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公开(公告)号：WO2016171529A1
公开(公告)日：2016-10-27
申请号：PCT/KR2016/004295
申请日：2016-04-25
Applicant: 포항공과대학교 산학협력단
IPC: A61M37/00 , A61K39/395
CPC classification number: B29D11/00096 , A61F9/0017 , A61K39/395 , A61M37/00 , G02B2027/0178 , G02C7/04 , G02C7/085 , G02C7/086
Abstract: 본 발명은 안 질환을 실시간으로 비 침습적으로 감지할 수 있는 센서와 약물전달소를 포함하는 스마트 콘택트 렌즈, 및 상기 스마트 콘택트 렌즈를 제어하는 스마트 안경을 제공한다.
Abstract translation: 本发明提供：包括用于实时非侵入性地感测眼部疾病的传感器的智能隐形眼镜和药物递送元件; 和用于控制智能隐形眼镜的智能眼镜。
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2.发明申请12량체 TRAIL 및 HSV-TK 자살유전자를 동시에 발현하는 벡터 및 이를 이용한 항암 줄기세포 치료제 审中-公开载体同时表达多克隆TRAIL和HSV-TK杀菌剂基因，以及使用相同抗原的干细胞治疗剂
公开(公告)号：WO2013115608A1
公开(公告)日：2013-08-08
申请号：PCT/KR2013/000849
申请日：2013-02-01
Applicant: 포항공과대학교 산학협력단 , 주식회사 바이오드
IPC: C12N15/12 , C12N15/861 , C12N7/01 , A61K35/12
CPC classification number: A61K38/191 , A61K35/12 , A61K38/00 , A61K48/00 , A61K48/005 , C07K14/525 , C07K2319/02 , C12N2710/10343 , C12N2800/22 , C12N2830/003 , C12Y207/01021
Abstract: 본 발명은 12량체 TRAIL을 암호화하는 핵산서열 및 자살유전자 핵산서열을 포함하는 DNA 카세트, 상기 DNA 카세트를 포함하는 재조합 발현벡터, 상기 재조합 발현벡터를 이용하여 제조된 재조합 아데노바이러스, 상기 재조합 아데노바이러스로 형질감염된 숙주세포, 상기 숙주세포를 포함하는 암 치료용 조성물, 및 상기 암 치료용 조성물을 개체에 투여하는 단계를 포함하는 암 치료 방법에 관한 것이다. 본 발명의 DNA 카세트가 도입되어 12량체 TRAIL 및 HSV-TK를 동시에 생산하는 줄기세포 치료제는 기존 치료제에 비하여 항암 효과가 보다 우수하므로, 다양한 고형암 및 전이암 치료에 효과적으로 이용할 수 있다.
Abstract translation: 本发明涉及：包含编码十二聚体TRAIL和自杀基因核酸序列的核酸序列的DNA盒; 包含DNA盒的重组表达载体; 使用重组表达载体制备的重组腺病毒; 通过重组腺病毒转染的宿主细胞; 用于治疗癌症的组合物，其包含所述宿主细胞; 以及癌症治疗方法，其包括向个体施用治疗癌症的组合物的步骤。 通过引入本发明的DNA盒同时产生十二聚体TRAIL和HSV-TK的干细胞治疗剂与现有治疗剂相比具有优异的抗癌作用，因此可有效地用于治疗各种固体 癌症和转移性癌症。
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公开(公告)号：KR101812611B1
公开(公告)日：2017-12-28
申请号：KR1020160050139
申请日：2016-04-25
Applicant: 포항공과대학교 산학협력단 , 한국과학기술원
CPC classification number: B29D11/00096 , A61F9/0017 , A61K39/395 , A61M37/00 , G02B2027/0178 , G02C7/04 , G02C7/085 , G02C7/086
Abstract: 본발명은안 질환을실시간으로비 침습적으로감지할수 있는센서와약물전달소를포함하는스마트콘택트렌즈, 및상기스마트콘택트렌즈를제어하는스마트안경을제공한다.
Abstract translation: 本发明提供了一种智能眼镜用于控制智能接触透镜，并且其中，所述智能隐形眼镜，包括一个传感器和一个药物递送不能检测到在实时非侵入性牛的疾病。
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公开(公告)号：KR1020160127322A
公开(公告)日：2016-11-03
申请号：KR1020160050139
申请日：2016-04-25
Applicant: 포항공과대학교 산학협력단 , 한국과학기술원
CPC classification number: B29D11/00096 , A61F9/0017 , A61K39/395 , A61M37/00 , G02B2027/0178 , G02C7/04 , G02C7/085 , G02C7/086
Abstract: 본발명은안 질환을실시간으로비 침습적으로감지할수 있는센서와약물전달소를포함하는스마트콘택트렌즈, 및상기스마트콘택트렌즈를제어하는스마트안경을제공한다.
Abstract translation: 本发明提供：包括用于实时非侵入性地感测眼部疾病的传感器的智能隐形眼镜和药物递送元件; 和用于控制智能隐形眼镜的智能眼镜。
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公开(公告)号：KR101132749B1
公开(公告)日：2012-04-06
申请号：KR1020090050203
申请日：2009-06-08
Applicant: 포항공과대학교 산학협력단
Abstract: PURPOSE: A refrigerator door guard assembly structure, capable of convenient attachment and detachment, is provided to efficiently and conveniently attach and detach a door guard by supplying the visual information about the assembly spot of the door guard. CONSTITUTION: A refrigerator door guard assembly structure(300) comprises an assemblage groove and an assembling protrusion(320a). The assemblage groove is formed in the inner surface of both sides of the refrigerator door. The upper side of the assemblage groove is formed in an arc shape. The assembling protrusion is formed on the outer side of the door guard. The assembling protrusion comprises a vertical face formed on a curved face.
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Patent Agency Ranking
公开(公告)号：KR1020140090287A
公开(公告)日：2014-07-17
申请号：KR1020120145758
申请日：2012-12-13
Applicant: 포항공과대학교 산학협력단 , 주식회사 제넥신
IPC: A61K9/06 , A61K31/728
CPC classification number: A61K31/728 , A61K9/06 , A61K31/203 , A61K31/573
Abstract: The present invention relates to hyaluronic acid-based hydrogel including a cell differentiating agent or a cell activity inducing material and produced using cucurbituril and polyamine, a cell treatment-assisting composition including the hydrogel, a cell treating composition including the hydrogel including a cell differentiating agent or a cell activity inducing material and mesenchymal stem cells, and a cell treatment-assisting composition including the hyaluronic acid-based hydrogel produced using cucurbituril and polyamine. Another purpose of the present invention relates to a cell treatment composition including the hydrogel and mesenchymal stem cells. The hyaluronic acid-based hydrogel provided in the present invention plays a role as a supplementary material for supporting stem cells which expresses a treatment material used as a cell treatment agent so as to promote the secretion of the treatment material and increase cell survival rates, so that the treatment effects of the cell treatment agent can be maximized. Accordingly, the hyaluronic acid-based hydrogel can be widely used to develop a cell treatment agent which exhibits improved effects.
Abstract translation: 本发明涉及包含细胞分化剂或细胞活性诱导材料并使用葫芦巴和多胺制备的透明质酸系水凝胶，包含该水凝胶的细胞治疗辅助组合物，包含水凝胶的细胞处理组合物，其包含细胞分化剂 或细胞活性诱导材料和间充质干细胞，以及包含使用葫芦巴和多胺制备的透明质酸类水凝胶的细胞治疗辅助组合物。 本发明的另一个目的涉及包含水凝胶和间充质干细胞的细胞处理组合物。 本发明中提供的透明质酸水凝胶作为支持干细胞的辅助材料起作用，其表达用作细胞处理剂的处理材料，以促进处理材料的分泌并增加细胞存活率，因此 可以使细胞处理剂的处理效果最大化。 因此，透明质酸系水凝胶可广泛用于开发显示改善效果的细胞处理剂。
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公开(公告)号：KR1020090087353A
公开(公告)日：2009-08-17
申请号：KR1020080012745
申请日：2008-02-12
Applicant: 포항공과대학교 산학협력단
CPC classification number: B82B3/0038 , B82Y40/00 , C08J5/005
Abstract: A manufacturing method of a nano structure using self-assembled block copolymer is provided to easily form a nano structure on a metal surface. A manufacturing method of a nano structure using self-assembled block copolymer comprises the following steps: a step for forming a metal thin film on a substrate(a); a step for treating a surface of the metal thin film using oxygen plasma(b); a step for neutralizing the surface of the metal thin film(c); a step for coating a block copolymer on the surface(d); and a step for forming a self-assembled nano structure by annealing and exposing the block copolymer(e).
Abstract translation: 提供使用自组装嵌段共聚物的纳米结构的制造方法，以容易地在金属表面上形成纳米结构。 使用自组装嵌段共聚物的纳米结构体的制造方法包括以下步骤：在基板（a）上形成金属薄膜的工序。 使用氧等离子体（b）处理金属薄膜的表面的步骤; 中和金属薄膜（c）的表面的步骤; 在表面（d）上涂布嵌段共聚物的步骤; 以及通过退火和暴露嵌段共聚物（e）形成自组装纳米结构的步骤。
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公开(公告)号：KR102053385B1
公开(公告)日：2019-12-06
申请号：KR1020130012051
申请日：2013-02-01
Applicant: 포항공과대학교 산학협력단 , 주식회사 에스엘바이젠
IPC: C12N15/12 , C12N15/861 , C12N7/01 , A61K35/12
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9.发明公开12량체 ＴＲＡＩＬ 및 ＨＳＶ-ＴＫ 자살유전자를 동시에 발현하는 벡터 및 이를 이용한 항암 줄기세포 치료제 审中-实审载体共转染多克隆TRAIL和SUICIDE基因HSV-TK及其使用的抗原干细胞药物
公开(公告)号：KR1020130089214A
公开(公告)日：2013-08-09
申请号：KR1020130012051
申请日：2013-02-01
Applicant: 포항공과대학교 산학협력단 , 주식회사 에스엘바이젠
IPC: C12N15/12 , C12N15/861 , C12N7/01 , A61K35/12
CPC classification number: A61K38/191 , A61K35/12 , A61K38/00 , A61K48/00 , A61K48/005 , C07K14/525 , C07K2319/02 , C12N2710/10343 , C12N2800/22 , C12N2830/003 , C12Y207/01021
Abstract: PURPOSE: An anticancer stem cell medicine is provided to have an excellent anticancer effect compared with the existing drug, thereby being used effectively for treatment of various solid cancers and metastatic cancers. CONSTITUTION: A DNA cassette includes the respective nucleic acid sequence for coding dodecameric TRAIL (TNF related apoptosis inducing ligand) and suicide gene. A recombinant expression vector comprises the DNA cassette. The recombinant expression vector is derived from adenovirus. The recombinant adenovirus is made by the recombinant expression vector. The host cell is transfected with the recombinant adenovirus. The anticancer medicine contains the host cell. [Reference numerals] (AA) Survival rate after repeated MSC/dTRAIL-TK injection; (BB) Survival rate (%); (CC) Period (Day) after injecting tumor
Abstract translation: 目的：提供抗癌干细胞药物与现有药物相比具有优异的抗癌作用，从而有效地用于治疗各种固体癌症和转移性癌症。 构成：DNA盒包括用于编码十二聚体TRAIL（TNF相关凋亡诱导配体）和自杀基因的各自的核酸序列。 重组表达载体包含DNA盒。 重组表达载体来源于腺病毒。 重组腺病毒由重组表达载体制备。 宿主细胞用重组腺病毒转染。 抗癌药含有宿主细胞。 （附图标记）（AA）重复MSC / dTRAIL-TK注射后的存活率; （BB）生存率（％）; （CC）注射肿瘤后的时间（天）
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公开(公告)号：KR101605528B1
公开(公告)日：2016-03-23
申请号：KR1020120145758
申请日：2012-12-13
Applicant: 포항공과대학교 산학협력단 , 주식회사 제넥신
IPC: A61K9/06 , A61K31/728
Abstract: 본발명은세포분화제또는세포활성유도물질을포함하고, 쿠커비투릴과폴리아민을이용하여제조된히알루론산기반하이드로겔, 상기하이드로겔을포함하는세포치료보조용조성물, 상기세포분화제또는세포활성유도물질을포함하는하이드로겔과중간엽줄기세포를포함하는세포치료용조성물, 쿠커비투릴과폴리아민을이용하여제조된히알루론산기반하이드로겔을포함하는세포치료보조용조성물및 본발명의또 다른목적은상기하이드로겔과중간엽줄기세포를포함하는세포치료용조성물에관한것이다. 본발명에서제공하는히알루론산기반하이드로겔은세포치료제로서사용되는치료물질을발현시키는줄기세포를지지하는보조제로서의역할을수행하여, 상기치료물질의분비를촉진시키고, 세포생존율을증가시켜서세포치료제의치료효과를극대화시킬수 있으므로, 보다향상된효능을나타내는세포치료제의개발에널리활용될수 있을것이다.
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