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    고체 기판 상에서 표면 결합된 올리고뉴클레오타이드를 제조하는 방법 및 이의 용도
    2.
    发明公开
    고체 기판 상에서 표면 결합된 올리고뉴클레오타이드를 제조하는 방법 및 이의 용도 无效
    在固体基底上生产表面结合的寡核苷酸的方法及其用途

    公开(公告)号：KR1020120119909A

    公开(公告)日：2012-10-31

    申请号：KR1020127015322

    申请日：2009-11-16

    Applicant: 포항공과대학교 산학협력단

    Inventor： 박준원 ,  홍봉진 ,  김덕회

    IPC: C12Q1/68 ,  C12N15/11

    CPC classification number: C12Q1/6837 ,  B01J2219/00387 ,  B01J2219/00509 ,  B01J2219/00529 ,  B01J2219/00608 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00653 ,  B01J2219/00722 ,  C40B80/00 ,  G01Q60/42 ,  C12Q1/6806 ,  B82Y30/00 ,  B82Y35/00 ,  B82Y40/00 ,  C12Q2565/601 ,  C12Q2537/113 ,  C12Q2533/107

    Abstract: PURPOSE: A manufacturing method of oligonucleotide which is surface combined on a solid surface is provided to manufacture one piece of oligonucleotide probe by covalently bonding the non-bonded oligonucleotide. CONSTITUTION: A manufacturing method of oligonucleotide which are surface combined on a solid surface comprises the following steps: contacting a first oligonucleotide with a target oligonucleotide which includes oligonucleotide sequence corresponding to the first oligonucleotide sequence under a condition which is enough for manufacturing oligonucleotide complex; contacting partially mixed oligonucleotide combination with a second oligonucleotide including the oligonucleotide sequence which corresponds with non-mixed part of the target oligonucleotide; and manufacturing oligonucleotide combination which includes the surface combined oligonucleotide. [Reference numerals] (AA) Hybridization; (BB) Leading DNA; (CC) Target DNA

    Abstract translation: 目的：提供在固体表面上表面组合的寡核苷酸的制造方法，以通过共价键合非键合的寡核苷酸制造一片寡核苷酸探针。 构成：表面组合在固体表面上的寡核苷酸的制造方法包括以下步骤：在足以制造寡核苷酸复合物的条件下使第一寡核苷酸与包含与第一寡核苷酸序列对应的寡核苷酸序列的靶寡核苷酸接触; 使部分混合的寡核苷酸组合与包含与靶寡核苷酸的非混合部分相对应的寡核苷酸序列的第二寡核苷酸接触; 并制备包含表面结合寡核苷酸的寡核苷酸组合。 （附图标记）（AA）杂交; （BB）领先DNA; （CC）靶DNA

    원자현미경을 이용한 생체분자간 결합
    3.
    发明公开
    원자현미경을 이용한 생체분자간 결합 有权
    使用原子力显微镜的生物分子相互作用

    公开(公告)号：KR1020110028565A

    公开(公告)日：2011-03-18

    申请号：KR1020117005477

    申请日：2006-08-14

    Applicant: 주식회사 포스코 ,  포항공과대학교 산학협력단

    Inventor： 박준원 ,  정유진 ,  홍봉진 ,  김일홍 ,  박진규 ,  류성호 ,  이혜영

    IPC: G01Q60/24 ,  G01N33/50 ,  C12Q1/68

    CPC classification number: C12Q1/6816 ,  G01Q60/42 ,  G01Q60/24 ,  C12Q1/6834 ,  C12Q2565/601

    Abstract: PURPOSE: Biomolecule interaction using an atomic force microscopy is provided to obtain a cantilever with fixed end and free end, the surface of which is chemically transformed due to dendrons. CONSTITUTION: A cantilever(50) includes fixed end and free end. The surface of the free end is chemically transformed due to the combination with respect to ends in the branched part of dendrons. The ends in the linear part of the dendrons are combined by probe nucleotide. A target nucleotide is fixed to a substrate(20). A modulator modulates the relative position and direction of the cantilever and the substrate. A detector measures a physical variable related to the combination of the probe and target nucleotides.

    Abstract translation: 目的：提供使用原子力显微镜的生物分子相互作用，以获得具有固定端和自由端的悬臂，其表面由于树枝状化学而被化学转化。 构成：悬臂（50）包括固定端和自由端。 由于相对于树枝状突起的分支部分中的末端的组合，自由端的表面被化学转化。 通过探针核苷酸将树突状物的线性部分的末端组合。 靶核苷酸被固定到基底（20）上。 调制器调制悬臂和基板的相对位置和方向。 检测器测量与探针和靶核苷酸的组合相关的物理变量。

    원자현미경을 이용한 생체분자간 결합
    4.
    发明公开
    원자현미경을 이용한 생체분자간 결합 有权
    使用原子力显微镜的生物分子相互作用

    公开(公告)号：KR1020080052587A

    公开(公告)日：2008-06-11

    申请号：KR1020087006105

    申请日：2006-08-14

    Applicant: 주식회사 포스코 ,  포항공과대학교 산학협력단

    Inventor： 박준원 ,  정유진 ,  홍봉진 ,  김일홍 ,  박진규 ,  류성호 ,  이혜영

    IPC: G01N23/00 ,  G01N33/50 ,  C12Q1/68

    CPC classification number: C12Q1/6816 ,  G01Q60/42 ,  B82Y35/00 ,  C12Q2565/601 ,  G01N33/50

    Abstract: Biomolecule interaction using an atomic force microscope is provided to analyze ligand-receptor interaction by fixing a ligand at the tip of the atomic force microscope using dendron. A cantilever for an atomic force microscope comprises a main body with a fixed end and a free end. The free end has a surface chemically deformed by dendron. The ends located on a basin of the dendron are coupled to the deformed surface. The end of linear portion of the dendron has become a functional group.

    Abstract translation: 提供使用原子力显微镜的生物分子相互作用，通过使用树枝状结构在原子力显微镜的尖端固定配体来分析配体 - 受体相互作用。 原子力显微镜的悬臂包括具有固定端和自由端的主体。 自由端具有通过树枝状化学变形的表面。 位于树突的盆地上的端部与变形的表面相连。 树突的直线部分的末端已经成为一个官能团。

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