公开(公告)号：KR1019990068474A

公开(公告)日：1999-09-06

申请号：KR1019990018749

申请日：1999-05-25

Applicant: 한국과학기술연구원

Inventor： 최웅수 ,  권오관 ,  안병길 ,  오경근 ,  이승화

IPC: B01D39/16

CPC classification number: B01D39/1623 ,  B01D46/0001 ,  B01D46/0032 ,  B01D46/52 ,  B01D2239/10

Abstract: 본발명은공기압출방식을사용하여여러형태의고분자방사섬유필터소재를제조하면서, 이와동시에고분자방사섬유의표면전하밀도를증가시킴으로써필터소재에정전기가보유되어여과능이향상된에어필터소재및 그의제조방법에관한것이다.

公开(公告)号：KR100305282B1

公开(公告)日：2002-03-02

申请号：KR1019980047284

申请日：1998-11-05

Applicant: 한국과학기술연구원

Inventor： 이영익 ,  윤석원 ,  이승화

IPC: A61K36/47 ,  A61P25/08

Abstract: 본 발명은 간염 치료에 사용될 수 있는 필란두스 우리나리아 (Phyllanthus urinaria : 여우구슬풀) 추출물 및 그 제조방법에 관한 것으로서, 상세하게는 한국의 산야에 자생하는 잡초인 필란두스 우리나리아를 메탄올로 추출한 다음 건조보조제 등을 사용하여 수성 성분을 제외시키거나, 이에 더하여 실리카겔 칼럼, 젤 여과 칼럼 또는 고압 액체 칼럼 크로마토그래피 등을 수행하여 활성 성분을 더 정제하는 필란두스 우리나리아 추출물 및 그의 제조방법으로 구성되며, 본 발명의 추출물은 B형 간염 바이러스 e 항원 (HBeAg) 및 s 항원 (HBsAg)의 생성을 억제하고 분자 수준에서 바이러스의 증식도 저해하면서 세포 독성이 낮으므로 B형 간염 바이러스와 관련된 질환의 치료 및 간 기능 개선 등에 효과적으로 사용될 수 있다.

公开(公告)号：KR100310274B1

公开(公告)日：2001-11-02

申请号：KR1019990018749

申请日：1999-05-25

Applicant: 한국과학기술연구원

Inventor： 최웅수 ,  권오관 ,  안병길 ,  오경근 ,  이승화

IPC: B01D39/16

Abstract: PURPOSE: An electrostatic air filter is provided which improves filtration capability by manufacturing various types of filters spun with polymer fiber using air extrusion and increasing a surface charge density of the fiber at the same time, and a method for manufacturing the electrostatic air filter is provided. CONSTITUTION: The electrostatic air filter spun with polymer fiber of which surface charge density is increased is obtained by heating thus melting polymer resin(1) until it becomes a viscous fluid, spinning the molten material into micro polymer fiber before the material is deposited on a rotating target(5), and cooling the polymer fiber as the micro polymer fiber is being discharged with a corona discharger, wherein the target is in a drum or pleated shape, and the polymer resin(1) is polypropylene, polyethylene, or a mixture prepared by mixing polypropylene with polyethylene in a mixing ratio of 50:50. The method for manufacturing the electrostatic air filter spun with polymer fiber comprises the steps of heating thus melting a polymer material in an extruder(2) until it becomes a viscous fluid; depositing the molten polymer material on a revolving target(5), thereby forming a polymer spun fiber(4); and obtaining a polymer spun fiber(4) in which surface charge density is maximized, and static electricity is retained by cooling the deposited polymer spun fiber(4) as it is being discharged under a corona discharger, wherein an electric field of 10 to 40 kV is impressed to the corona, and the corona is positioned at the upper part of the spun fiber target(5).

公开(公告)号：KR1020000031308A

公开(公告)日：2000-06-05

申请号：KR1019980047284

申请日：1998-11-05

Applicant: 한국과학기술연구원

Inventor： 이영익 ,  윤석원 ,  이승화

IPC: A61K36/47 ,  A61P25/08

CPC classification number: A61K36/47 ,  A61K2236/33 ,  A61K2236/51

Abstract: PURPOSE: Provided are a Phyllanthus urinaria extract and production method thereof. Phyllanthus urinaria extract inhibits hepatitis B virus e antigen(HBeAg) and s antigen(HBsAg) production, suppresses proliferation of virus, and shows low toxicity therefore, it could be used for hepatitis therapy. CONSTITUTION: Phyllanthus urinaria is methanol-extracted using 3000 ml of methanol per100g of Phyllanthus urinaria at 40-60°C, and dehydrated by using 45-55g of magnesium sulfate, celite, evaporator, or freeze dryer. The extract especially, having an anti viral activity is further purified by silicagel column, gel filtration column, high pressure liquid column chromatography. In which, gel filtration column is proceeded using sephadex column with 2 ml of mixture solvent of methanol and ethylacetate per a minute and keeping temperatures within 10°C, and high pressure liquid column chromatography uses C-18 reverse phase HPLC column and 1.5 ml of methanol per a minute as a solvent keeping temperatures within 10°C. Final extract provides a pharmaceutical composition for hepatitis therapy and immunofacilitation and the dosage thereof is preferably 50-200mg per a day for an adult.

Abstract translation: 目的：提供了一种枸杞子提取物及其制备方法。 叶黄芩提取物抑制乙型肝炎病毒e抗原（HBeAg）和s抗原（HBsAg）的产生，抑制病毒的增殖，因此毒性低，因此可用于肝炎治疗。 构成：在40-60℃下，每100g的叶黄芩，使用3000ml甲醇进行甲醇提取，并使用45-55g硫酸镁，硅藻土，蒸发器或冷冻干燥器进行脱水。 特别是具有抗病毒活性的提取物通过硅胶柱，凝胶过滤柱，高压液相色谱进一步纯化。 其中，使用sephadex柱，每分钟用2ml甲醇和乙酸乙酯的混合溶剂进行凝胶过滤柱，保持温度在10℃以内，高压液相柱层析使用C-18反相HPLC柱和1.5ml 甲醇每分钟作为溶剂，保持温度在10℃以内。 最终提取物提供用于肝炎治疗和免疫镇定的药物组合物，并且其用量优选为成人每天50-200mg。