公开(公告)号：KR1020110032561A

公开(公告)日：2011-03-30

申请号：KR1020090090113

申请日：2009-09-23

Applicant: 포항공과대학교 산학협력단

Inventor： 한세광 ,  허원희 ,  김지석 ,  김기수 ,  윤승규

IPC: A61K47/36 ,  A61P1/16

CPC classification number: A61K47/36 ,  A61K47/61 ,  A61K49/0054 ,  A61K49/0067

Abstract: PURPOSE: A method for controlling target-specificity of a drug delivery system containing a hyaluronic acid derivative is provided to control carboxyl group substitution rate. CONSTITUTION: A target specificity of a drug delivery system containing hyaluronic acid derivatives is controlled by regulating carboxyl group substitution rate of hyaluronic acid derivatives. A target receptor of the drug delivery system is CD44, LYVE-1, RHAMM, or HARE. The drug delivery system contains hyaluronic acid derivatives in which 5 mole%-45mole% of substituted carboxyl group. The drug delivery system contains encapsulated or sealed drug for preventing or treating liver diseases.

Abstract translation: 目的：提供一种控制含有透明质酸衍生物的药物递送系统靶特异性的方法，以控制羧基取代率。 构成：通过调节透明质酸衍生物的羧基取代率来控制含有透明质酸衍生物的药物递送系统的靶特异性。 药物递送系统的靶受体是CD44，LYVE-1，RHAMM或HARE。 药物递送系统含有5mol％-45mol％的取代羧基的透明质酸衍生物。 药物递送系统包含用于预防或治疗肝脏疾病的包封或密封药物。