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    생물 직교성 무동 클릭 화학을 통한 나노입자의 생체내 표적화 방법
    2.
    发明公开
    생물 직교성 무동 클릭 화학을 통한 나노입자의 생체내 표적화 방법 有权
    通过生物元素无铜点击化学方法对纳米颗粒进行生物分析

    公开(公告)号：KR1020130106654A

    公开(公告)日：2013-09-30

    申请号：KR1020120028370

    申请日：2012-03-20

    Applicant: 한국과학기술연구원

    Inventor： 김광명 ,  권익찬 ,  최귀원 ,  구희범 ,  이상민 ,  윤인찬

    IPC: A61K9/16 ,  A61K47/48 ,  A61K31/70 ,  A61K31/395

    CPC classification number: A61K47/26 ,  A61K47/34 ,  A61K47/549 ,  A61K47/555 ,  A61K47/6911 ,  A61K49/0032 ,  A61K49/0052 ,  A61K9/16 ,  A61K31/395 ,  A61K31/70 ,  A61K47/50

    Abstract: PURPOSE: A method for in vivo targeting of nanoparticles by bioorthogonal copper-free click chemistry is provided to control the in vivo distribution of nanoparticles and to remarkably increase the accumulation in vivo of the nanoparticle in a target part. CONSTITUTION: A method for in vivo targeting of nanoparticles comprises a step of putting in the precursor which can control metabolism in vivo and has a first bioorthogonal functional group; and a step of putting a nanoparticle which is attached with a second bioorthogonal functional group bioorthogonally reactable with the first bioorthogonal functional group. The metabolism control is a sugar chain control. The precursor is a compound selected from chemical formulas 1 to 3.

    Abstract translation: 目的：提供通过生物正交无铜点击化学体内靶向纳米颗粒的方法，以控制纳米颗粒的体内分布，并显着增加目标部位纳米颗粒的体内积累。 构成：纳米颗粒的体内靶向的方法包括放入可控制体内代谢并具有第一生物正交官能团的前体的步骤; 以及将与第一生物正交官能团生物同向生物反应的第二生物正交官能团附着的纳米粒子的步骤。 代谢控制是糖链控制。 前体是选自化学式1至3的化合物。

    종양 표적화 가스 발생 나노입자, 그 제조방법 및 이를 이용한 종양 표적화 약물 전달 나노입자
    3.
    发明公开
    종양 표적화 가스 발생 나노입자, 그 제조방법 및 이를 이용한 종양 표적화 약물 전달 나노입자 有权
    肿瘤靶向气体产生纳米颗粒，其制备方法和用于药物递送的肿瘤靶向纳米颗粒

    公开(公告)号：KR1020130134810A

    公开(公告)日：2013-12-10

    申请号：KR1020120058600

    申请日：2012-05-31

    Applicant: 한국과학기술연구원

    Inventor： 권익찬 ,  김광명 ,  최귀원 ,  구희범 ,  민현수 ,  윤인찬

    IPC: A61K9/16 ,  A61K9/14 ,  A61K51/02 ,  A61P35/00

    CPC classification number: A61K9/5146 ,  A61K9/0004 ,  A61K9/0009 ,  A61K9/0019 ,  A61K9/5153 ,  A61K41/0028 ,  A61K47/6925 ,  A61K49/0032 ,  A61K49/0054 ,  A61K49/0093 ,  A61K49/222 ,  A61K49/225

    Abstract: The present invention relates to tumor-targeting gas-generating nanoparticles, a method for preparing the same, and tumor-targeting drug delivery nanoparticles using the same and, more specifically, to tumor-targeting gas-generating nanoparticles including a carbonate polymer core and an amphiphilic outer cover, a method for preparing the same, and tumor-targeting drug delivery nanoparticles using the same. The tumor-targeting gas-generating nanoparticles according to the present invention can be usefully used as an ultrasonic imaging agent since the nanoparticles generate a strong ultrasonic signal after being aggregated and accumulated in the tumor tissue and shows improved performance in tumor specific drug delivery since the nanoparticle has improved penetration and bodily fluid effects and improved cell transmission ability, and the like. [Reference numerals] (AA) Carbonate polymer core;(BB) Amphiphilic outer cover;(CC) Diffuse H_2O;(DD) Hydrolysis;(EE) Generate CO_2;(FF) Ultrasonic signal generation;(GG) Tumor accumulation;(HH) Bonding

    Abstract translation: 本发明涉及肿瘤靶向产生气体的纳米颗粒，其制备方法和使用其的肿瘤靶向药物递送纳米粒子，更具体地，涉及包含碳酸酯聚合物核心和 两亲性外覆盖物，其制备方法和使用其的肿瘤靶向药物递送纳米粒子。 根据本发明的肿瘤靶向产生气体的纳米颗粒可以有效地用作超声显像剂，因为纳米颗粒在聚集并积累在肿瘤组织中后产生强烈的超声信号，并且在肿瘤特异性药物递送中表现出改进的性能，因为 纳米颗粒具有改善的渗透和体液效应和改善的细胞传递能力等。 （AA）碳酸酯聚合物芯;（BB）两亲性外盖;（CC）扩散H_2O;（DD）水解;（EE）产生CO_2;（FF）超声信号产生;（GG）肿瘤积聚;（HH ）粘合

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