-
公开(公告)号：KR1020000069800A
公开(公告)日：2000-11-25
申请号：KR1019997005944
申请日：1997-12-31
Applicant: 한국과학기술연구원
IPC: A61K9/19
CPC classification number: A61K9/7007 , Y10S514/953 , Y10S514/964 , Y10S514/975
Abstract: PURPOSE: A method of preparing a porous matrix-type drug delivery system by dispersing a drug-containing aqueous solution in an organic solvent in which a polymer compound and a surfactant are dissolved and forming the obtained emulsion into a desirable matrix shape is provided which can produce the titled system capable of being widely used for a therapeutic agent CONSTITUTION: The method for producing a porous matrix-type drug delivery system comprises the steps of: dispersing, stirring, and emulsifying an aqueous solution of a drug in an organic solvent having a polymer compound and a surface active agent solved therein; thereafter forming it into a desirable matrix shape; lyophilizing or drying it at a low temperature or room temperature until the matrix surface is hardened; and drying it again in order to remove the water and the organic solvent.
Abstract translation: 目的：提供一种通过将含药水溶液分散在其中溶解高分子化合物和表面活性剂的有机溶剂中并将所得乳液形成为期望的基质形状来制备多孔基质型药物递送系统的方法，其可以 制备能够广泛用于治疗剂的标题系统构成：多孔基质型药物递送系统的制备方法包括以下步骤：将药物的水溶液分散，搅拌和乳化在具有 高分子化合物和其中溶解的表面活性剂; 然后将其形成为期望的矩阵形状; 在低温或室温下冻干或干燥，直到基质表面硬化; 并再次干燥以除去水和有机溶剂。
-
公开(公告)号：KR100181252B1
公开(公告)日：1999-03-20
申请号：KR1019960082443
申请日：1996-12-31
Applicant: 한국과학기술연구원
IPC: A61K9/10
CPC classification number: A61K9/7007 , Y10S514/953 , Y10S514/964 , Y10S514/975
Abstract: 약물이 포함된 수용액을 고분자화합물과 계면활성제가 유기용매에 용해된 유기용액에 분산 교반시켜 에멀젼으로 만든 다음, 원하는 매트릭스 형태로 만들어 즉시 동결건조하거나 상온에서 일정시간 즉 매트릭스 표면이 경화되기 시작할 때까지 건조시킨 후 다시 진공건조하여 다공성 매트릭스를 제조하는 것을 특징으로 함.
-
公开(公告)号：KR100334435B1
公开(公告)日：2002-05-03
申请号：KR1019997005944
申请日：1997-12-31
Applicant: 한국과학기술연구원
IPC: A61K9/19
CPC classification number: A61K9/7007 , Y10S514/953 , Y10S514/964 , Y10S514/975
Abstract: 본발명은다공성매트릭스형약물전달제제를제조하는방법을제공한다. 상기방법은약물이포함된수용액을고분자화합물과계면활성제가유기용매에용해된유기용액에분산, 교반시켜에멀젼으로만든다음, 원하는매트릭스형태로만들어즉시동결건조하거나상온에서일정시간즉 매트릭스표면이경화되기시작할때까지건조시킨후 다시진공건조하여다공성매트릭스를제조하는것으로이루어진다.
-
-
Search Results
4
records
(took 0.018 seconds)
