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公开(公告)号：KR1020120094711A
公开(公告)日：2012-08-27
申请号：KR1020110014144
申请日：2011-02-17
Applicant: 한국과학기술연구원
Abstract: PURPOSE: A biomarker for myocardial hypertrophy diagnosis and a myocardial hypertrophy diagnosis method using the same are provided to judge myocardial hypertrophy from the biological material. CONSTITUTION: A biomarker for myocardial hypertrophy diagnosis comprises PDZ and LIM domain protein which have amino acid sequence described in sequence number 1(SEQ ID NO:1), ADP-ribosyl hydrolase which has amino acid sequence described in sequence number 2, peptidyl - prolyl cis-trans isomerase E which has amino acid sequence described in sequence number 3, translation extension element 1 delta isoform b of eukaryotic cells which has amino acid sequence described in sequence number 4, Ran- specific GTPase- activator protein which has amino acid sequence described in sequence number 5, ATP synthase subunit beta which has amino acid sequence described in sequence number 6, mitochondrial precursor, or isoform 1 of astrocytic phosphor protein PEA-15 which has amino acid sequence described in sequence number 7.
Abstract translation: 目的：提供用于心肌肥大诊断的生物标志物和使用其的心肌肥大诊断方法来判断生物材料的心肌肥大。 构成：心肌肥大诊断的生物标志物包括PDZ和LIM结构域蛋白，其具有序列号1（SEQ ID NO：1）中描述的氨基酸序列，ADP-核糖基水解酶，其具有序列号2中所述的氨基酸序列，肽基 - 脯氨酰 具有序列号3所示的氨基酸序列的顺式反式异构酶E，具有序列号4所述的氨基酸序列的具有所述氨基酸序列的Ran-特异性GTP酶 - 活化蛋白的真核细胞的翻译延伸元件1Δ同工型b 在序列号5中，具有序列号6所示氨基酸序列的ATP合成酶亚基β，具有序列号7所述的氨基酸序列的星形细胞磷酸蛋白PEA-15的线粒体前体或同种型1。
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公开(公告)号：KR101296743B1
公开(公告)日：2013-08-20
申请号：KR1020110014144
申请日：2011-02-17
Applicant: 한국과학기술연구원
Abstract: 본 발명은 심근 비대증 진단용 바이오마커 및 이를 이용한 심근 비대증 진단 방법에 관한 것이다. 일 구체예에 따른 심근 비대증 진단용 바이오마커 및 이를 포함하는 진단 키트 및 이를 이용한 심근 비대증 진단 방법에 따르면, 생물학적 시료로부터 심근 비대증을 판정하는데 유용하게 사용될 수 있고, 심근 비대증의 발병 기작을 규명하는 도구로 사용될 수 있다.
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