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公开(公告)号：KR101111247B1
公开(公告)日：2012-06-12
申请号：KR1020090065466
申请日：2009-07-17
Applicant: 한국과학기술연구원
IPC: C07D231/04 , C07D231/02
CPC classification number: C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14
Abstract: 본 발명은 신규 피라졸 화합물과 약제학적으로 허용 가능한 이의 염, 이 화합물의 제조방법, 그리고 이 화합물을 항암제로 사용하는 의약용도에 관한 것이다.
피라졸 화합물, 리셉터 타이로신 카이나제, Ros 단백질 저해제, 뇌암, 다형성 교아종, 항암제-
公开(公告)号：KR1020110007830A
公开(公告)日：2011-01-25
申请号：KR1020090065466
申请日：2009-07-17
Applicant: 한국과학기술연구원
IPC: C07D231/04 , C07D231/02
CPC classification number: C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14
Abstract: PURPOSE: A novel pyrazole compound I provided to ensure excellent activity on ROS kinase enzyme and to suppress development of glioblastoma multiforma, CNS cancer, and brain cancer. CONSTITUTION: A pyrazole compound is denoted by chemical formula 1. A pharmaceutical composition for anti-cancer contains the pyrazole compound. An anticancer agent contains the pyrazole compound as an active ingredient. The anticancer agent is used for treating brain cancer, CNS caner, and glioblastoma multiforma. A method for preparing the pyrazole compound comprises: a step of reacting a hetero aromatic compound of chemical formula 3 with methyl 3-methoxy-5-methoxybenzoate compound of chemical formula 2 under the presence of lithium hexamethyldisilazide(LHMDS) to obtain a keto-enol tautomer compound; and a step of reacting the keto-enol tauotmer compound with hydrazine hydrate under anhydrous ethanol condition.
Abstract translation: 目的：提供一种新的吡唑化合物I，以确保对ROS激酶的优异活性，并抑制多形性胶质母细胞瘤，CNS癌和脑癌的发展。 构成：吡唑化合物由化学式1表示。用于抗癌的药物组合物含有吡唑化合物。 抗癌剂含有吡唑化合物作为活性成分。 抗癌剂用于治疗脑癌，CNS癌和多形性成胶质细胞瘤。 制备吡唑化合物的方法包括：使化学式3的杂芳族化合物与化学式2的3-甲氧基-5-甲氧基苯甲酸甲酯在六甲基二硅叠氮化锂（LHMDS）存在下反应，得到酮 - 烯醇 互变异构体 以及在无水乙醇条件下使酮 - 烯醇葡聚糖化合物与水合肼反应的步骤。
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公开(公告)号：KR101306893B1
公开(公告)日：2013-09-10
申请号：KR1020110021512
申请日：2011-03-10
Abstract: 본 발명은 발광 특성을 갖는 나프토아크리딘 화합물에 관한 것으로서, 더욱 상세하게는 9
H -나프토[3,2,1-
kl ]아크리딘을 모핵으로 하고 C9 위치에 다양한 방향족 또는 헤테로방향족 그룹이 치환되어 있는 신규 구조의 화합물로서, 자외선 또는 가시광선에 의해 발광하는 특성을 나타내므로 형광염료, 형광체, 또는 유기 전계발광소자나 디스플레이의 발광재료로 유용한 나프토아크리딘 화합물에 관한 것이다.-
公开(公告)号：KR1020120103322A
公开(公告)日：2012-09-19
申请号：KR1020110021512
申请日：2011-03-10
CPC classification number: C07D219/00 , H01L51/0067 , H01L51/0072 , H05B33/20
Abstract: PURPOSE: A naphtoacridine compound is provided to be used as fluorescent or luminous dye, or to be used as fluorescent or luminous material for organic electroluminescence devices by having a property excited by a wavelength of UV rays or visible rays. CONSTITUTION: A naphtoacridine compound is in chemical formula 1. The naphtoacridine compound in chemical formula 1 is manufactured by witting reaction of 9H-naphtho[3,2,1-kl]acridin-9-one and triphenylphosphonium bromide in chemical formula 3. In the chemical formulas, R^1 and R^2 is the same or different each other, selected from a phenyl group, a biphenyl group, a naphthalene group, a pyridine group. The witting reaction is conducted with a base of C1-6 alkoxy alkali metal salt under the condition of inert condition.
Abstract translation: 目的：提供萘吖啶化合物用作荧光或发光染料，或者通过具有由紫外线或可见光线的波长激发的特性用作有机电致发光器件的荧光或发光材料。 化学式1中的萘吖啶化合物通过化学式3中9H-萘并[3,2,1-kl]吖啶-9-酮和三苯基溴化鏻的反应而制备。在 化学式R 1和R 2彼此相同或不同，选自苯基，联苯基，萘基，吡啶基。 在惰性条件下，用C1-6烷氧基碱金属盐的碱进行催化反应。
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