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公开(公告)号：KR1020020076562A
公开(公告)日：2002-10-11
申请号：KR1020010016517
申请日：2001-03-29
Applicant: 학교법인연세대학교
IPC: C12N15/55
CPC classification number: C12N9/16 , C12Y301/03048
Abstract: PURPOSE: A dual specific phosphatase with anticancer activity is provided. It specifically inhibits ERK(extra-cellular regulated kinase) activity and proceeding of from G1 to S, therefore, it is useful for the treatment of cancer associated with MAP-kinase(mitogen-activated protein kinase) pathway. CONSTITUTION: The drosophila MAPK phosphatase gene specifically inhibiting the ERK has the nucleotide sequence of SEQ ID NO: 1, in which the ERK is derived from mammals or Drosophila. An expression vector containing the drosophila MAPK phosphatase gene is selected from the group consisting of pOT2-DMKP-3, pMT/V5-DMKP-3, pPacPL-DMKP-3, pcDNA3.1-DMKP-3 and pB42AD-DMKP-3. The drosophila MAPK phosphatase has the amino acid sequence of SEQ ID NO: 2.
Abstract translation: 目的：提供具有抗癌活性的双重特异性磷酸酶。 它特异性地抑制ERK（细胞外调节激酶）活性和从G1到S的进行，因此，它可用于治疗与MAP-激酶（丝裂原活化蛋白激酶）途径相关的癌症。 构成：特异性抑制ERK的果蝇MAPK磷酸酶基因具有SEQ ID NO：1的核苷酸序列，其中ERK衍生自哺乳动物或果蝇。 含有果蝇MAPK磷酸酶基因的表达载体选自pOT2-DMKP-3，pMT / V5-DMKP-3，pPacPL-DMKP-3，pcDNA3.1-DMKP-3和pB42AD-DMKP-3。 果蝇MAPK磷酸酶具有SEQ ID NO：2的氨基酸序列。
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公开(公告)号：KR1020050066216A
公开(公告)日：2005-06-30
申请号：KR1020030097473
申请日：2003-12-26
Applicant: 학교법인연세대학교
IPC: C12N15/54
CPC classification number: C12N9/1205 , C12Q1/66 , C12Y207/01002 , G01N33/5044 , G01N33/573 , G01N2333/90241
Abstract: 본 발명은 간에서 발현되는 글루코키나아제(L-GK)의 전사조절부위에서 퍼옥시좀 증식체 활성화된 수용체-γ(peroxisomal proliferator activated receptor-γ, PPARγ)가 결합하는 퍼옥시좀 증식 반응 요소(peroxisomal proliferator response element, PPRE)의 유전자 서열에 관한 것이다.
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Patent Agency Ranking
公开(公告)号：KR100410784B1
公开(公告)日：2003-12-31
申请号：KR1020010016517
申请日：2001-03-29
Applicant: 학교법인연세대학교
IPC: C12N15/55
Abstract: PURPOSE: A dual specific phosphatase with anticancer activity is provided. It specifically inhibits ERK(extra-cellular regulated kinase) activity and proceeding of from G1 to S, therefore, it is useful for the treatment of cancer associated with MAP-kinase(mitogen-activated protein kinase) pathway. CONSTITUTION: The drosophila MAPK phosphatase gene specifically inhibiting the ERK has the nucleotide sequence of SEQ ID NO: 1, in which the ERK is derived from mammals or Drosophila. An expression vector containing the drosophila MAPK phosphatase gene is selected from the group consisting of pOT2-DMKP-3, pMT/V5-DMKP-3, pPacPL-DMKP-3, pcDNA3.1-DMKP-3 and pB42AD-DMKP-3. The drosophila MAPK phosphatase has the amino acid sequence of SEQ ID NO: 2.
Abstract translation: 目的：提供具有抗癌活性的双特异性磷酸酶。 它特异性地抑制ERK（细胞外调节激酶）活性和从G1到S的进程，因此它可用于治疗与MAP-激酶（促分裂原活化蛋白激酶）途径相关的癌症。 构成：特异性抑制ERK的果蝇MAPK磷酸酶基因具有SEQ ID NO：1的核苷酸序列，其中ERK来源于哺乳动物或果蝇。 含有果蝇MAPK磷酸酶基因的表达载体选自pOT2-DMKP-3，pMT / V5-DMKP-3，pPacPL-DMKP-3，pcDNA3.1-DMKP-3和pB42AD-DMKP-3。 果蝇MAPK磷酸酶具有SEQ ID NO：2的氨基酸序列。
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公开(公告)号：KR1020050063081A
公开(公告)日：2005-06-28
申请号：KR1020030094144
申请日：2003-12-19
Applicant: 학교법인연세대학교
IPC: C12N15/54
CPC classification number: C12N9/1205 , C12Q1/66 , C12Y207/01002 , G01N33/5044 , G01N33/573
Abstract: 본 발명은 간에서 발현되는 글루코키나아제(L-GK)의 전사조절부위에서 스테롤조절인자 결합단백질(SREBP)이 결합하는 스테롤조절인자(SRE)의 유전자 서열에 관한 것이다.
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公开(公告)号：KR100523849B1
公开(公告)日：2005-10-25
申请号：KR1020030097473
申请日：2003-12-26
Applicant: 학교법인연세대학교
IPC: C12N15/54
Abstract: 본 발명은 간에서 발현되는 글루코키나아제(L-GK)의 전사조절부위에서 퍼옥시좀 증식체 활성화된 수용체-γ(peroxisomal proliferator activated receptor-γ, PPARγ)가 결합하는 퍼옥시좀 증식 반응 요소(peroxisomal proliferator response element, PPRE)의 유전자 서열에 관한 것이다.
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公开(公告)号：KR1020050063080A
公开(公告)日：2005-06-28
申请号：KR1020030094143
申请日：2003-12-19
Applicant: 학교법인연세대학교
IPC: C12N15/12
CPC classification number: C07K14/4702 , C12N15/86
Abstract: 본 발명은 간에서 발현되어 포도당 항상성 유지에 관여하는 포도당 운반체 타입 2(GLUT2)의 전사조절부위에서 스테롤조절인자 결합단백질이 결합하는 스테롤조절인자의 유전자 서열에 관한 것이다.
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