公开(公告)号：KR100321312B1

公开(公告)日：2002-03-18

申请号：KR1019990014355

申请日：1999-04-22

Applicant: 한국과학기술연구원

Inventor： 이정준 ,  이정형 ,  김항섭 ,  홍영수 ,  구태현

IPC: A61K31/34

Abstract: 본발명은태산목 (L.)의잎에서추출한세스퀴테르펜락톤 (sesquiterpene lactone) 화합물로서염증질환및 면역질환치료제로이용될수 있는, 화학식 1의구조를갖는코스투놀라이드 (costunolide)에관한것으로, 상기화합물들은인체의면역체계를조절하는중요한인자인산화질소 (nitric oxide, NO)나종양괴사인자-알파 (TNF-α)의생성을억제하고, 염증매개인자의발현에중요한전사인자인 NF-κB의활성화를억제함으로써, 산화질소나종양괴사인자-알파의과잉생성또는 NF-κB의활성화에의해야기되는염증관련질환및 면역질환의효과적인치료제로이용될수 있다. 코스투놀라이드

公开(公告)号：KR1020000066932A

公开(公告)日：2000-11-15

申请号：KR1019990014355

申请日：1999-04-22

Applicant: 한국과학기술연구원

Inventor： 이정준 ,  이정형 ,  김항섭 ,  홍영수 ,  구태현

IPC: A61K31/34

Abstract: PURPOSE: A sesquiterpene lactone compound, costunolide is provided, which inhibits production of nitric oxide(NO) or tumor necrosis factor-alpha(TNF-alpha)(they are important factor for controling of human immune system); and inhibits activity of NF-kappaB, the important transcription factor in representation of inflammation-mediate-factor; so which can be used as a medicine for inflammation-related disease and immune-disease. CONSTITUTION: The costunolide is gained from Magnolia grandiflora L. by methanol-extracting, which can be administrated by oral or parenteral, and can be used as a form of common pharmaceutical preparation, e.g., tablets, pills, granules, powders, capsules, suspension, liquid preparation for oral, emulsion, syrup, sterilized solution for injection, suppositories. An effective dosage of sesquiterpene lactone compound, the costunolide is 5-50mg/kg, desirably 5-20mg/kg, which can be administrated 1-3times per day.

Abstract translation: 目的：提供倍半萜内酯化合物，其可以抑制一氧化氮（NO）或肿瘤坏死因子-α（TNF-α）的产生（它们是控制人体免疫系统的重要因素）; 并抑制NF-κB的活性，NF-κB是代表炎症介导因子的重要转录因子; 因此可用作炎症相关疾病和免疫疾病的药物。 成分法：通过甲醇提取法，从大兰木兰获得木贼多糖，其可以通过口服或肠胃外给药，并且可以用作常见药物制剂的形式，例如片剂，丸剂，颗粒剂，粉剂，胶囊剂，悬浮液 口服液剂，乳剂，糖浆，注射用灭菌溶液，栓剂。 有效剂量的倍半萜内酯化合物，肋骨瓜内酯为5-50mg / kg，理想的为5-20mg / kg，可以每天施用1-3次。