公开(公告)号：KR1020130111082A

公开(公告)日：2013-10-10

申请号：KR1020120033590

申请日：2012-03-30

Applicant: 한국과학기술연구원

Inventor： 김동진 ,  유경호 ,  김영수 ,  박웅서 ,  강용구 ,  김혜연 ,  김윤경 ,  박기덕 ,  김맹섭 ,  서귀현 ,  안영길

IPC: C07D413/12 ,  C07D307/86 ,  A61K31/421 ,  A61P25/00

CPC classification number: C07D413/12 ,  C07D307/81 ,  C07D405/12

Abstract: PURPOSE: An aminostyrylbenzofuran compound and a pharmaceutical composition containing the same are provided to prevent and treat neurodegenerative diseases caused by beta-amyloid fibrillation. CONSTITUTION: A compound is selected among an aminostyrylbenzofuran compound of chemical formula 1 and a pharmaceutically acceptable salt, an isomer, a hydrate, and a solvate thereof. A pharmaceutical composition which suppresses beta-fibrillation contains the compound as an active ingredient. A pharmaceutical composition for preventing or treating neurodegenerative diseases contains the compound as an active ingredient. The neurodegenerative diseases are senile dementia, stroke, Parkinson's disease, Huntington's disease, or bovine spongiform encephalopathy.

Abstract translation: 目的：提供氨基苯乙烯基苯并呋喃化合物和含有它们的药物组合物，以预防和治疗由β-淀粉样蛋白原纤颤引起的神经变性疾病。 构成：化合物选自化学式1的氨基苯乙烯基苯并呋喃化合物及其药学上可接受的盐，异构体，水合物和溶剂合物。 抑制β-原纤维化的药物组合物含有作为活性成分的化合物。 用于预防或治疗神经变性疾病的药物组合物含有该化合物作为活性成分。 神经变性疾病是老年性痴呆，中风，帕金森病，亨廷顿氏病或牛海绵状脑病。