公开(公告)号：KR101271224B1

公开(公告)日：2013-06-10

申请号：KR1020110066569

申请日：2011-07-05

Applicant: 한국과학기술연구원

Inventor： 금교창 ,  김은경 ,  배애님 ,  최경일 ,  강순방 ,  서선희 ,  바타라이디팍 ,  이주현

IPC: C07D413/10 ,  C07D413/14 ,  A61K31/422 ,  A61P31/04

CPC classification number: C07D413/10 ,  A61K31/422 ,  C07D413/14 ,  Y02A50/473 ,  Y02A50/481

Abstract: 본 발명은 항균활성을 갖는 신규한 이중고리를 포함하는 옥사졸리디논 유도체 또는 이의 약학적으로 허용 가능한 염, 이들의 제조방법, 및 상기 옥사졸리디논 유도체 또는 이의 약학적으로 허용 가능한 염을 유효성분으로 포함하는 항균 조성물에 관한 것으로서, 본 발명의 옥사졸리디논 유도체 또는 이의 약학적으로 허용 가능한 염은 다양한 내성 균주를 포함하는 그람 양성균에 대하여 우수한 항균 활성을 나타낸다.

公开(公告)号：KR1020130006554A

公开(公告)日：2013-01-17

申请号：KR1020110066569

申请日：2011-07-05

Applicant: 한국과학기술연구원

Inventor： 금교창 ,  김은경 ,  배애님 ,  최경일 ,  강순방 ,  서선희 ,  바타라이디팍 ,  이주현

IPC: C07D413/10 ,  C07D413/14 ,  A61K31/422 ,  A61P31/04

CPC classification number: C07D413/10 ,  A61K31/422 ,  C07D413/14 ,  Y02A50/473 ,  Y02A50/481

Abstract: PURPOSE: AN oxazolidinone derivative containing a novel cyclic group is provided to ensure excellent antibacterial activity against gram-positive bacteria including various resistant strains. CONSTITUTION: An oxazolidionone derivative containing a cyclopenta[c]pyloriphenyl group is denoted by chemical formula 1. An antibacterial composition contains the oxazolidinone derivative or a pharmaceutically acceptable salt thereof as an active ingredient. The antibacterial composition has antibacterial activity against Staphylococcus sp., Enterococcus sp., E.coli, Bacillus sp., Salmonella sp. or Mycobacterium.

Abstract translation: 目的：提供含有新环状基团的恶唑烷酮衍生物，以确保对包括各种抗性菌株在内的革兰氏阳性菌具有优异的抗菌活性。 构成：含有环戊二烯并[c]苯乙烯基的恶唑烷酮衍生物由化学式1表示。抗菌组合物含有恶唑烷酮衍生物或其药学上可接受的盐作为活性成分。 抗菌组合物对葡萄球菌属，肠球菌属，肠杆菌属，大肠杆菌属，芽孢杆菌属，沙门氏菌属， 或分枝杆菌。

公开(公告)号：KR101264903B1

公开(公告)日：2013-05-15

申请号：KR1020100117602

申请日：2010-11-24

Applicant: 한국과학기술연구원

Inventor： 금교창 ,  김은경 ,  배애님 ,  김유승 ,  강순방 ,  서선희 ,  바타라이디팍

IPC: C07D413/10 ,  A61K31/422 ,  A61P31/04

CPC classification number: Y02A50/473 ,  Y02A50/481

Abstract: 본발명은항균활성을갖는신규한옥사졸리디논유도체또는이의약학적으로허용가능한염, 이들의제조방법, 및상기옥사졸리디논유도체또는이의약학적으로허용가능한염을유효성분으로포함하는항균조성물에관한것으로서, 본발명의옥사졸리디논유도체또는이의약학적으로허용가능한염은다양한내성균주를포함하는그람양성균에대하여우수한항균활성을나타낸다.

公开(公告)号：KR1020120056078A

公开(公告)日：2012-06-01

申请号：KR1020100117602

申请日：2010-11-24

Applicant: 한국과학기술연구원

Inventor： 금교창 ,  김은경 ,  배애님 ,  김유승 ,  강순방 ,  서선희 ,  바타라이디팍

IPC: C07D413/10 ,  A61K31/422 ,  A61P31/04

CPC classification number: Y02A50/473 ,  Y02A50/481

Abstract: PURPOSE: An antibacterial composition containing novel oxazolidinone derivative is provided to ensure antibacterial activity against gram positive bacteria. CONSTITUTION: A novel oxazolidinone derivative with antibacterial activity is denoted by chemical formula 1. A method for preparing the compound of chemical formula 1 or the salt thereof comprises: a step of reacting an amine group of a compound of chemical formula 2 with a compound of chemical formula 3 or 4; and a step of substituting a hydroxyl group of an oxazolidinone derivative or a pharmaceutically acceptable salt thereof with a halogen group or methoxy group. An antibacterial composition contains the oxazolidinone derivative of chemical formula 1 or a salt thereof as an active ingredient.

Abstract translation: 目的：提供含有新恶唑烷酮衍生物的抗菌组合物，以确保对革兰氏阳性菌的抗菌活性。 构成：具有抗菌活性的新型恶唑烷酮衍生物由化学式1表示。化学式1化合物或其盐的制备方法包括：使化学式2的化合物的胺基与 化学式3或4; 以及将恶唑烷酮衍生物或其药学上可接受的盐的羟基与卤素基或甲氧基取代的步骤。 抗菌组合物含有化学式1的恶唑烷酮衍生物或其盐作为活性成分。

公开(公告)号：KR101124628B1

公开(公告)日：2012-06-12

申请号：KR1020090115388

申请日：2009-11-26

Applicant: 한국과학기술연구원

Inventor： 금교창 ,  김은경 ,  배애님 ,  서선희 ,  홍승곤 ,  바타라이디팍 ,  슬린코인나 ,  조상래

IPC: C07C235/32 ,  A61K31/165 ,  A01N37/18 ,  C07C231/02

CPC classification number: Y02A50/473 ,  Y02A50/481

Abstract: PURPOSE: A triclosan derivative is provided to inhibit the activity of a FabI strain and to enable use as an antimicrobial agent for tuberculous bacillus including introspection strains and various strains. CONSTITUTION: A triclosan derivative is represented by chemical formula 1. In chemical formula 1, n is an integer of 1-6; X is primary or secondary amine, C1-C4 alkylamine, C1-C6 alkylamine including at least one hetero atom selected from oxygen and nitrogen, C5-C10 heterocyclic amine including at least one hetero atom selected from oxygen and nitrogen, phenylamine including at least one hydroxy group, phenylamine in which C1-C4 alkyl ester group or carboxylic acid is substituted, and 6-membered heteroarylamine including at least nitrogen.

公开(公告)号：KR1020110058557A

公开(公告)日：2011-06-01

申请号：KR1020090115388

申请日：2009-11-26

Applicant: 한국과학기술연구원

Inventor： 금교창 ,  김은경 ,  배애님 ,  서선희 ,  홍승곤 ,  바타라이디팍 ,  슬린코인나 ,  조상래

IPC: C07C235/32 ,  A61K31/165 ,  A01N37/18 ,  C07C231/02

CPC classification number: Y02A50/473 ,  Y02A50/481

Abstract: PURPOSE: A triclosan derivative is provided to inhibit the activity of a FabI strain and to enable use as an antimicrobial agent for tuberculous bacillus including introspection strains and various strains. CONSTITUTION: A triclosan derivative is represented by chemical formula 1. In chemical formula 1, n is an integer of 1-6; X is primary or secondary amine, C1-C4 alkylamine, C1-C6 alkylamine including at least one hetero atom selected from oxygen and nitrogen, C5-C10 heterocyclic amine including at least one hetero atom selected from oxygen and nitrogen, phenylamine including at least one hydroxy group, phenylamine in which C1-C4 alkyl ester group or carboxylic acid is substituted, and 6-membered heteroarylamine including at least nitrogen.

Abstract translation: 目的：提供三氯生衍生物以抑制FabI菌株的活性，并且可用作结核菌杆菌的抗微生物剂，包括内省菌株和各种菌株。 构成：三氯生衍生物由化学式1表示。在化学式1中，n为1-6的整数; X是伯或仲胺，C 1 -C 4烷基胺，包括至少一个选自氧和氮的杂原子的C 1 -C 6烷基胺，包括至少一个选自氧和氮的杂原子的C 5 -C 10杂环胺，包括至少一个 羟基，其中C 1 -C 4烷基酯基或羧酸被取代的苯胺和至少包含氮的6元杂芳基胺。