公开(公告)号：KR1020040043517A

公开(公告)日：2004-05-24

申请号：KR1020020071808

申请日：2002-11-19

Applicant: 한국과학기술연구원

Inventor： 최귀원 ,  배태수 ,  김정규 ,  이창양

IPC: C12M3/00

CPC classification number: C12M27/10 ,  C12M23/08 ,  C12M23/46 ,  Y10S623/911 ,  Y10S623/917 ,  Y10S623/924

Abstract: PURPOSE: A hybrid bioreactor for the cell culture is provided, thereby simultaneously applying a shear strain for stimulating the cell proliferation and a compressive strain for stimulating the cell differentiation to cells, so that the cell proliferation and the cell differentiation can be simultaneously stimulated in the bioreactor. CONSTITUTION: A hybrid bioreactor for the cell culture comprises numerous culture vessel assemblies(100); a compressive strain motor(5); a ball screw(90) connected to the compressive strain motor(5) to be moved together; a pressurizing plate(60) connected to the ball screw(90) to move vertically, and having numerous compressive strain supports(80) fixing the lower portion of each culture vessel assembly(100); a lower supporting plate(20) fixing the lower portion of each culture vessel assembly(100) and having numerous lower supporting blocks(70) with a gear tooth on the circumference surface; a shear strain motor(25); and a power transferring unit for transferring the rotation power of the shear strain motor(25) to the numerous lower supporting blocks(70).

Abstract translation: 目的：提供用于细胞培养的混合生物反应器，从而同时施加用于刺激细胞增殖的剪切应变和用于刺激细胞分化为细胞的压缩应变，使得细胞增殖和细胞分化可以在 生物反应器。 构成：用于细胞培养的杂交生物反应器包括许多培养容器组件（100）; 压缩应变马达（5）; 连接到所述压缩应变马达（5）一起移动的滚珠丝杠（90） 连接到所述滚珠丝杠（90）以垂直移动的加压板（60），并且具有固定所述培养容器组件（100）的下部的许多压缩应变支撑件（80）; 固定每个培养容器组件（100）的下部的下支撑板（20），并且在圆周表面上具有许多具有齿轮齿的下支撑块（70）; 剪切应变马达（25）; 以及用于将剪切应变马达（25）的旋转动力传递到多个下支撑块（70）的动力传递单元。

公开(公告)号：KR100452403B1

公开(公告)日：2004-10-12

申请号：KR1020020071808

申请日：2002-11-19

Applicant: 한국과학기술연구원

Inventor： 최귀원 ,  배태수 ,  김정규 ,  이창양

IPC: C12M3/00

CPC classification number: C12M27/10 ,  C12M23/08 ,  C12M23/46 ,  Y10S623/911 ,  Y10S623/917 ,  Y10S623/924

Abstract: A hybrid bioreactor for cell culture is disclosed. To simultaneously apply compressive strain for cell differentiation and shear strain for cell proliferation to cells, the hybrid bioreactor includes a plurality of reactor tube assemblies (100), a compressive strain motor (5), a shear strain motor (25), a lower anchor mount (20) having a plurality of toothed anchors (70) to respectively anchor the lower ends of the reactor tube assemblies (100) to the lower anchor mount (20), a ball screw (90) operated in conjunction with the compressive strain motor (5), an upper anchor mount (60) which engages with the ball screw (90) to vertically move upward and downward and having a plurality of compressive strain anchors (80) to anchor the upper ends of the reactor tube assemblies (100) to the upper anchor mount (60), a power transmission unit to transmit the rotating force of the shear strain motor (25) to the toothed anchors (70).

Abstract translation: 公开了一种用于细胞培养的混合生物反应器。 为了将细胞分化的压缩应变和细胞增殖的剪切应变同时施加到细胞，混合生物反应器包括多个反应管组件（100），压缩应变马达（5），剪切应变马达（25），下锚 （20），其具有多个带齿的锚固件（70），以将反应管组件（100）的下端分别固定到下锚定件安装件（20）;滚珠螺杆（90），其与压缩应变马达 （5）;与上述滚珠丝杠（90）卡合，上下升降，具有多个压缩应变固定件（80）以固定上述反应管组件（100）的上端的上部固定件安装件（60） 在所述上部固定座（60）上安装有动力传递单元，该动力传递单元将所述剪切应变马达（25）的旋转力传递给所述带齿锚固件（70）。