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公开(公告)号：KR101418058B1
公开(公告)日：2014-07-11
申请号：KR1020110127052
申请日：2011-11-30
Applicant: 한국과학기술연구원
Abstract: 본 발명은 녹는점 이상으로 가열하여 녹였다가 녹는점 미만으로 식힌 강황 추출물 (tumeric extract) 또는 커큐민, 이들을 포함하는 조성물 및 제조방법에 대한 것이다. 녹인 후 식힌 강황 추출물 또는 커큐민은 무정형 (amorphous)을 이루며 결정성인 녹이지 않은 강황 추출물 또는 커큐민에 비해 생체적합성 용매인에 높은 용해도를 가진다.
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公开(公告)号：KR1020130060798A
公开(公告)日：2013-06-10
申请号：KR1020110127052
申请日：2011-11-30
Applicant: 한국과학기술연구원
CPC classification number: A23L27/10 , A23L33/105 , A23V2002/00 , A23V2250/2112 , A23V2300/14
Abstract: PURPOSE: An amorphous turmeric extract and amorphous curcumin are provided through cooling below a melting point after heating a turmeric extract or curcumin to reach above the melting point. CONSTITUTION: An organic solvent extract of turmeric is obtained in a pure solution state by extracting turmeric with a solvent and filtering. The turmeric extract is heated at a range of 180-240 deg. C for 0.1-10 minutes, and amorphous curcumin is obtained by cooling with a temperature below 190 deg. C. A solubilization component of the turmeric extract includes an amorphous turmeric extract solution in which the amorphous turmeric extract is dissolved in a biocompatible solvent selected from one or more of a group composed of linear alcohol or branched alcohol with 1-4 carbons, poly ethylene glycol with 100-1,000 number average molecular weight, glycerol, acetic acid, and polyoxyethylene sorbitan fatty acid ester. [Reference numerals] (AA) Turmeric extract; (BB) Melted turmeric extract
Abstract translation: 目的：在加热姜黄提取物或姜黄素达到熔点以上之后，通过冷却至熔点以下，提供无定形姜黄提取物和无定形姜黄素。 构成：通过用溶剂萃取姜黄并进行过滤，得到纯溶液状态的姜黄有机溶剂提取物。 姜黄提取物在180-240度的范围内加热。 0.1至10分钟，通过在低于190度的温度下冷却获得无定形姜黄素。 C.姜黄提取物的增溶组分包括无定形姜黄提取物溶液，其中无定形姜黄提取物溶解在生物相容性溶剂中，所述生物相容性溶剂选自一种或多种由具有1-4个碳的直链醇或支链醇组成的组，聚乙烯 具有100-1,000数均分子量的二醇，甘油，乙酸和聚氧乙烯山梨糖醇酐脂肪酸酯。 （AA）姜黄提取物; （BB）熔黄姜提取物
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