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公开(公告)号：KR1020170125255A
公开(公告)日：2017-11-14
申请号：KR1020160055552
申请日：2016-05-04
CPC classification number: C09J11/08 , C08K5/00 , C08K2201/007 , C08L5/04 , C08L5/08 , C09J11/06 , C09J133/00
Abstract: 본발명은향오일점착제조성물및 그제조방법에관한것이다. 본발명의일 실시예에따른향오일점착제조성물제조방법은. (a) 키토산(Chitosan) 고분자를포함하는고분자수용액을제조하는단계(S10), (b) 고분자수용액에향오일(Fragrance Oil)을혼합하여향오일에멀젼을제조하는단계(S20), 및 (c) 상기향오일에멀젼을아크릴계점착제와혼합하는단계(S30)를포함한다.
Abstract translation: 香料油压敏粘合剂组合物及其制备方法本发明涉及香料油压敏粘合剂组合物及其制备方法。 根据本发明实施方案的生产香料油粘合剂组合物的方法包括： （A）脱乙酰壳多糖（壳聚糖）混合阶段（S10），（B）芳香油（芳香油）在聚合物水溶液，以制备包含聚合物来制备风味油乳液（S20）的聚合物溶液，和（c ）将香料油乳液与丙烯酸粘合剂混合（S30）。
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公开(公告)号：KR101371361B1
公开(公告)日：2014-03-07
申请号：KR1020120137304
申请日：2012-11-29
Applicant: 한국과학기술연구원
Abstract: The present invention relates to a method for quantifying fatty oil using means IV, and more specifically, to a method for quantifying fatty oil in a living body using means IV. According to one embodiment of the present invention, liquid chromatography (Nanospace SI-2, Shiseido co. Ltd, Tokyo, Japan) with high performance using a sunfire C8 column is used to separate an analyte (triolein, diolein, and monoolein) from an extracted solution. [Reference numerals] (AA) Weight of oil(mg) converted to Sudan IV; (BB) Weight of oil(mg) analyzed to LC/MS; (CC) Sudan recovery rate/Oil recovery rate; (DD) Amount of injected oil(쨉L)
Abstract translation: 本发明涉及使用方法IV定量脂肪油的方法，更具体地，涉及使用方法IV定量生物体中的脂肪油的方法。 根据本发明的一个实施方案，使用具有高性能的Sunfire C8柱的液相色谱（Nanospace SI-2，Shiseido co。Ltd，Tokyo，Japan）将分析物（三油酸甘油酯，二油烯和单油酸酯）从 提取溶液。 （附图标记）（AA）转换为苏丹的油重量（mg）IV; （BB）油液重量（mg）分析至LC / MS; （CC）苏丹回收率/回收率; （DD）注油量（쨉L）
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公开(公告)号：KR101088133B1
公开(公告)日：2011-12-02
申请号：KR1020090055909
申请日：2009-06-23
Applicant: 한국과학기술연구원
IPC: A01K29/00
Abstract: 설치류가 자신의 몸을 핥는 것을 방지하기 위해 착용하는 보호 칼라에 있어서 설치류가 받는 스트레스를 적게하고, 섭식 및 행동을 자유롭게 할 수 있는 설치류용 보호 칼라를 제공한다. 설치류용 보호 칼라는 내외지름이 서로 상이한 박판을 링형상으로 형성하며, 설치류의 목부분에 장착되는 칼라부재, 칼라부재의 일측에 형성되어 설치류의 앞다리에 장착되며, 칼라부재의 장착상태를 지지하는 지지부재를 포함한다.
설치류, 보호, 칼라, 목, 지지-
公开(公告)号：KR101049935B1
公开(公告)日：2011-07-15
申请号：KR1020080121802
申请日：2008-12-03
Applicant: 한국과학기술연구원
Inventor： 한호규 , 신동윤 , 남기달 , 한민수 , 서선희 , 정혜진 , 김윤지 , 송치만 , 마혜덕 , 백이연 , 최기현 , 신계정 , 노은주 , 배애님 , 신희섭 , 김동진 , 최경일 , 임혜원 , 남길수 , 조용서 , 추현아 , 강순방 , 정찬성 , 김은경 , 정혜선 , 김기선 , 금교창 , 이철주 , 민선준 , 이재균 , 강용구 , 박웅서 , 김영수
IPC: C07D277/28 , A61P25/00 , A61P9/00 , A61P35/00
Abstract: 본 발명은 아래의 화학식 1의 구조를 갖는 티아졸린계 화합물 및 이를 포함하는 T-형 칼슘 채널 저해제에 관한 것이다. 본 발명의 T-형 칼슘 채널 저해제는 T-형 칼슘 채널의 과다 발현과 관련된 질병의 치료제로서 유용하다.
(화학식 1)Abstract translation: 本发明涉及具有由下式（1）表示的结构的噻唑啉类化合物和含有其的T型钙通道抑制剂。 本发明的T型钙通道抑制剂可用作与T型钙通道过表达有关的疾病的治疗剂。
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公开(公告)号：KR1020100137720A
公开(公告)日：2010-12-31
申请号：KR1020090055909
申请日：2009-06-23
Applicant: 한국과학기술연구원
IPC: A01K29/00
CPC classification number: A01K13/006
Abstract: PURPOSE: A rodent protection collar is provided, which reduces stress of rodent and makes feeding and action free. CONSTITUTION: A rodent protection collar comprises: a color member(10) which a thin plate into a ring shape and is mounted on the cervical region of rodent; and a supporting member(20) which is formed in one side of the color member, is installed to the forelegs of rodent, and supports the mounted state of the color member. The color member and supporting member are integrally formed.
Abstract translation: 目的：提供啮齿动物保护套圈，减少啮齿动物的压力，使饲养和动作无效。 构成：啮齿动物保护套环包括：彩色构件（10），薄板形成环形并安装在啮齿动物的颈部区域; 以及形成在彩色构件的一侧的支撑构件（20）安装在啮齿动物的前肢上，并且支撑着彩色构件的安装状态。 彩色构件和支撑构件一体形成。
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Patent Agency Ranking
公开(公告)号：KR1020100001288A
公开(公告)日：2010-01-06
申请号：KR1020080061148
申请日：2008-06-26
Applicant: 한국과학기술연구원
Inventor： 최경일 , 남길수 , 김혜란 , 임혜원 , 서선희 , 백이연 , 김윤지 , 신희섭 , 김동진 , 배애님 , 정혜진 , 조용서 , 추현아 , 노은주 , 강순방 , 신계정 , 한호규 , 신동윤 , 정찬성 , 남기달 , 강용구 , 이재균 , 박웅서 , 김영수 , 김은경 , 김기선 , 정혜선 , 금교창 , 이철주 , 최기현
IPC: C07D233/61
CPC classification number: C07D233/60 , C07D209/48 , C07D233/54 , C07D233/61 , C07D403/06
Abstract: PURPOSE: A novel imidazolylalkylcarbonyl derivative which is effective as calcium ion channel regulator is provided to effectively block T-type calcium ion channel, prevent and treat brain diseases, heart diseases and pain. CONSTITUTION: An imidazolylalkylcarbonyl derivative is denoted by chemical formula 1. The imidazolylalkylcarbonyl derivative of chemical formula 1 is prepared by performing amide bond of piperazine derivative of chemical formula 3 with imidazolylalkylcarboxylic acid of chemical formula 2. The amide bond is performed using binder selected from phosphonium system, ammonium system, carbodiimide system, imidazolinium, and organic phosphine system. A method for preparing the imidazolylalkylcarboxylic acid of chemical formula 2 comprises: a step of performing hetero-michael addition reaction of ethy alkenoate with imidazole compound under the presence of KF/Al2O3 catalyst to produce ethoxycarbonylalkylimidazole compound of chemical formula 2a; and a step of hydrolyzing the ethoxycarbonylalkylimidazole compound of chemical formula 2a to prepare imidazolylalkylcarboxylic acid of chemical formula 2.
Abstract translation: 目的：提供一种有效阻断T型钙离子通道，预防和治疗脑疾病，心脏病和疼痛的新型咪唑烷基羰基衍生物，作为钙离子通道调节剂有效。 构成：化学式1表示咪唑烷基羰基衍生物。化学式1的咪唑烷基羰基衍生物通过化学式3的哌嗪衍生物与化学式2的咪唑基烷基羧酸的酰胺键进行制备。酰胺键使用选自鏻 系统，铵系统，碳二亚胺系统，咪唑啉鎓和有机膦系统。 制备化学式2的咪唑基烷基羧酸的方法包括：在KF / Al 2 O 3催化剂存在下，进行异丁烯酸乙酯与咪唑化合物的异迈克尔加成反应，生成化学式2a的乙氧基羰基烷基咪唑化合物的步骤; 以及水解化学式2a的乙氧基羰基烷基咪唑化合物以制备化学式2的咪唑基烷基羧酸的步骤。
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公开(公告)号：KR1020050008323A
公开(公告)日：2005-01-21
申请号：KR1020030048240
申请日：2003-07-15
Applicant: 한국과학기술연구원 , 주식회사 스마트세이프존
IPC: C08B37/08
Abstract: PURPOSE: Provided is a chitosan composite containing a hydrophobic group, which can encapsulate various hydrophobic pharmaceuticals and therapeutic proteins to give excellent biocompatibility and biodegradability, and thus is useful for pharmaceutical carrier. CONSTITUTION: The chitosan composite containing a hydrophobic group forms a nanosized self-aggregate in aqueous solution. Particularly, an amino group of chitosan is coupled with a carboxyl group of hydrophobic bile acid to form a nanosized self-aggregate. The chitosan is selected from the group consisting of water soluble glycol chitosan, chitosan oligomer and 50%-acetylated chitosan. The hydrophobic bile acid is selected from the group consisting of cholic acid, chenodeoxycholic acid, deoxycholic acid, lithocholic acid, 7-oxo-lithocholic acid and 5-beta-cholanic acid.
Abstract translation: 目的：提供一种含有疏水基团的壳聚糖复合物，其可以包封各种疏水性药物和治疗性蛋白质，以提供优异的生物相容性和生物降解性，因此可用于药物载体。 构成：含有疏水基团的壳聚糖复合物在水溶液中形成纳米尺寸的自聚集体。 特别地，壳聚糖的氨基与疏水性胆汁酸的羧基结合形成纳米化的自聚集体。 壳聚糖选自水溶性乙二醇壳聚糖，壳聚糖低聚物和50％乙酰化壳聚糖。 疏水性胆汁酸选自胆酸，鹅脱氧胆酸，脱氧胆酸，石胆酸，7-氧代 - 石胆酸和5-β-胆碱酸。
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公开(公告)号：KR100428418B1
公开(公告)日：2004-04-28
申请号：KR1020020011040
申请日：2002-02-28
Applicant: 한국과학기술연구원
IPC: A61K9/107
Abstract: PURPOSE: A process of preparing a fat emulsion using oils having higher specific gravity than water as a fat emulsion base material and amphoteric surfactants as an emulsifier is provided. The fat emulsion exhibits excellent expression efficiency in adhesive cell lines as well as in the presence of serum as compared to conventional liposome or squalane-based fat emulsion formulation and thus permits easy in-vitro assay of gene expression efficiency. CONSTITUTION: A fat emulsion comprises: 2 to 30% by weight of oil mixtures comprising iodized oil and one or more glyceride-based oils such as squalene or squalane as a fat emulsion base; 0.01 to 40% by weight of one or more amphoteric surfactants; 0.01 to 10% by weight of hydrophilic polymers, phospholipid combined with hydrophilic polymers or polymerizable phospholipid; 0.01 to 10% by weight of glycerol, soluble peptide or soluble protein; and the balance comprising water. The oil mixtures contain 40% by weight of iodized oil selected from the group consisting of iodized poppy seed oil.
Abstract translation: 目的：提供一种使用比重比水高的油作为脂肪乳剂基础材料和两性表面活性剂作为乳化剂制备脂肪乳剂的方法。 与常规脂质体或角鲨烷基脂肪乳剂制剂相比，脂质乳剂在粘附细胞系以及血清存在下表现出优异的表达效率，因此允许基因表达效率的体外容易测定。 组成：脂肪乳剂包含：2-30重量％的包含碘化油和一种或多种甘油酯基油例如角鲨烯或角鲨烷作为脂肪乳剂基质的油混合物; 0.01至40重量％的一种或多种两性表面活性剂; 0.01至10重量％的亲水性聚合物，与亲水性聚合物或可聚合磷脂结合的磷脂; 0.01至10重量％的甘油，可溶性肽或可溶性蛋白质; 余量包含水。 油混合物含有40重量％的选自碘化罂粟籽油的碘化油。
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公开(公告)号：KR100342835B1
公开(公告)日：2002-07-02
申请号：KR1019990031339
申请日：1999-07-30
Applicant: 한국과학기술연구원
IPC: A61K9/107
Abstract: 본발명은세포내로유전자 DNA 및생물학적활성약물을전달할수 있는비트리글리세라이드계열지방유제와트리글리세라이드또는에틸스테아레이트계지질미립구및 그들의제조방법에관한것이다. 또한본 발명은비트리글리세라이드계열지방유제와트리글리세라이드계열또는에틸스테아레이트지질미립구를사용하여세포내로 DNA 와같은생물학적활성약물을효과적으로전달하는방법에관한것이다. 또한본 발명은지용성및 소수성약물을함유한스쿠알렌또는스쿠알란을기재로한 지방유제와에틸스테아레이트를기재로한 지질미립구및 그들의제조방법에관한것이다.
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