公开(公告)号：KR1020110022535A

公开(公告)日：2011-03-07

申请号：KR1020100081315

申请日：2010-08-23

Applicant: 포항공과대학교 산학협력단 ,  삼성전자주식회사

Inventor： 전상민 ,  서혜정 ,  이수석

IPC: G01N33/48 ,  G01N21/25 ,  G01N33/553

Abstract: PURPOSE: A method for detecting biomolecules and a sensor using nanoparticle enrichment are provided to effectively detect mass change. CONSTITUTION: A method for detecting biomolecule binding comprises: a step of reacting a target biomolecule to a sensor for detecting mass change according to the target biomolecule binding; a step of binding the target biomolecule with optical catalyst nanoparticles; and a step of irradiating light to the optical catalyst nanoparticles to enhance mass. The optical catalyst nanoparticle promotes oxidation-reduction of metal ion. The light is UV ray or visible ray. The metal ion is silver ion, copper ion, gold ion, or palladium ion. The sensor is surface acoustic wave sensor, or surface Plasmon resonance(SPR).

Abstract translation: 目的：提供检测生物分子的方法和使用纳米颗粒富集的传感器，以有效检测质量变化。 构成：用于检测生物分子结合的方法包括：将目标生物分子与传感器反应以根据目标生物分子结合检测质量变化的步骤; 将目标生物分子与光催化剂纳米颗粒结合的步骤; 以及向光学催化剂纳米颗粒照射光以提高质量的步骤。 光学催化剂纳米颗粒促进金属离子的氧化还原。 光线是紫外线或可见光线。 金属离子是银离子，铜离子，金离子或钯离子。 传感器是表面声波传感器，或表面等离子体共振（SPR）。

公开(公告)号：KR1020130015634A

公开(公告)日：2013-02-14

申请号：KR1020110077737

申请日：2011-08-04

Applicant: 삼성전자주식회사 ,  포항공과대학교 산학협력단

Inventor： 이수석 ,  전상민 ,  서혜정 ,  최윤석 ,  이정남 ,  이준형 ,  한경연 ,  박진영 ,  이동규

IPC: G01N33/53 ,  G01N33/68 ,  C12Q1/00 ,  G01N27/72

CPC classification number: G01N27/72 ,  G01N27/745 ,  G01N33/54346

Abstract: PURPOSE: A biosensor using the aggregation of magnetic nanoparticles and a detecting method using the same are provided to quickly and sensitively detect a target material. CONSTITUTION: A biosensor comprises: a substrate(100) with a receptor(200) which specifically reacts with a target material(300); a first magnetic nanoparticle(400) with the same receptor; a magnetic field supply unit which applies a magnetic field to the first magnetic nanoparticle; and a second magnetic particle(600) which aggregates with the first magnetic nanoparticle. The target material is an enzyme substrate, a ligand, an antigen, an antibody, a nucleotide, an amino acid, a peptide, a protein, a nucleic acid, lipid, carbohydrate, an organic compound, or an inorganic compound. The first and second magnetic nanoparticles are independently a ferromagnetic or paramagnetic nanoparticle.

Abstract translation: 目的：提供使用磁性纳米粒子聚集的生物传感器和使用其的检测方法，以快速且敏感地检测目标材料。 构成：生物传感器包括：具有与靶材料（300）特异性反应的受体（200）的基底（100）; 具有相同受体的第一磁性纳米颗粒（400） 向第一磁性纳米颗粒施加磁场的磁场供给单元; 和与第一磁性纳米颗粒聚集的第二磁性颗粒（600）。 靶材料是酶底物，配体，抗原，抗体，核苷酸，氨基酸，肽，蛋白质，核酸，脂质，碳水化合物，有机化合物或无机化合物。 第一和第二磁性纳米颗粒独立地是铁磁性或顺磁性纳米颗粒。

公开(公告)号：KR1020120094259A

公开(公告)日：2012-08-24

申请号：KR1020110013641

申请日：2011-02-16

Applicant: 삼성전자주식회사 ,  포항공과대학교 산학협력단

Inventor： 이수석 ,  서혜정 ,  전상민 ,  최윤석 ,  이헌주 ,  이정남 ,  이준형 ,  한경연 ,  김상규 ,  이열호 ,  도재필

IPC: B82B3/00 ,  B82Y5/00 ,  B82Y15/00

CPC classification number: G01N33/54373 ,  B82Y15/00 ,  B82Y30/00 ,  B82Y40/00 ,  G01N33/54346

Abstract: PURPOSE: A mass reinforcing method of gold nano-particles due to light irradiation, a biosensor, and biomolecule combining detection method using the same are provided to reinforce mass of the gold nano-particles by using an optical irradiation method. CONSTITUTION: A mass reinforcing method of gold nano-particles due to light irradiation comprises the following steps: irradiating a mixture including gold nano-particles(13) and reinforcing metal component(15) with light; and increasing the mass of the gold nano-particles by reducing thereof on the surface of the gold nano-particles. The light is ultraviolet ray. The metal reinforcing component is metallic ion. A bio molecular combining detection method comprises the following steps: reacting target bio molecular with bio sensors which detect physical property changes according to bondage of the target bio molecular; combining the gold nano-particle to the target bio molecular; dipping the bio sensor into a mixture which includes the metal reinforcing components and irradiating light; and detecting physical property change of the gold nano-particles.

Abstract translation: 目的：提供由光照射引起的金纳米颗粒的质量增强方法，生物传感器和使用其的生物分子组合检测方法，以通过使用光学照射方法来增强金纳米颗粒的质量。 构成：由于光照射而导致的金纳米颗粒的质量增强方法包括以下步骤：用光照射包含金纳米颗粒（13）和增强金属成分（15）的混合物; 并且通过在金纳米颗粒的表面上还原金纳米颗粒的质量来增加金纳米颗粒的质量。 光线是紫外线。 金属增强部件是金属离子。 生物分子组合检测方法包括以下步骤：使靶生物分子与生物传感器反应，根据目标生物分子的结合检测物理性质变化; 将金纳米颗粒与目标生物分子结合; 将生物传感器浸入包括金属增强组分和照射光的混合物中; 并检测金纳米粒子的物理性质变化。

公开(公告)号：KR1020090107390A

公开(公告)日：2009-10-13

申请号：KR1020080032892

申请日：2008-04-08

Applicant: 포항공과대학교 산학협력단

Inventor： 전상민 ,  정남철 ,  서혜정

IPC: G01N25/00 ,  G01N25/02 ,  B82Y35/00

CPC classification number: G01N25/12 ,  B82Y35/00 ,  G01N33/442

Abstract: PURPOSE: A polymer measuring method using a micro cantilever is provided to measure very minute sample and facilitate controlling temperature and measure the large amount of the sample rapidly by measuring lots of samples at once. CONSTITUTION: A polymer measuring method using a micro cantilever comprises following steps. A micro cantilever array equipped with cantilevers is mounted on a flow stage. The length of the cantilever is 500 micron, and the breadth is 100 micron, and the thickness is 1 micron. A heater and a thermocouple are mounted on the array. The temperature is adjusted by attaching a heater controller. A helium-neon laser apparatus is attached and the bending degree of the cantilever is measured by the deflection.

Abstract translation: 目的：提供使用微悬臂梁的聚合物测量方法来测量非常微小的样品，并有助于控制温度，并通过一次测量大量样品来快速测量大量的样品。 构成：使用微悬臂梁的聚合物测量方法包括以下步骤。 装有悬臂的微悬臂阵列安装在流动台上。 悬臂的长度为500微米，宽度为100微米，厚度为1微米。 阵列上安装有加热器和热电偶。 通过安装加热器控制器来调节温度。 安装氦氖激光装置，通过偏转来测量悬臂的弯曲度。

公开(公告)号：KR100823516B1

公开(公告)日：2008-04-21

申请号：KR1020060115070

申请日：2006-11-21

Applicant: 포항공과대학교 산학협력단

Inventor： 전상민 ,  서혜정 ,  정성혜

IPC: G01N27/04 ,  G01N27/00

Abstract: A formaldehyde sensor using a piezo-resistive cantilever is provided to predict sick house syndrome in advance by selectively detecting formaldehyde for preparing against the sick house syndrome. A formaldehyde sensor using a piezo-resistive cantilever includes a cantilever(1), a gold coating film(6), and a mercaptophenol. The cantilever is fixed on a measurement chip(2) and includes a piezo-resistive unit(3). A wheatston bridge is embedded in the measurement chip. The piezo-resistive unit is R1 of the wheatston bridge being connected with R2, R3, and R4 through an electrical connector(5), is dopped and inserted in an upper part of a central shaft, and is folded with the cantilever when the cantilever is folded. The gold coating film is formed on an upper surface of the cantilever for sticking the mercaptophenol thereon. The mercaptophenol detects formaldehyde.

Abstract translation: 提供使用压电悬臂的甲醛传感器，通过选择性检测甲醛来预防病房综合征，预测病房综合征。 使用压阻悬臂的甲醛传感器包括悬臂（1），金涂膜（6）和巯基苯酚。 悬臂固定在测量芯片（2）上，并包括压阻单元（3）。 小麦斯顿桥嵌入测量芯片。 压电单元是通过电连接器（5）与R2，R3和R4连接的Wheatston桥的R1，被掺杂并插入到中心轴的上部中，并且当悬臂被折叠时与悬臂折叠 被折叠 金涂膜形成在悬臂的上表面上，用于将巯基苯酚粘附在其上。 巯基苯酚检测甲醛。