公开(公告)号：KR102171242B1

公开(公告)日：2020-10-28

申请号：KR1020180116582

申请日：2018-09-28

Applicant: 한국과학기술연구원

Inventor： 유재상 ,  정하나 ,  최회길 ,  이헌수 ,  양철민 ,  홍현기 ,  오유나

IPC: C08K9/04 ,  C08J9/20 ,  C08K3/04 ,  C08L63/00 ,  C08L101/00 ,  C08J3/28

公开(公告)号：KR1020100005476A

公开(公告)日：2010-01-15

申请号：KR1020080065522

申请日：2008-07-07

Applicant: 한국과학기술연구원

Inventor： 조용서 ,  이재균 ,  오유나 ,  추현아 ,  배애님 ,  임혜원 ,  서선희

IPC: C07D403/12

CPC classification number: C07D401/12 ,  A61K31/454

Abstract: PURPOSE: An isoindolinone derivative having pharmaceutical activation to T-type calcium channel is provided to have antagonistic activity to T-type calcium channel and use as a therapeutic agent for hypertension, cancer, and neurogenic pain. CONSTITUTION: An isoindolinone derivative is denoted by chemical formula 1. In chemical formula 1, R1 is hydrogen atom, halogen atom, alkoxy group of C1-C6, haloalkyl group of C1-C6, nitro group, cyano group, or hydroxyl group. R2 is hydrogen atom, alkyl group of C1-C6, or aryl group. The isoindolinone derivative is obtained by reacting piperidinyl propylamine derivative of chemical formula 9 with isoindolinone carboxylic acid derivative of chemical formula 8 through amide reaction. A pharmaceutical composition for treating hypertension, cancer, epilepsy, and neurogenic pain contains the isoindolinone derivative and its pharmaceutically acceptable salt.

Abstract translation: 目的：提供具有T型钙通道药学活性的异吲哚啉酮衍生物，对T型钙通道具有拮抗作用，用作高血压，癌症和神经源性疼痛的治疗剂。 构成：异吲哚啉酮衍生物由化学式1表示。在化学式1中，R 1为氢原子，卤素原子，C 1 -C 6烷氧基，C 1 -C 6卤代烷基，硝基，氰基或羟基。 R2是氢原子，C1-C6烷基或芳基。 异吲哚啉酮衍生物通过化学式9的哌啶基丙胺衍生物与化学式8的异吲哚酮羧酸衍生物反应而得到。 用于治疗高血压，癌症，癫痫和神经原性疼痛的药物组合物含有异吲哚啉酮衍生物及其药学上可接受的盐。