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公开(公告)号：KR100455661B1
公开(公告)日：2004-11-12
申请号：KR1020010043803
申请日：2001-07-20
Applicant: 학교법인 포항공과대학교
IPC: C12Q1/68
CPC classification number: B01L3/5027 , B01L2200/10 , G01N21/64 , G01N30/6095 , G01N2021/6476
Abstract: PURPOSE: A lap on a chip system for analysis of amine compounds is provided, thereby successively carrying out reaction and separation, and producing the lap on a chip system simply. CONSTITUTION: The lap on a chip system for analysis of amine compounds comprises a reactor for fluorescence induction of amine compounds and a separation channel for separation of each amine compound, wherein the reactor and the separation channel are sequentially connected on a board; the inner volume of the reactor ranges from 0.01 picoliter(pL) to 10 milliliter(mL); the separation channel has the width ranging from 10 nm to 10 cm, the height of 10 nm to 1 cm, and the length of 10 nm to 100 cm; the amine compound is at least one compound selected from the group consisting of alkylamine, aromatic amine, amino acid, biogenic amine and ammonia; and the lap on a chip is made of glass, crystal, melted silica or plastic. The lap on a chip system comprises a sample vessel(1), a reagent vessel(2), a reactor(3), a buffer solution vessel(4), a reacted solution discharging vessel(5), a buffer solution discharging vessel(6) and a separation channel(7).
Abstract translation: 目的：提供一种用于分析胺化合物的芯片系统，从而连续地进行反应和分离，并简单地生产芯片系统上的棉卷。 构成：用于分析胺化合物的芯片系统上的棉卷包括用于荧光诱导胺化合物的反应器和用于分离每种胺化合物的分离通道，其中反应器和分离通道依次连接在板上; 反应器的内部容积为0.01皮升（pL）至10毫升（mL）; 分离通道的宽度范围从10nm到10cm，高度为10nm到1cm，长度为10nm到100cm; 胺化合物是选自烷基胺，芳香胺，氨基酸，生物胺和氨中的至少一种化合物; 芯片上的搭接片由玻璃，水晶，熔化的硅胶或塑料制成。 芯片搭接系统包括样本容器1，试剂容器2，反应器3，缓冲溶液容器4，反应溶液排出容器5，缓冲溶液排出容器5， 6）和分离通道（7）。
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公开(公告)号：KR100442413B1
公开(公告)日：2004-07-30
申请号：KR1020010047123
申请日：2001-08-04
Applicant: 학교법인 포항공과대학교
IPC: B29C65/64
CPC classification number: B81C1/00111 , B29C66/74281 , B29C66/74285 , B81B2201/051 , B81C99/009 , B82Y30/00 , H05K3/20 , H05K3/389 , H05K2203/016 , Y10S428/914 , Y10T428/24802 , Y10T428/24917
Abstract: 본 발명은 유리 또는 실리카 판 상의 금속 미세 패턴을 안정적이고 재현성있게 플라스틱 판 위로 전이시켜 플라스틱 위에 금속 미세 패턴을 형성하는 방법에 관한 것으로, 유리나 기타 증착이 가능한 기판 위에 통상의 방법을 이용하여 금속의 미세 패턴을 형성시킨 다음 필요에 따라서는 자기조립의 특성을 가지고 있는 물질 또는 코로나 방전 등을 이용하여 금속 패턴 표면 또는 패턴이 전이될 플라스틱 표면을 친수성으로 변화시킨 후 이들 두 표면을 직접 접촉시켜 전이를 일으킴을 특징으로 한다.
본 발명의 방법은 기존의 유리판 위에 금속 미세 패턴을 제작하는 방법에 사용되는 기기 이외의 별도의 기기가 필요하지 않으며, 여러 가지의 마이크로패턴도 플라스틱 판 위로 전이시킬 수 있을 뿐 아니라, 기존의 방법으로는 구현하기 어려웠던 플라스틱 내의 미세 패턴이나 전극의 제작을 가능하게 하여 플라스틱 상에서 안정한 금속 전극을 대량으로 생산할 수 있으며, 이를 랩온어칩에 응용할 경우 휴대용 고성능 전기분석 검출 칩의 제작이 가능하다.Abstract translation: 一种方法，包括在无机基材的表面上形成金属微图案，对金属微图案的表面和塑料基材的表面进行表面处理以使其具有化学反应性，并使金属微图案 与塑料基板的表面接触以将金属微图案从无机基板的表面转移到塑料基板的表面，可以使用常规设备容易且简单地进行以产生固定在基板上的一个或多个金属图案 一种塑料材料。
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公开(公告)号：KR1020030009858A
公开(公告)日：2003-02-05
申请号：KR1020010044514
申请日：2001-07-24
Applicant: 엘지전자 주식회사 , 학교법인 포항공과대학교
IPC: G01N1/00
CPC classification number: G01N30/32 , F04B43/043 , F04B43/12 , G01N2030/326 , Y10T436/2575
Abstract: PURPOSE: A method for delivering a fluid in a substrate made of an elastic material and a device thereof are provided to effectively deliver a fluid regardless of the kind of the fluid in the amount range from pl to ml by using a simply structured device. CONSTITUTION: In a method for delivering a fluid in a substrate made of an elastic material, a mechanical pressure is periodically applied to a surface of a substrate, made of an elastic polymer having micro channels inside, from the outside of the substrate by using a rotator, so that a fluid in the micro channels is delivered, wherein the rotator is a wheel in the shape of saw-tooth, and the pressure and the position applied with the pressure with respect to the micro channels is periodically changed over a range of the entire diameter of the rotator.
Abstract translation: 目的：提供一种用于输送由弹性材料制成的基材中的流体的方法及其装置，其通过使用简单的结构化装置来有效地输送流体的种类，范围从P1到ml。 构成：在用于在由弹性材料制成的衬底中输送流体的方法中，通过使用一种机械压力，将机械压力周期性地施加到由衬底外部具有微通道的弹性聚合物制成的衬底的表面上 旋转器，使得微通道中的流体被输送，其中旋转器是具有锯齿形状的轮，并且施加有相对于微通道的压力的压力和位置周期性地在 旋转体的整个直径。
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公开(公告)号：KR1020030008455A
公开(公告)日：2003-01-29
申请号：KR1020010043107
申请日：2001-07-18
Applicant: 학교법인 포항공과대학교
IPC: G01N1/10
CPC classification number: H01J49/04 , G01N1/34 , G01N2001/4016 , G01N2030/009 , Y10T436/117497 , Y10T436/118339 , Y10T436/24 , Y10T436/25125 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
Abstract: PURPOSE: A sample pretreatment apparatus for mass spectrometry is provided to remove a salt material having a low molecular mass from a specimen having a high molecular mass in a rapid and efficient manner. CONSTITUTION: A sample pretreatment apparatus comprises a specimen injection port(12); a treatment solution injection port(14); a channel(10) having an end connected to the specimen injection port and the treatment solution injection port, and formed within a substrate having a laminar flow for the specimen injected from the specimen injection port and a laminar flow for the treatment solution injected from the treatment solution injection port; a low-molecular material outlet port(18) connected to the other end of the channel, opposite to the treatment solution injection port, and which discharges a low-molecular material from the specimen when the specimen flows along the channel; and a polymer material outlet port(16) connected to the other end of the channel, opposite to the specimen injection port, and which discharges a polymer material from the specimen when the specimen flows along the channel.
Abstract translation: 目的：提供一种用于质谱的样品预处理装置，以快速有效的方式从具有高分子量的样品中除去具有低分子量的盐。 构成：样品预处理装置包括试样注入口（12）; 处理溶液注入口（14）; 具有与试样注入口和处理液注入口连接的端部的通道（10），形成在从试样注入口注入的试样的层流的基板和从所述试样注入口注入的处理液的层流 处理溶液注入口; 连接到通道另一端的低分子材料出口（18），与处理液注入口相对，并且当试样沿着通道流动时，从样品中排出低分子材料; 以及与样品注入口相对的通道的另一端连接的聚合物材料出口（16），当样品沿着通道流动时，从样品中排出聚合物材料。
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公开(公告)号：KR1020030008339A
公开(公告)日：2003-01-25
申请号：KR1020010043802
申请日：2001-07-20
Applicant: 학교법인 포항공과대학교
IPC: C12Q1/68
Abstract: PURPOSE: A lap on a chip system in which the chips are connected each other by numerous capillaries are provided, therefore the costs and time for producing the lap on a chip system can be decreased, and its applications can be easily modified by change of kinds of capillaries. CONSTITUTION: The lap on a chip system contains various types of lap on a chip modules, wherein each module carries out each distinct function including reaction with samples, separation and detection and the chips are connected each other by numerous capillaries; the capillaries are selected from the hollow type capillary, small sized material-packing capillary, gel type polymer-packing capillary and inner surface-treated capillary; the gel is agarose, polyacrylamide or cellulose; and the capillary is made of crystal, melted silica, glass or polymer. The lap on a chip module is produced by using two lower plates(1) having channels, plastic pipes(2), a capillary(3), covering plates(4) and pipette tips(5).
Abstract translation: 目的：提供一种芯片系统中的芯片通过多个毛细管连接在一起的芯片，因此可以减少芯片系统上生产搭接的成本和时间，并且可以通过更改类型轻松修改应用程序 的毛细血管 构成：片上系统包含片上模块各种类型的搭接，其中每个模块执行每个不同的功能，包括与样品的反应，分离和检测，并且芯片由多个毛细管相互连接; 毛细管选自中空型毛细管，小尺寸材料包装毛细管，凝胶型聚合物包装毛细管和内表面处理毛细管; 凝胶是琼脂糖，聚丙烯酰胺或纤维素; 并且毛细管由晶体，熔融二氧化硅，玻璃或聚合物制成。 通过使用具有通道的两个下板（1），塑料管（2），毛细管（3），盖板（4）和移液管尖端（5）来制造芯片模块上的搭接。
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Patent Agency Ranking
公开(公告)号：KR100681943B1
公开(公告)日：2007-02-12
申请号：KR1020050074202
申请日：2005-08-12
Applicant: 학교법인 포항공과대학교 , 포항공과대학교 산학협력단
IPC: C12Q1/68
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公开(公告)号：KR100593263B1
公开(公告)日：2006-06-26
申请号：KR1020040006740
申请日：2004-02-02
Applicant: 학교법인 포항공과대학교
IPC: C12Q1/68
Abstract: 본 발명은 시간에 따른 반복적인 온도조절이 필요한 반응에 응용하기 위한 연속 흐름상 반응 장치에 관한 것으로, 서로 다른 온도로 조절되는 둘 이상의 고체상 가열 블록, 및 유체 주입구인 제1 말단과 유체 배출구인 제2 말단을 가지며 제1 말단으로부터 제2 말단으로의 연속적인 유체의 흐름을 허용하는 모세관을 포함하고, 상기 모세관이 서로 다른 온도로 조절되는 가열 블록을 순차적으로 또는 반복적으로 접촉하는 것을 특징으로 하는 고성능 연속 흐름상 반응 장치를 제공한다.
본 발명에 따른 연속 흐름상 반응 장치는 연속적으로 흐르는 유체를 반응시키는데 유용하게 이용될 수 있으며, 특히 중합효소 연쇄반응에 유용하게 이용될 수 있다.-
公开(公告)号：KR100421359B1
公开(公告)日：2004-03-06
申请号：KR1020010044514
申请日：2001-07-24
Applicant: 엘지전자 주식회사 , 학교법인 포항공과대학교
IPC: G01N1/00
CPC classification number: G01N30/32 , F04B43/043 , F04B43/12 , G01N2030/326 , Y10T436/2575
Abstract: Various kinds of fluid can be handled and delivered accurately in infinitesimal amounts through microchannels formed in an elastic polymeric substrate by periodically squeezing selective portions of the microchannel using a rotor to apply an external force on the elastic substrate. The delivery rate of the fluid is in the range from pL/sec to mL/sec determined by the rotation speed of the rotor which presses the microchannels and the dimensions of the microchannel. Regardless of physical properties of the fluid to be delivered, various kinds of fluids can be accurately delivered through the microchannels in the desired amount.
Abstract translation: 通过使用转子周期性挤压微通道的选择性部分以在弹性基底上施加外力，可以通过在弹性聚合物基底中形成的微通道精确地处理和输送各种类型的流体，其量极微量。 流体的输送速率在由按压微通道的转子的转速和微通道的尺寸确定的pL / sec至mL / sec的范围内。 无论要输送的流体的物理性质如何，可以通过微通道准确地输送所需量的各种流体。 ＆lt;图像＆GT;
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公开(公告)号：KR1020030010504A
公开(公告)日：2003-02-05
申请号：KR1020020043389
申请日：2002-07-23
Applicant: 주식회사 포스코 , 학교법인 포항공과대학교
IPC: C12Q1/68
Abstract: PURPOSE: Provided is a method for electrochemically detecting nucleic acid hybridization on a DNA chip or a biochip, thereby simply detecting nucleic acid hybridization with low cost. CONSTITUTION: The detection method of nucleic acid hybridization comprises the steps of: preparing an oligo plate by fixing a capture probe to an electrode; preparing a hybridized nucleic acid by the reaction of the capture probe with a target probe; the reaction of a nucleic acid binding material with the hybridized nuclei acid or the capture probe; and determining the hybridization by electrochemically measuring an electric current of the electrode in an electrolyte.
Abstract translation: 目的：提供一种在DNA芯片或生物芯片上电化学检测核酸杂交的方法，从而简单地以低成本检测核酸杂交。 构成：核酸杂交的检测方法包括以下步骤：通过将捕获探针固定到电极来制备寡聚体平板; 通过捕获探针与目标探针的反应制备杂交核酸; 核酸结合材料与杂交核酸或捕获探针的反应; 以及通过电化学测量电解质中电极的电流来确定杂交。
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公开(公告)号：KR1020030009857A
公开(公告)日：2003-02-05
申请号：KR1020010044513
申请日：2001-07-24
Applicant: 엘지전자 주식회사 , 학교법인 포항공과대학교
IPC: G01N1/00
CPC classification number: F04B43/1223 , B01L3/5025 , B01L3/502707 , B01L3/50273 , B01L3/505 , B01L2300/028 , B01L2300/0816 , B01L2300/0867 , B01L2400/0481 , F04B43/043 , G01N30/32 , G01N2030/326
Abstract: PURPOSE: A method for handling a fluid in a substrate and a device thereof are provided to transmit a solution quantitatively and precisely by an amount in the range from picoliter to milliliter, wherein the fluid transmission speed is not influenced by the physical characteristics of the fluid so that the fluid is transmitted by a uniform speed. CONSTITUTION: In a method for handling a fluid in a substrate, a solid structure is used for applying a mechanical pressure from the outside to a surface of a substrate formed of an elastic polymer material having micro channels inside, wherein a position to apply the mechanical pressure is changed in the lengthwise direction of the micro channels while the pressure is applied to the substrate, and the pressure is applied to the substrate perpendicularly to the substrate.
Abstract translation: 目的：提供一种用于处理衬底中的流体的方法及其装置，用于以从皮升到毫升的量定量精确地传输溶液，其中流体传播速度不受流体的物理特性的影响 使得流体以均匀的速度传递。 构成：在用于处理衬底中的流体的方法中，使用固体结构将机械压力从外部施加到由具有内部具有微通道的弹性聚合物材料形成的衬底的表面，其中施加机械 在将压力施加到基板上的同时，在微通道的长度方向上的压力变化，并且将压力垂直于基板施加到基板。
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