 상기 게스트 화합물이 연결된 반응성 화합물은 반응성 화합물과 하기 화학식 2의 게스트 화합물이 공유결합된 것이며, 상기 호스트 화합물이 연결된 고체상은 고체상과 하기 화학식 1의 호스트 화합물이 공유결합된 것이며, 상기 반응성 화합물이 생체 성분, N-하이드록시석신이미드, 항원, 항체, 압타머(aptamer), 엽산 및 트랜스페린으로 이루어지는 군에서 선택된 하나 이상의 화합물인 방법을 제공한다.
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