公开(公告)号：KR100517097B1

公开(公告)日：2005-09-27

申请号：KR1020020084892

申请日：2002-12-27

Applicant: 한국과학기술연구원

Inventor： 김영하 ,  김수현 ,  이수홍 ,  전오주 ,  정성인

IPC: A61L31/04

Abstract: 본 발명은 뛰어난 유연성 및 적당한 가수분해성을 가진 생분해성 고분자 및 이 중합체로부터 형성된 다공성 지지체에 관한 것이다. 더욱 상세히 말하자면, 본 발명은 생분해성 재료인 락타이드와 ε-카프로락톤을 이용하여 중량 평균 분자량이 10,000 이상인 락타이드/ε-카프로락톤의 생분해성 공중합체를 제조하고, 이를 이용하여 상처피복재, 세포 배양용 지지체 재료로 사용 가능한 다공성 지지체 제조에 관한 것이다.

公开(公告)号：KR1020040058572A

公开(公告)日：2004-07-05

申请号：KR1020020084892

申请日：2002-12-27

Applicant: 한국과학기술연구원

Inventor： 김영하 ,  김수현 ,  이수홍 ,  전오주 ,  정성인

IPC: A61L31/04

Abstract: PURPOSE: Provided is a porous support obtained from biodegradable lactide/epsilon-caprolactone copolymer, which has excellent mechanical properties including flexibility and elasticity suitable to be used in tissue engineering. CONSTITUTION: The porous support obtained from biodegradable lactide/ epsilon-caprolactone copolymer has repeating units represented by formula 1 and a weight average molecular weight of 10,000 or more, wherein the mole ratio of lactide to epsilon-caprolactone is 2:8 to 8:2: wherein each of x and y is an integer of 1 or more, and n is an integer of 18 or more. Particularly, the porous support has a pore size of 1 to 800 micrometers and a porosity of 50-99%.

Abstract translation: 目的：提供由生物可降解丙交酯/ε-己内酯共聚物获得的多孔载体，其具有优异的机械性能，包括适合用于组织工程的柔性和弹性。 构成：由生物可降解丙交酯/ε-己内酯共聚物获得的多孔载体具有由式1表示的重复单元，重均分子量为10,000以上，其中丙交酯与ε-己内酯的摩尔比为2：8〜8：2 ：其中x和y各自为1以上的整数，n为18以上的整数。 特别地，多孔载体的孔径为1至800微米，孔隙率为50-99％。

公开(公告)号：KR100453130B1

公开(公告)日：2004-10-15

申请号：KR1020010072538

申请日：2001-11-21

Applicant: 한국과학기술연구원

Inventor： 김영하 ,  김수현 ,  이수홍 ,  전오주

IPC: C08G81/00 ,  C08G63/08

CPC classification number: C08G63/08

Abstract: Disclosed is a sequentially ordered biodegradable lactide (or glycolide or lactide/glycolide)/epsilon-caprolactone multi-block copolymers having proper degradation properties and enhanced mechanical properties such as flexibility and elasticity and a process for the preparation thereof.

Abstract translation: 公开了一种顺序排序可生物降解的丙交酯（或乙或丙交酯/乙交酯）/具有适当的降解性能和增强的机械性能，例如柔韧性和弹性，以及就其制备方法ε-己内酯的多嵌段共聚物。

公开(公告)号：KR1020030041636A

公开(公告)日：2003-05-27

申请号：KR1020010072538

申请日：2001-11-21

Applicant: 한국과학기술연구원

Inventor： 김영하 ,  김수현 ,  이수홍 ,  전오주

IPC: C08G81/00 ,  C08G63/08

CPC classification number: C08G63/08

Abstract: PURPOSE: A biodegradable lactide(glycolide or lactide/glycolide)/ε-caprolactone multiblock copolymer having the uniform structural array and its preparation method are provided, wherein the copolymer shows excellent flexibility and elasticity and has a suitable degradation period applicable to a medical material. CONSTITUTION: The biodegradable multiblock copolymer is represented by -(A-COO-PCL-COO)n-, wherein A is polylactide, polyglycolide or polylactide/polyglycolide; PCL is poly(ε-caprolactone); and n is an integer of 2-2,000. Preferably the multiblock copolymer has a molecular weight of 2,000-500,000. The method comprises the steps of introducing an acyl halide to the end of polylactide, polyglycolide or polylactide/polyglycolide, or poly(ε-caprolactone); and coupling the introduced acyl halide with the hydroxy group of the end of the corresponding poly(ε-caprolactone) or polylactide, polyglycolide or polylactide/polyglycolide.

Abstract translation: 目的：提供具有均匀结构阵列的生物可降解丙交酯（乙交酯或丙交酯/乙交酯）/ε-己内酯多嵌段共聚物及其制备方法，其中共聚物显示出优异的柔韧性和弹性，并且具有适用于医疗材料的合适的降解期。 构成：可生物降解的多嵌段共聚物由 - （A-COO-PCL-COO）n-表示，其中A是聚丙交酯，聚乙交酯或聚丙交酯/聚乙交酯; PCL为聚（ε-己内酯）; n为2-2000的整数。 优选地，多嵌段共聚物的分子量为2,000-500,000。 该方法包括将酰卤引入聚丙交酯，聚乙交酯或聚丙交酯/聚乙交酯或聚（ε-己内酯）的末端的步骤; 并将引入的酰基卤与相应的聚（ε-己内酯）或聚丙交酯，聚乙交酯或聚丙交酯/聚乙交酯的末端的羟基偶合。