公开(公告)号：KR100590137B1

公开(公告)日：2006-06-15

申请号：KR1020030002289

申请日：2003-01-14

Applicant: 한국과학기술연구원

Inventor： 김영하 ,  김수현 ,  김지흥

IPC: C07C309/21

Abstract: 본 발명은 술폰산화 폴리에틸렌옥시드(PEO, poly(ethylene oxide))를 함유하는 비닐 단량체와 그 중합체 및 그들의 제조 방법에 관한 것이다.
본 발명의 단량체로 이루어진 중합체 및 표면 그라프트 개질체는 항혈전성이 우수하므로 혈액과 접촉되는 의료용 소재로 응용할 수 있다.
술폰산화 PEO 함유 비닐 단량체, 항혈전성 중합체, 의료용 재료

公开(公告)号：KR1020040065348A

公开(公告)日：2004-07-22

申请号：KR1020030002289

申请日：2003-01-14

Applicant: 한국과학기술연구원

Inventor： 김영하 ,  김수현 ,  김지흥

IPC: C07C309/21

Abstract: PURPOSE: Provided are a vinyl monomer comprising sulfonated poly(ethylene oxide), its polymer which shows excellent antithrombotic property and can be applied as a material of medical instrument, and a method for preparing the monomer and the polymer. CONSTITUTION: The vinyl monomer is represented by formula 1: CH2=CR-X-NH-A-O-(CH2-CH2-O)n-B-NH-(CH2)3-SO3H(wherein R is -H or CH3, X is -CO-, -CO-O-CH2-CH2-NH-CO-, -CH2-NH-CO- or -CH2, -O-CHOH-CH2-, -A- and -B-, which are same or different, represent -(CH2)-m-, m is 2 or 3, n is 100-200). The vinyl monomer is prepared by the method comprising replacing only amino group at one end of poly(ethylene oxide)(PEO) having both ends substituted with amino group, with sulfonic acid group, and reacting an amino group at the other end of PEO with vinyl compound having vinyl group.

Abstract translation: 目的：提供包含磺化聚（环氧乙烷）的乙烯基单体，其聚合物显示出优异的抗血栓形成性质并且可以用作医疗器械的材料，以及制备单体和聚合物的方法。 构成：乙烯基单体由式1表示：CH2 = CR-X-NH-AO-（CH2-CH2-O）nB-NH-（CH2）3-SO3H（其中R是-H或CH3，X是 - CO-，-CO-O-CH2-CH2-NH-CO-，-CH2-NH-CO-或-CH2，-O-CHOH-CH2-，-A-和-B-，它们相同或不同， 表示 - （CH 2）m - ，m为2或3，n为100-200）。 乙烯基单体通过以下方法制备，该方法包括仅将两端用氨基取代的聚（环氧乙烷）（PEO）的一端与磺酸基取代，并将PEO另一端的氨基与 具有乙烯基的乙烯基化合物。