公开(公告)号：KR1020010068458A

公开(公告)日：2001-07-23

申请号：KR1020000000385

申请日：2000-01-06

Applicant: 한국과학기술연구원

Inventor： 이철주 ,  류원석 ,  권익찬 ,  이세근 ,  한문희

IPC: C08J9/00

CPC classification number: C08J3/126 ,  C08F6/04 ,  C08F8/12 ,  C08J2331/04 ,  C08J2429/04 ,  Y10S525/902 ,  Y10S526/909 ,  C08F118/08

Abstract: PURPOSE: Provided is a preparation method of micro-spherical embolus material with duplex structure of polyvinylacetate (PVAc) core/polyvinyl alcohol (PVA) shell, which is used in the embolus treatment. In this treatment, the material is introduced to the blood vessels near the ailment spot where operation is not possible and it cutoffs the blood flow to cure the ailment such as hyper-vascular tumor, eases the symptoms caused by blood overflow and stops the bleeding by external wound or inflammatory bleeding of tuberculosis. Presently, polyvinyl alcohol is used as the embolus material but it brings side effect of inflammation presumably due to the sharp edges and ununiformity of the granules. CONSTITUTION: The preparation process for separating polyvinylacetate granules with uniform diameter of dispersant index of 1.00-1.6 comprises adding 0.1-100wt. parts (when PVAc wt. parts is 1) inorganic salts as dispersant and anti-static agent, wherein the salt is selected from sodium sulfate, sodium sulfite, sodium chloride, calcium sulfate and magnesium sulfate; milling PVAc granules; separating them to particles with desired size by using a standard sieve; and saponifying these granules only on the surface by suspending them in alkali aqueous solution containing NaOH, NaSO4, NaSO3 and methanol at 0 - 90deg.C so that the granules have double structure of PVAc core and PVA shell.

Abstract translation: 目的：提供一种用于栓塞治疗的聚乙酸乙烯酯（PVAc）芯/聚乙烯醇（PVA）壳双重结构的微球状栓塞材料的制备方法。 在这种治疗中，将材料引入到不可能操作的疾病斑点附近的血管中，并且阻断血流以治愈诸如高血管肿瘤的疾病，从而减轻由血液溢出引起的症状并且通过 外伤或结核病的炎性出血。 目前，使用聚乙烯醇作为栓塞材料，但是由于颗粒的锋利边缘和不均匀性而引起炎症的副作用。 构成：分散指数为1.00-1.6的均匀分散的聚乙酸乙烯酯颗粒的制备方法包括加入0.1-100wt。 部分（PVAc重量份为1）无机盐作为分散剂和抗静电剂，其中盐选自硫酸钠，亚硫酸钠，氯化钠，硫酸钙和硫酸镁; 研磨PVAc颗粒; 通过使用标准筛分成具有所需尺寸的颗粒; 并通过将其悬浮在含有NaOH，NaSO 4，NaSO 3和甲醇的碱性水溶液中，在0-90℃下将表面皂化，使颗粒具有PVAc芯和PVA壳的双重结构。

公开(公告)号：KR100335866B1

公开(公告)日：2002-05-10

申请号：KR1020000000385

申请日：2000-01-06

Applicant: 한국과학기술연구원

Inventor： 이철주 ,  류원석 ,  권익찬 ,  이세근 ,  한문희

IPC: C08J9/00

Abstract: 본 발명은 현탁 중합에 의해 제조된 다양한 입자 직경의 폴리아세트산비닐 입자를 분산제(分散劑) 겸 제전제(制電劑)로서 무기염을 사용하여 입자 직경 분포가 균일한 각각의 폴리아세트산비닐 입자로 분리하는 방법과, 이 분리된 폴리세트산비닐 입자를 알칼리 수용액에 현탁시켜 폴리아세트산비닐 입자의 표면에서만 불균일 표면 비누화 반응이 일어나게 함으로써 제조된 폴리아세트산비닐 코어(core)/폴리비닐알코올 외피(shell)의 2중 구조를 갖는 미세구형 색전재료 및 그의 제조 방법에 관한 것이다.