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公开(公告)号：KR1020020041713A
公开(公告)日：2002-06-03
申请号：KR1020000071402
申请日：2000-11-28
Applicant: 한국과학기술연구원
IPC: G01N30/72
Abstract: PURPOSE: Provided is a detection method of bisphenol-A among foods or foods packing material which shows selective and superior sensitivity for gas chromatography(GC) or GC/mass spectrometer so that it provides optimal analysis condition for the GC/mass spectrometer. CONSTITUTION: The detection method of bisphenol-A among the foods or the foods packing material comprises the steps of: (i) extracting bisphenol-A from the foods or the foods packing material in organic solvent and treating in sodium hydroxide; (ii) reacting with 100-1400μl of anhydrous acetic acid at 25-100deg.C for 5-20 minutes to produce derivatives of bisphenol-A; and (iii) analyzing concentration of bisphenol-A at the GC or the GC/mass spectrometer.
Abstract translation: 目的：提供食品或食品包装材料中双酚A的检测方法，对气相色谱（GC）或GC /质谱仪具有选择性和优异的灵敏度，为GC /质谱仪提供最佳分析条件。 构成：食品或食品包装材料中双酚A的检测方法包括以下步骤：（i）从有机溶剂中的食品或食品包装材料中提取双酚A，并在氢氧化钠中处理; （ii）在25-100℃下与100-1400μl无水乙酸反应5-20分钟，得到双酚-A的衍生物; 和（iii）分析双酚A在GC或GC /质谱仪上的浓度。
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公开(公告)号：KR100379757B1
公开(公告)日：2003-04-11
申请号：KR1020000071402
申请日：2000-11-28
Applicant: 한국과학기술연구원
IPC: G01N30/72
Abstract: PURPOSE: Provided is a detection method of bisphenol-A among foods or foods packing material which shows selective and superior sensitivity for gas chromatography(GC) or GC/mass spectrometer so that it provides optimal analysis condition for the GC/mass spectrometer. CONSTITUTION: The detection method of bisphenol-A among the foods or the foods packing material comprises the steps of: (i) extracting bisphenol-A from the foods or the foods packing material in organic solvent and treating in sodium hydroxide; (ii) reacting with 100-1400μl of anhydrous acetic acid at 25-100deg.C for 5-20 minutes to produce derivatives of bisphenol-A; and (iii) analyzing concentration of bisphenol-A at the GC or the GC/mass spectrometer.
Abstract translation: 用途：本发明提供一种食品或食品包装材料中的双酚A检测方法，其对气相色谱（GC）或GC /质谱仪显示选择性和优异的灵敏度，从而为GC /质谱仪提供最佳分析条件。 构成：在食品或食品包装材料中检测双酚A的方法包括以下步骤：（i）从食品或食品包装材料中用有机溶剂提取双酚-A并用氢氧化钠处理; （ii）在25-100℃与100-1400μl无水乙酸反应5-20分钟以产生双酚-A衍生物; 和（iii）分析GC或GC /质谱仪处双酚A的浓度。
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公开(公告)号：KR100356267B1
公开(公告)日：2002-10-18
申请号：KR1019990048799
申请日：1999-11-05
Applicant: 한국과학기술연구원
IPC: G01N1/18
Abstract: 본발명은솔리드페이즈마이크로익스트랙션(Solid Phase Microextraction)(SPME)을위한용액사전처리인서트라이너에관한것으로서, 본발명은바이알에삽입되고파이버및 용액이내부로유도될수 있는내부공간을가지는본체와, 용액이통과하며불순물이여과되는필터로이루어지는에스피엠이용인서트라이너를제공한다. 상기본체는바람직하게는유리재질의원통형이고, 상기필터는 20-50㎛메쉬사이즈의유리필터일수 있다. 또한, 상기인서트라이너는추가적으로상기본체를바이알에보지하기위한홀더를구비할수 있는데, 여기서상기홀더는상기본체외측에끼워맞춤되고, 상기바이알의개구에걸리도록하는링-형상을할 수있다.
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公开(公告)号：KR1020010045492A
公开(公告)日：2001-06-05
申请号：KR1019990048799
申请日：1999-11-05
Applicant: 한국과학기술연구원
IPC: G01N1/18
Abstract: PURPOSE: An insert liner for a solid phase microextraction(SPME) is provided to extract organic compounds by using an SPME device even in a solution containing various mixed dregs and particles, wherein the insert liner is easily attached on or detached from the solid phase microextraction without any influence on the performance of the SPME device. CONSTITUTION: An insert liner for a solid phase microextraction(SPME) includes a main body(1) to be inserted into a vial and having an internal space for guiding fibers and solutions, a filter(2) for passing through the solutions for filtering impurities, and a holder(3a) for supporting the main body in the vial, wherein the main body is made of glass in the shape of a cylinder, the filter is to be glass filter having a mesh size of 20-50μm, and the holder is fitted into the outside of the main body and formed in the shape of a ring to be locked in an opening of the vial.
Abstract translation: 目的：提供用于固相微萃取（SPME）的插入衬垫，通过使用SPME装置甚至在含有各种混合渣和颗粒的溶液中提取有机化合物，其中插入衬垫容易地附着在固相微萃取物上或从固相微萃取物脱离 对SPME设备的性能没有任何影响。 构成：用于固相微萃取（SPME）的插入衬垫包括插入小瓶中并具有用于引导纤维和溶液的内部空间的主体（1），用于通过用于过滤杂质的溶液的过滤器（2） 和用于将主体支撑在小瓶中的保持器（3a），其中主体由圆柱形的玻璃制成，过滤器为网眼尺寸为20-50μm的玻璃过滤器，并且保持器 被装配到主体的外部并形成为环形的形状以锁定在小瓶的开口中。
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Patent Agency Ranking
公开(公告)号：KR100330860B1
公开(公告)日：2002-04-03
申请号：KR1019990052105
申请日：1999-11-23
Applicant: 한국과학기술연구원
IPC: G01N33/546
Abstract: 본발명은호모시스테인의혈중농도를분석하는방법에관한것으로, 상기방법은호모시스테인을에틸클로로포르메이트및 2,2,3,3,3-펜타플루오로-1-프로판올과반응시켜호모시스테인을유도체화한후 그농도를결정하는것을특징으로한다. 상기방법은보다구체적으로는호모시스테인을에틸클로로포르메이트및 2,2,3,3,3-펜타플루오로프로판올과반응시켜호모시스테인을유도체화하고, 이를유기용매를사용하여추출한후, 기체크로마토그래피-전자포획검출기를사용하여호모시스테인의농도를분석하는것으로이루어진다. 본발명의방법에의해호모시스테인의혈중농도를분석할경우, 우수한감도, 분석시간의단축, 저비용및 편리성등을동시에얻을수 있다.
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公开(公告)号：KR1020020006834A
公开(公告)日：2002-01-26
申请号：KR1020000040281
申请日：2000-07-13
Applicant: 한국과학기술연구원
IPC: G01N33/493
Abstract: PURPOSE: A method for analyzing fenamate medicine in urine is provided to analyze fenamate medicines in urine simultaneously and obtain optimum analysis conditions with precision and convenience at a low cost. CONSTITUTION: In a method for analyzing fenamate medicine in urine, a sample including multi-components of fenamate medicine extracted from urine is reacted with a mixture of anhydrous pentafluoroprophion(PFPA) and 2,2,3,3,3,-pentafluoro-1-prophanol(PFP-OH) to obtain respective fenamate derivative mixtures, and the fenamate derivative mixtures are analyzed by using gas chromatography/anion chemical ionization mass analyzer(GC/NCI-MS).
Abstract translation: 目的：提供尿液中茴香碱药物分析方法，同时分析尿液中的甲氨蝶呤药物，并以低成本获得最佳分析条件。 构成：在尿液中分析茴香酸药物的方法中，将含有从尿中提取的芬太尼药物的多组分的样品与无水五氟磷（PFPA）和2,2,3,3,3-三氟-1- - 丙醇（PFP-OH），得到各自的甲酸酯衍生物混合物，并使用气相色谱/阴离子化学电离质量分析仪（GC / NCI-MS）分析甲酸酯衍生物混合物。
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公开(公告)号：KR100352984B1
公开(公告)日：2002-09-18
申请号：KR1020000039340
申请日：2000-07-10
Applicant: 한국과학기술연구원
IPC: G01N33/48
Abstract: 본 발명은 혈중에 들어있는 중성지방과 몸에 해로운 저밀도저단백(LDL)-콜레스테롤을 낮추는 최신 고지혈증치료제인 혈장 중의 로바스타틴 산 (lovastatin acid)의 분석 방법에 관한 것으로서, 상기 방법은 디에틸에테르 및 소듐 설페이트를 사용하여 로바스타틴 산을 추출하는 단계, 펜타플루오로벤질 브로마이드 및 N-메틸-N-트리메틸실릴트리플루오로아세트아미드를 사용하여 로바스타틴 산을 유도체화하는 단계 및 유도체화된 로바스타틴 산을 기체 크로마토그래피/음이온 화학이온화 질량분석기로 분석하는 단계를 포함하는 것을 특징으로 하며, 보다 구체적으로는 산을 이용하여 혈장시료의 pH를 2이하로 조절하는 단계, 디에틸에테르 및 소듐 설페이트를 사용하여 혈장 중의 로바스타틴 산을 선택적으로 추출하는 단계, 추출된 로바스타틴 산을 펜타플 루오로벤질 브로마이드 및 N-메틸-N-트리메틸실릴트리플루오로아세트아미드를 사용하여 유도체화하는 단계 및 유도체화된 로바스타틴 산을 암모니아 기체를 시약 기체로 사용한 기체 크로마토그래피/음이온 화학이온화 질량분석기로 분석하는 단계를 포함하는 것을 특징으로 한다.
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公开(公告)号：KR1020020005862A
公开(公告)日：2002-01-18
申请号：KR1020000039340
申请日：2000-07-10
Applicant: 한국과학기술연구원
IPC: G01N33/48
Abstract: PURPOSE: An analysis process of lovastatin acid in blood serum is provided, therefore it can be effectively used in various applications of lovastatin acid which is capable of decreasing the concentration of low density low protein(LDL) - cholesterol in a human. CONSTITUTION: The analysis process of lovastatin acid in serum comprises the steps of: adjusting the hydrogen concentration of a serum to below pH 2; selectively extracting lovastatin acid using diethylether and sodium sulfate; converting the lovastatin acid of the formula(2) into the lovastatin acid derivatives of the formula(3) using pentafluorobenzyl bromide and N-methyl-N-trimethylsilyltrifluoro acetamide; and analyzing the lovastatin acid derivatives using a liquid chromatography/negative chemical ionization mass spectrometer using ammonia gas as a reagent.
Abstract translation: 目的：提供血清中洛伐他汀酸的分析过程，因此可有效应用于能够降低人体内低密度低蛋白（LDL） - 胆固醇浓度的洛伐他汀酸的各种用途。 构成：血清中洛伐他汀酸的分析过程包括：将血清中的氢浓度调节至低于pH 2; 使用二乙醚和硫酸钠选择性提取洛伐他汀酸; 使用五氟苄基溴和N-甲基-N-三甲基甲硅烷基三氟乙酰胺将式（2）的洛伐他汀酸转化为式（3）的洛伐他汀酸衍生物; 并使用氨气作为试剂，使用液相色谱/负电化学电离质谱仪分析洛伐他汀酸衍生物。
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公开(公告)号：KR1020010047748A
公开(公告)日：2001-06-15
申请号：KR1019990052105
申请日：1999-11-23
Applicant: 한국과학기술연구원
IPC: G01N33/546
Abstract: PURPOSE: A method for analyzing a homocysteine concentration in blood is provided which is excellent in sensitivity, improvement of reproductivity, accuracy, shortening of analysis time, low cost and conveniency. CONSTITUTION: The method comprises steps of: (i) reacting homocysteine with ethyl chloroformate and 2,2,3,3,3-pentafluoro-1-propanol to prepare a derivative of homocysteine; (ii) extracting the homocysteine derivative with an organic solvent; and (iii) analyzing the clean-up homocysteine derivative by using a gas chromatography-electron capture detector.
Abstract translation: 目的：提供一种分析血液中高半胱氨酸浓度的方法，灵敏度优异，繁殖力好，准确度高，分析时间缩短，成本低廉等优点。 方法：该方法包括以下步骤：（i）使高半胱氨酸与氯甲酸乙酯和2,2,3,3,3-五氟-1-丙醇反应制备同型半胱氨酸的衍生物; （ii）用有机溶剂萃取同型半胱氨酸衍生物; 和（iii）通过使用气相色谱 - 电子捕获检测器分析清除同型半胱氨酸衍生物。
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