公开(公告)号：KR100458418B1

公开(公告)日：2004-11-26

申请号：KR1020020051780

申请日：2002-08-30

Applicant: 학교법인연세대학교

Inventor： 신전수 ,  윤주호 ,  조상래

IPC: C07K7/06

Abstract: PURPOSE: Mimotope peptides of phenolic glycolipid-I(PGL-I) of Mycobacterium leprae and a kit for serodiagnosis of leprosy containing the same are provided, thereby substituting expensive PGL-I with the cheap mimotope peptide of PGL-I. Therefore, the cost for serodiagnosis of leprosy can be decreased. CONSTITUTION: Mimotope peptides of phenolic glycolipid-I(PGL-I) of Mycobacterium leprae have the amino acid sequence of WTLGPYV, WRLGPYV or WTLGPYM. A conjugate of the mimotope peptides of phenolic glycolipid-I(PGL-I) of Mycobacterium leprae and bovine serum albumin(BSA) is provided. A kit for serodiagnosis of leprosy contains the mimotope peptides of phenolic glycolipid-I(PGL-I) of Mycobacterium leprae or the conjugate of the mimotope peptides of phenolic glycolipid-I(PGL-I) of Mycobacterium leprae and bovine serum albumin(BSA).

Abstract translation: 目的：提供麻风分支杆菌的酚性糖脂-I（PGL-I）的模拟表位肽和含有其的麻风病血清诊断试剂盒，由此用价格便宜的PGL-1模拟表位肽代替昂贵的PGL-1。 因此，可以降低麻风病血清诊断的成本。 构成：麻风分支杆菌的酚糖脂-I（PGL-I）的模拟表位肽具有WTLGPYV，WRLGPYV或WTLGPYM的氨基酸序列。 提供了麻风分枝杆菌的酚糖脂-1（PGL-1）和牛血清白蛋白（BSA）的模拟表位肽的缀合物。 用于麻风病血清诊断的试剂盒包含麻风分枝杆菌的酚性糖脂-I（PGL-I）的模拟表位肽或麻风分枝杆菌的酚性糖脂-I（PGL-I）的模拟表位肽与牛血清白蛋白（BSA）的缀合物， 。

公开(公告)号：KR100506118B1

公开(公告)日：2005-08-04

申请号：KR1020030024950

申请日：2003-04-19

Applicant: 학교법인연세대학교

Inventor： 신전수 ,  박인호 ,  최인홍 ,  남문희

IPC: C07K16/12

CPC classification number: C07K16/1217 ,  A61K2039/505 ,  C07K16/42

Abstract: 본 발명은 나이세리아 메닝자이티디스 혈청 그룹 B(
Neisseria meningitidis serogroup B) (NMGB)의 항체인 HmenB3에 대한 항-이디오타입 항체 및 이 항체를 생산하는 하이브리도마(hybridoma)에 관한 것이다. 또한 본 발명은 NMGB 항체 HmenB3에 대한 항-이디오타입 항체 및 약제학적으로 수용 가능한 담체를 포함하는 혈청 그룹 B 수막염균증(meningococci)을 예방 또는 치료할 수 있는 백신 조성물에 관한 것이다.

公开(公告)号：KR1020030083617A

公开(公告)日：2003-10-30

申请号：KR1020030024950

申请日：2003-04-19

Applicant: 학교법인연세대학교

Inventor： 신전수 ,  박인호 ,  최인홍 ,  남문희

IPC: C07K16/12

CPC classification number: C07K16/1217 ,  A61K2039/505 ,  C07K16/42

Abstract: PURPOSE: A vaccine composition for preventing meningococcal disease is provided, thereby preparing an anti-idiotype antibody to NMGB(Neisseria meningitidis serogroup B) having very low antigenicity and consequently improving the immunity to NMGB. CONSTITUTION: An anti-idiotype antibody to HmenB3 as an antibody to NMGB and active fragments thereof are provided, wherein H(heavy) chain of variable region of the anti-idiotype antibody has the putative amino acid sequence of SEQ ID NO: 5 and L(light) chain of variable region of the anti-idiotype antibody has the putative amino acid sequence of SEQ ID NO: 6. A hybridoma producing the anti-idiotype antibody (KCTC 10228BP) is provided. A gene encoding the anti-idiotype antibody is provided, wherein the nucleotide sequence encoding the H chain of the variable region is represented by SEQ ID NO: 7, and the nucleotide sequence encoding the L chain of the variable region is represented by SEQ ID NO: 8. The vaccine composition for preventing meningococcal disease comprises the anti-idiotype antibody or active fragments thereof and pharmaceutically acceptable carriers.

Abstract translation: 目的：提供一种用于预防脑膜炎球菌病的疫苗组合物，从而制备具有非常低抗原性的NMGB（脑膜炎奈瑟氏球菌血清群B）的抗独特型抗体，从而提高对NMGB的免疫力。 构成：提供了作为NMGB抗体的HmenB3的抗独特型抗体及其活性片段，其中抗独特型抗体的可变区的H（重链）具有SEQ ID NO：5和L的推定的氨基酸序列 抗独特型抗体的可变区的（轻链）具有SEQ ID NO：6的推定的氨基酸序列。提供了产生抗独特型抗体（KCTC 10228BP）的杂交瘤。 提供编码抗独特型抗体的基因，其中编码可变区的H链的核苷酸序列由SEQ ID NO：7表示，编码可变区的L链的核苷酸序列由SEQ ID NO 8.用于预防脑膜炎球菌疾病的疫苗组合物包含抗独特型抗体或其活性片段和药学上可接受的载体。

公开(公告)号：KR1020040020246A

公开(公告)日：2004-03-09

申请号：KR1020020051780

申请日：2002-08-30

Applicant: 학교법인연세대학교

Inventor： 신전수 ,  윤주호 ,  조상래

IPC: C07K7/06

CPC classification number: C07K7/06 ,  C07K14/765 ,  C07K2319/00 ,  G01N33/6896

Abstract: PURPOSE: Mimotope peptides of phenolic glycolipid-I(PGL-I) of Mycobacterium leprae and a kit for serodiagnosis of leprosy containing the same are provided, thereby substituting expensive PGL-I with the cheap mimotope peptide of PGL-I. Therefore, the cost for serodiagnosis of leprosy can be decreased. CONSTITUTION: Mimotope peptides of phenolic glycolipid-I(PGL-I) of Mycobacterium leprae have the amino acid sequence of WTLGPYV, WRLGPYV or WTLGPYM. A conjugate of the mimotope peptides of phenolic glycolipid-I(PGL-I) of Mycobacterium leprae and bovine serum albumin(BSA) is provided. A kit for serodiagnosis of leprosy contains the mimotope peptides of phenolic glycolipid-I(PGL-I) of Mycobacterium leprae or the conjugate of the mimotope peptides of phenolic glycolipid-I(PGL-I) of Mycobacterium leprae and bovine serum albumin(BSA).

Abstract translation: 目的：提供麻风分枝杆菌的酚糖脂I（PGL-I）的模拟表位肽和含有此类麻风病血清学诊断的试剂盒，从而用廉价的PGL-1模拟表位肽代替昂贵的PGL-1。 因此，可以降低麻风病血清学诊断成本。 构成：麻风分枝杆菌的酚糖脂I（PGL-1）的模拟表位肽具有WTLGPYV，WRLGPYV或WTLGPYM的氨基酸序列。 提供了麻风分枝杆菌的酚糖脂I（PGL-1）和牛血清白蛋白（BSA）的模拟表位肽的缀合物。 用于麻风病血清诊断的试剂盒含有麻风分枝杆菌的酚糖脂I（PGL-1）的模拟表位肽，或分枝杆菌和牛血清白蛋白（BSA）的酚糖脂I（PGL-1）的模拟表位肽的缀合物， 。