티로신 키나아제 저해 화합물, 이의 이성질체 또는 이의 약학적으로 허용가능한 염 및 이를 포함하는 약학적 조성물
    5.
    发明公开
    티로신 키나아제 저해 화합물, 이의 이성질체 또는 이의 약학적으로 허용가능한 염 및 이를 포함하는 약학적 조성물 有权
    酪氨酸激酶抑制化合物,其异构体或其药物可接受的盐,以及包含其的药物组合物

    公开(公告)号:KR1020100060300A

    公开(公告)日:2010-06-07

    申请号:KR1020080118850

    申请日:2008-11-27

    CPC classification number: C07D513/04

    Abstract: PURPOSE: A tyrosine kinase compound is provided to suppress the tyrosine kinase activation of DDR1 and DDR2 and to prevent or treat cancer, arteriosclerosis, rheumatoid arthritis, and osteoarthritis. CONSTITUTION: A tyrosine kinase suppression compound is denoted by chemical formula 1. A pharmaceutical composition for anti-cancer contains a compound of chemical formula 1, isomer, or a pharmaceutically acceptable salt thereof as an active ingredient. The pharmaceutically acceptable salt is hydrochloride or trifluoroacetic acid salt. A pharmaceutical composition for preventing or treating rheumatism or osteoarthritis contains the compound of chemical formula 1, the isomer, and the salt as active ingredients.

    Abstract translation: 目的:提供酪氨酸激酶化合物以抑制DDR1和DDR2的酪氨酸激酶活化,并预防或治疗癌症,动脉硬化,类风湿性关节炎和骨关节炎。 构成:酪氨酸激酶抑制化合物由化学式1表示。用于抗癌的药物组合物含有化学式1,异构体或其药学上可接受的盐作为活性成分的化合物。 药学上可接受的盐是盐酸盐或三氟乙酸盐。 用于预防或治疗风湿病或骨关节炎的药物组合物含有化学式1,异构体和盐作为活性成分的化合物。

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