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公开(公告)号：KR100451154B1
公开(公告)日：2004-10-02
申请号：KR1020010044513
申请日：2001-07-24
Applicant: 엘지전자 주식회사 , 학교법인 포항공과대학교
IPC: G01N1/00
CPC classification number: F04B43/1223 , B01L3/5025 , B01L3/502707 , B01L3/50273 , B01L3/505 , B01L2300/028 , B01L2300/0816 , B01L2300/0867 , B01L2400/0481 , F04B43/043 , G01N30/32 , G01N2030/326
Abstract: Minute or infinitesimal amounts of fluid can be accurately delivered through microchannels formed in an elastic polymeric substrate. External (mechanical) force is applied on the substrate to progressively squeeze the microchannel along its length to push or pull the fluid through the microchannel. Fluids can be delivered at a constant rate and amount regardless of the kind of the fluid since fluid delivery is not affected by the physical properties of the fluid. The delivery rate of the fluid is determined in the ranges between femtoliters/sec and milliliters/sec by the size of the microchannel and the area of the substrate being pressed by the applied external (mechanical) force. Such techniques of fluid delivery can be applied to various fields including lab-on-a-chip technology, monitoring of chemical and biological processing, portable analyzing instruments, fine chemistry, clinical diagnosis and development of new medicines.
Abstract translation: 微小或微量的流体可以通过在弹性聚合物基材中形成的微通道准确地输送。 外部（机械）力施加在基底上以逐渐挤压沿其长度的微通道以推动或拉动流体通过微通道。 由于流体输送不受流体物理特性的影响，因此流体可以以恒定速率和量输送，而与流体种类无关。 通过微通道的大小和被施加的外部（机械）力压缩的基板的面积，确定流体的传送速率在飞升/秒和毫升/秒之间的范围内。 这种流体输送技术可应用于各种领域，包括实验室芯片技术，化学和生物处理的监测，便携式分析仪器，精细化学，临床诊断和新药开发。 ＆lt;图像＆GT;
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公开(公告)号：KR100455661B1
公开(公告)日：2004-11-12
申请号：KR1020010043803
申请日：2001-07-20
Applicant: 학교법인 포항공과대학교
IPC: C12Q1/68
CPC classification number: B01L3/5027 , B01L2200/10 , G01N21/64 , G01N30/6095 , G01N2021/6476
Abstract: PURPOSE: A lap on a chip system for analysis of amine compounds is provided, thereby successively carrying out reaction and separation, and producing the lap on a chip system simply. CONSTITUTION: The lap on a chip system for analysis of amine compounds comprises a reactor for fluorescence induction of amine compounds and a separation channel for separation of each amine compound, wherein the reactor and the separation channel are sequentially connected on a board; the inner volume of the reactor ranges from 0.01 picoliter(pL) to 10 milliliter(mL); the separation channel has the width ranging from 10 nm to 10 cm, the height of 10 nm to 1 cm, and the length of 10 nm to 100 cm; the amine compound is at least one compound selected from the group consisting of alkylamine, aromatic amine, amino acid, biogenic amine and ammonia; and the lap on a chip is made of glass, crystal, melted silica or plastic. The lap on a chip system comprises a sample vessel(1), a reagent vessel(2), a reactor(3), a buffer solution vessel(4), a reacted solution discharging vessel(5), a buffer solution discharging vessel(6) and a separation channel(7).
Abstract translation: 目的：提供一种用于分析胺化合物的芯片系统，从而连续地进行反应和分离，并简单地生产芯片系统上的棉卷。 构成：用于分析胺化合物的芯片系统上的棉卷包括用于荧光诱导胺化合物的反应器和用于分离每种胺化合物的分离通道，其中反应器和分离通道依次连接在板上; 反应器的内部容积为0.01皮升（pL）至10毫升（mL）; 分离通道的宽度范围从10nm到10cm，高度为10nm到1cm，长度为10nm到100cm; 胺化合物是选自烷基胺，芳香胺，氨基酸，生物胺和氨中的至少一种化合物; 芯片上的搭接片由玻璃，水晶，熔化的硅胶或塑料制成。 芯片搭接系统包括样本容器1，试剂容器2，反应器3，缓冲溶液容器4，反应溶液排出容器5，缓冲溶液排出容器5， 6）和分离通道（7）。
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公开(公告)号：KR1020030009858A
公开(公告)日：2003-02-05
申请号：KR1020010044514
申请日：2001-07-24
Applicant: 엘지전자 주식회사 , 학교법인 포항공과대학교
IPC: G01N1/00
CPC classification number: G01N30/32 , F04B43/043 , F04B43/12 , G01N2030/326 , Y10T436/2575
Abstract: PURPOSE: A method for delivering a fluid in a substrate made of an elastic material and a device thereof are provided to effectively deliver a fluid regardless of the kind of the fluid in the amount range from pl to ml by using a simply structured device. CONSTITUTION: In a method for delivering a fluid in a substrate made of an elastic material, a mechanical pressure is periodically applied to a surface of a substrate, made of an elastic polymer having micro channels inside, from the outside of the substrate by using a rotator, so that a fluid in the micro channels is delivered, wherein the rotator is a wheel in the shape of saw-tooth, and the pressure and the position applied with the pressure with respect to the micro channels is periodically changed over a range of the entire diameter of the rotator.
Abstract translation: 目的：提供一种用于输送由弹性材料制成的基材中的流体的方法及其装置，其通过使用简单的结构化装置来有效地输送流体的种类，范围从P1到ml。 构成：在用于在由弹性材料制成的衬底中输送流体的方法中，通过使用一种机械压力，将机械压力周期性地施加到由衬底外部具有微通道的弹性聚合物制成的衬底的表面上 旋转器，使得微通道中的流体被输送，其中旋转器是具有锯齿形状的轮，并且施加有相对于微通道的压力的压力和位置周期性地在 旋转体的整个直径。
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公开(公告)号：KR100681943B1
公开(公告)日：2007-02-12
申请号：KR1020050074202
申请日：2005-08-12
Applicant: 학교법인 포항공과대학교 , 포항공과대학교 산학협력단
IPC: C12Q1/68
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公开(公告)号：KR100593263B1
公开(公告)日：2006-06-26
申请号：KR1020040006740
申请日：2004-02-02
Applicant: 학교법인 포항공과대학교
IPC: C12Q1/68
Abstract: 본 발명은 시간에 따른 반복적인 온도조절이 필요한 반응에 응용하기 위한 연속 흐름상 반응 장치에 관한 것으로, 서로 다른 온도로 조절되는 둘 이상의 고체상 가열 블록, 및 유체 주입구인 제1 말단과 유체 배출구인 제2 말단을 가지며 제1 말단으로부터 제2 말단으로의 연속적인 유체의 흐름을 허용하는 모세관을 포함하고, 상기 모세관이 서로 다른 온도로 조절되는 가열 블록을 순차적으로 또는 반복적으로 접촉하는 것을 특징으로 하는 고성능 연속 흐름상 반응 장치를 제공한다.
본 발명에 따른 연속 흐름상 반응 장치는 연속적으로 흐르는 유체를 반응시키는데 유용하게 이용될 수 있으며, 특히 중합효소 연쇄반응에 유용하게 이용될 수 있다.-
Patent Agency Ranking
公开(公告)号：KR100421359B1
公开(公告)日：2004-03-06
申请号：KR1020010044514
申请日：2001-07-24
Applicant: 엘지전자 주식회사 , 학교법인 포항공과대학교
IPC: G01N1/00
CPC classification number: G01N30/32 , F04B43/043 , F04B43/12 , G01N2030/326 , Y10T436/2575
Abstract: Various kinds of fluid can be handled and delivered accurately in infinitesimal amounts through microchannels formed in an elastic polymeric substrate by periodically squeezing selective portions of the microchannel using a rotor to apply an external force on the elastic substrate. The delivery rate of the fluid is in the range from pL/sec to mL/sec determined by the rotation speed of the rotor which presses the microchannels and the dimensions of the microchannel. Regardless of physical properties of the fluid to be delivered, various kinds of fluids can be accurately delivered through the microchannels in the desired amount.
Abstract translation: 通过使用转子周期性挤压微通道的选择性部分以在弹性基底上施加外力，可以通过在弹性聚合物基底中形成的微通道精确地处理和输送各种类型的流体，其量极微量。 流体的输送速率在由按压微通道的转子的转速和微通道的尺寸确定的pL / sec至mL / sec的范围内。 无论要输送的流体的物理性质如何，可以通过微通道准确地输送所需量的各种流体。 ＆lt;图像＆GT;
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公开(公告)号：KR1020030009857A
公开(公告)日：2003-02-05
申请号：KR1020010044513
申请日：2001-07-24
Applicant: 엘지전자 주식회사 , 학교법인 포항공과대학교
IPC: G01N1/00
CPC classification number: F04B43/1223 , B01L3/5025 , B01L3/502707 , B01L3/50273 , B01L3/505 , B01L2300/028 , B01L2300/0816 , B01L2300/0867 , B01L2400/0481 , F04B43/043 , G01N30/32 , G01N2030/326
Abstract: PURPOSE: A method for handling a fluid in a substrate and a device thereof are provided to transmit a solution quantitatively and precisely by an amount in the range from picoliter to milliliter, wherein the fluid transmission speed is not influenced by the physical characteristics of the fluid so that the fluid is transmitted by a uniform speed. CONSTITUTION: In a method for handling a fluid in a substrate, a solid structure is used for applying a mechanical pressure from the outside to a surface of a substrate formed of an elastic polymer material having micro channels inside, wherein a position to apply the mechanical pressure is changed in the lengthwise direction of the micro channels while the pressure is applied to the substrate, and the pressure is applied to the substrate perpendicularly to the substrate.
Abstract translation: 目的：提供一种用于处理衬底中的流体的方法及其装置，用于以从皮升到毫升的量定量精确地传输溶液，其中流体传播速度不受流体的物理特性的影响 使得流体以均匀的速度传递。 构成：在用于处理衬底中的流体的方法中，使用固体结构将机械压力从外部施加到由具有内部具有微通道的弹性聚合物材料形成的衬底的表面，其中施加机械 在将压力施加到基板上的同时，在微通道的长度方向上的压力变化，并且将压力垂直于基板施加到基板。
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公开(公告)号：KR1020030008340A
公开(公告)日：2003-01-25
申请号：KR1020010043803
申请日：2001-07-20
Applicant: 학교법인 포항공과대학교
IPC: C12Q1/68
CPC classification number: B01L3/5027 , B01L2200/10 , G01N21/64 , G01N30/6095 , G01N2021/6476
Abstract: PURPOSE: A lap on a chip system for analysis of amine compounds is provided, thereby successively carrying out reaction and separation, and producing the lap on a chip system simply. CONSTITUTION: The lap on a chip system for analysis of amine compounds comprises a reactor for fluorescence induction of amine compounds and a separation channel for separation of each amine compound, wherein the reactor and the separation channel are sequentially connected on a board; the inner volume of the reactor ranges from 0.01 picoliter(pL) to 10 milliliter(mL); the separation channel has the width ranging from 10 nm to 10 cm, the height of 10 nm to 1 cm, and the length of 10 nm to 100 cm; the amine compound is at least one compound selected from the group consisting of alkylamine, aromatic amine, amino acid, biogenic amine and ammonia; and the lap on a chip is made of glass, crystal, melted silica or plastic. The lap on a chip system comprises a sample vessel(1), a reagent vessel(2), a reactor(3), a buffer solution vessel(4), a reacted solution discharging vessel(5), a buffer solution discharging vessel(6) and a separation channel(7).
Abstract translation: 目的：提供一种用于分析胺化合物的芯片系统，从而连续进行反应和分离，并简单地在芯片系统上生产搭接。 构成：用于胺化合物分析的芯片系统的搭接包括用于胺化合物的荧光诱导的反应器和用于分离每种胺化合物的分离通道，其中反应器和分离通道依次连接在板上; 反应器的内体积为0.01皮升（pL）至10毫升（mL）; 分离通道的宽度为10nm至10cm，高度为10nm至1cm，长度为10nm至100cm; 胺化合物是选自烷基胺，芳香胺，氨基酸，生物胺和氨中的至少一种化合物; 芯片上的搭接由玻璃，水晶，熔融二氧化硅或塑料制成。 片上系统包括样品容器（1），试剂容器（2），反应器（3），缓冲溶液容器（4），反应溶液排出容器（5），缓冲液排出容器 6）和分离通道（7）。
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公开(公告)号：KR1020050078568A
公开(公告)日：2005-08-05
申请号：KR1020040006740
申请日：2004-02-02
Applicant: 학교법인 포항공과대학교
IPC: C12Q1/68
Abstract: 본 발명은 시간에 따른 반복적인 온도조절이 필요한 반응에 응용하기 위한 연속 흐름상 반응 장치에 관한 것으로, 서로 다른 온도로 조절되는 둘 이상의 고체상 가열 블록, 및 유체 주입구인 제1 말단과 유체 배출구인 제2 말단을 가지며 제1 말단으로부터 제2 말단으로의 연속적인 유체의 흐름을 허용하는 모세관을 포함하고, 상기 모세관이 서로 다른 온도로 조절되는 가열 블록을 순차적으로 또는 반복적으로 접촉하는 것을 특징으로 하는 고성능 연속 흐름상 반응 장치를 제공한다.
본 발명에 따른 연속 흐름상 반응 장치는 연속적으로 흐르는 유체를 반응시키는데 유용하게 이용될 수 있으며, 특히 중합효소 연쇄반응에 유용하게 이용될 수 있다.-
公开(公告)号：KR100413535B1
公开(公告)日：2003-12-31
申请号：KR1020010043106
申请日：2001-07-18
Applicant: 학교법인 포항공과대학교
IPC: G01N21/31
CPC classification number: G01N21/59 , B01L3/502707 , B01L3/502715 , B01L2200/10 , B01L2300/0654 , G01N21/05 , G01N2021/0346 , G01N2021/058
Abstract: A high-efficiency, high-sensitivity absorbance detection system in a lab-on-a-chip is provided. The absorbance detection system includes detection cells having an optical pathlength ten times and/or much longer than the width of a separation channel to improve detection sensitivity, lens structures for collimating light in the detection cells, and slit structures for preventing scattered light from entering detectors. The detection cells, the lens structures, and the slit structures of the absorbance detection system are fabricated and integrated in a lab-on-a-chip. The absorbance detection system exhibits excellent absorption efficiency, detection limit, and linearity, compared to existing absorbance detection systems, and can be applied for the detection of a variety of samples. The absorbance detection system does not need labeling of the samples which saves time and costs. The absorbance detection system can be used effectively in detecting trace compounds with a high sensitivity. The absorbance detection system in a lab-on-a-chip can be used with wider applications to a variety of samples in diverse research fields, such as the drug screening field dealing with simultaneous synthesis and identification of a number of compounds based on combinatorial chemistry, the life sciences field handling trace bioactive materials such as enzymes, proteins, and amino acids, and the environmental research field which needs rapid field monitoring of contaminants.
Abstract translation: 提供了芯片实验室中的高效率，高灵敏度吸光度检测系统。 吸光度检测系统包括检测单元，其具有比分离通道的宽度大十倍和/或长得多的光路长度以改善检测灵敏度，用于准直检测单元中的光的透镜结构以及用于防止散射光进入检测器的狭缝结构 。 检测单元，透镜结构和吸光度检测系统的狭缝结构被制造并集成在芯片实验室中。 与现有的吸光度检测系统相比，吸光度检测系统显示出优异的吸收效率，检测限和线性，并且可用于检测各种样品。 吸光度检测系统不需要标记样品，节省了时间和成本。 吸光度检测系统可以有效地用于高灵敏度检测痕量化合物。 芯片实验室中的吸光度检测系统可广泛用于各种研究领域的各种样品，例如药物筛选领域，涉及基于组合化学的同时合成和许多化合物的鉴定 ，生命科学领域处理痕量生物活性物质，如酶，蛋白质和氨基酸，以及需要对污染物进行快速现场监测的环境研究领域。
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