公开(公告)号：KR1020120079616A

公开(公告)日：2012-07-13

申请号：KR1020110000897

申请日：2011-01-05

Applicant: 한국과학기술연구원

Inventor： 배애님 ,  김은경 ,  금교창 ,  서선희 ,  홍승곤 ,  무하마드무다사

IPC: A61K31/435 ,  A61K31/4418 ,  A61P31/04 ,  A61P31/00

CPC classification number: A61K31/167 ,  A61K31/12 ,  A61K31/137 ,  A61K31/235 ,  A61K31/24 ,  A61K31/4035 ,  A61K31/4409 ,  Y10S514/924

Abstract: PURPOSE: An antibacterial agent containing novel diphenyl derivative or pharmaceutically acceptable salt thereof is provided to suppress bacterial fatty acid biosynthesis. CONSTITUTION: An antibacerial agent against mycobacteria contains a compound of chemical formula I or pharmaceutically acceptable salt thereof as an active ingredient. The mycobacteria are Mycobacterium tuberculosis. A composition for preventing or treating mycobacterium infections contains the compound or salt as an active ingredient. The mycobacterium infections are tuberculosis. The composition is manufactured in the form of a pharmaceutical composition administered to mammals and birds.

Abstract translation: 目的：提供含有新二苯衍生物或其药学上可接受的盐的抗菌剂以抑制细菌脂肪酸生物合成。 构成：抗分枝杆菌的抗菌剂含有化学式I的化合物或其药学上可接受的盐作为活性成分。 分枝杆菌是结核分枝杆菌。 用于预防或治疗分枝杆菌感染的组合物含有化合物或盐作为活性成分。 分枝杆菌感染是结核病。 该组合物以施用于哺乳动物和鸟类的药物组合物的形式制造。

公开(公告)号：KR101284174B1

公开(公告)日：2013-07-09

申请号：KR1020110000897

申请日：2011-01-05

Applicant: 한국과학기술연구원

Inventor： 배애님 ,  김은경 ,  금교창 ,  서선희 ,  홍승곤 ,  무하마드무다사

IPC: A61K31/435 ,  A61K31/4418 ,  A61P31/04 ,  A61P31/00

Abstract: 박테리아의 지방산 생합성을 억제하고, 마이코박테리아에 대한 항균제 및 감염 치료제로 유용한 신규 디페닐 유도체 또는 이의 약학적으로 허용되는 염, 및 이를 유효성분으로 함유하는 항균 조성물이 제공된다.

公开(公告)号：KR101124628B1

公开(公告)日：2012-06-12

申请号：KR1020090115388

申请日：2009-11-26

Applicant: 한국과학기술연구원

Inventor： 금교창 ,  김은경 ,  배애님 ,  서선희 ,  홍승곤 ,  바타라이디팍 ,  슬린코인나 ,  조상래

IPC: C07C235/32 ,  A61K31/165 ,  A01N37/18 ,  C07C231/02

CPC classification number: Y02A50/473 ,  Y02A50/481

Abstract: PURPOSE: A triclosan derivative is provided to inhibit the activity of a FabI strain and to enable use as an antimicrobial agent for tuberculous bacillus including introspection strains and various strains. CONSTITUTION: A triclosan derivative is represented by chemical formula 1. In chemical formula 1, n is an integer of 1-6; X is primary or secondary amine, C1-C4 alkylamine, C1-C6 alkylamine including at least one hetero atom selected from oxygen and nitrogen, C5-C10 heterocyclic amine including at least one hetero atom selected from oxygen and nitrogen, phenylamine including at least one hydroxy group, phenylamine in which C1-C4 alkyl ester group or carboxylic acid is substituted, and 6-membered heteroarylamine including at least nitrogen.

公开(公告)号：KR1020110058557A

公开(公告)日：2011-06-01

申请号：KR1020090115388

申请日：2009-11-26

Applicant: 한국과학기술연구원

Inventor： 금교창 ,  김은경 ,  배애님 ,  서선희 ,  홍승곤 ,  바타라이디팍 ,  슬린코인나 ,  조상래

IPC: C07C235/32 ,  A61K31/165 ,  A01N37/18 ,  C07C231/02

CPC classification number: Y02A50/473 ,  Y02A50/481

Abstract: PURPOSE: A triclosan derivative is provided to inhibit the activity of a FabI strain and to enable use as an antimicrobial agent for tuberculous bacillus including introspection strains and various strains. CONSTITUTION: A triclosan derivative is represented by chemical formula 1. In chemical formula 1, n is an integer of 1-6; X is primary or secondary amine, C1-C4 alkylamine, C1-C6 alkylamine including at least one hetero atom selected from oxygen and nitrogen, C5-C10 heterocyclic amine including at least one hetero atom selected from oxygen and nitrogen, phenylamine including at least one hydroxy group, phenylamine in which C1-C4 alkyl ester group or carboxylic acid is substituted, and 6-membered heteroarylamine including at least nitrogen.

Abstract translation: 目的：提供三氯生衍生物以抑制FabI菌株的活性，并且可用作结核菌杆菌的抗微生物剂，包括内省菌株和各种菌株。 构成：三氯生衍生物由化学式1表示。在化学式1中，n为1-6的整数; X是伯或仲胺，C 1 -C 4烷基胺，包括至少一个选自氧和氮的杂原子的C 1 -C 6烷基胺，包括至少一个选自氧和氮的杂原子的C 5 -C 10杂环胺，包括至少一个 羟基，其中C 1 -C 4烷基酯基或羧酸被取代的苯胺和至少包含氮的6元杂芳基胺。