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    코카인 중독 특이적 바이오 마커
    7.
    发明授权
    코카인 중독 특이적 바이오 마커 有权

    公开(公告)号：KR102208012B1

    公开(公告)日：2021-01-27

    申请号：KR1020170176088

    申请日：2017-12-20

    Applicant: 가톨릭대학교 산학협력단

    Inventor： 김대진 ,  임창임 ,  방솔희 ,  최미란 ,  전지원 ,  이상훈

    IPC: C12Q1/68 ,  G01N33/68

    Abstract: 본발명은코카인의급성또는만성투여시발현이유의적으로변화하는바이오마커들에관한것으로, 본발명의바이오마커인 ARHGEF7, PTOV1, GTF2I, ADAM23, CDH2, GRIA1 (GRIA1X3, GRIA1X4), GRIA2 (GRIA2X6, GRIA2X7), HDAC5, HDAC10, NCAM1, NPY, SNCA, CCNG2, CDC7, CDH8, DLG3, DOCK3, NEUROD6, NEUROG2, SPEN, KDM2B (KDM2BX10, KDM2BX13), KIFAP3, RBM10, RBM14, TP53I11, WNT10B, MCM3AP, DRD1, DRD2, DRD3, GNAL, GNG7, LOC101865389, LOC101926461, PPP2R2B, ACHE, ADCY5, AKT3, KCNJ2, LOC101865389, LOC101926461, PLCB1, SLC18A3, SLC5A7, CAMK2A, EGLN2, ENO2, LOC101866179, LOC101866246, BAD, BCL2L1, CASP9, LOC101925175 및 TNFRSF1A는코카인의급성또는만성투여시 mRNA 및단백질의발현량이유의적으로상향또는하향조절되므로, 이들의발현패턴을통해코카인의급성또는만성노출에의한코카인중독및 의존성을확인할수 있다.

    가교된 이온 교환 막 및 그 제조방법
    8.
    发明公开
    가교된 이온 교환 막 및 그 제조방법 失效
    交联离子交换膜及其制备方法

    公开(公告)号：KR1020030038232A

    公开(公告)日：2003-05-16

    申请号：KR1020010069933

    申请日：2001-11-10

    Applicant: 한국과학기술연구원

    Inventor： 원종옥 ,  강용수 ,  홍성안 ,  오인환 ,  하흥용 ,  정범석 ,  전지원

    IPC: C08J5/22

    Abstract: PURPOSE: A crosslinked irreversible chemical gel film-type ion exchange membrane, its preparation method and a fuel cell containing the ion exchange membrane are provided, to reduce the effect of moisture and methanol on the hydrogen ion conductivity, to reduce the thickness and to improve the ion conductivity. CONSTITUTION: The ion exchange membrane is such that its crosslinking point is formed by the crosslinking reaction of a structural unit A selected from the groups represented by the formulas 1 and 2, and it comprises a structural unit B selected from the groups represented by the formula 3 or ArR7, wherein R1 to R5 are independent each another and are H, a phenyl group, an alkyl group of C1-C4, an alkylene group of C1-C4, an alkynyl group of C1-C4, a nitrile group or a functional group capable of inducing the condensation independently(i.e. epoxy, cyanate, ester and halogen); R6 is H or an alkyl group of C1-C4; Ar is a substituted or unsubstituted phenyl group(wherein the substituent is a phenyl group, an alkyl group of C1-C4, an alkylene group of C1-C4, or an alkynyl group of C1-C4); and R7 is -SO3H, -COOH or -P(O)(OR8)OH(wherein R8 is H or an alkyl group of C1-C4).

    Abstract translation: 目的：提供交联不可逆化学凝胶膜型离子交换膜及其制备方法和含有离子交换膜的燃料电池，以减少水分和甲醇对氢离子传导性的影响，减少厚度和改善 离子电导率。 构成：离子交换膜的交联点是通过选自由式1和2表示的基团的结构单元A的交联反应形成的，并且其包含选自由式 3或ArR7，其中R1至R5彼此独立，为H，苯基，C1-C4烷基，C1-C4亚烷基，C1-C4炔基，腈基或官能团 （即环氧基，氰酸酯，酯和卤素）; R6是H或C1-C4的烷基; Ar是取代或未取代的苯基（其中取代基是苯基，C1-C4的烷基，C1-C4的亚烷基或C1-C4的炔基）; 并且R 7是-SO 3 H，-COOH或-P（O）（OR 8）OH（其中R 8是H或C 1 -C 4的烷基）。

    분리능이 있는 수소 이온 교환 복합막, 복합 용액, 그제조방법 및 이를 포함하는 연료전지
    10.
    发明公开
    분리능이 있는 수소 이온 교환 복합막, 복합 용액, 그제조방법 및 이를 포함하는 연료전지 失效
    具有分离功能的氢离子复合膜，复合溶液，其制备方法和含有膜的燃料电池

    公开(公告)号：KR1020030024937A

    公开(公告)日：2003-03-28

    申请号：KR1020010054158

    申请日：2001-09-04

    Applicant: 한국과학기술연구원

    Inventor： 원종옥 ,  강용수 ,  오인환 ,  하흥용 ,  최상욱 ,  전지원 ,  정범석

    IPC: H01M8/02

    CPC classification number: H01M8/1051 ,  B01D69/141 ,  B01J47/12 ,  C08J5/2275 ,  C08J2323/06 ,  C08J2325/06 ,  H01M8/04197 ,  H01M8/1004 ,  H01M8/1011 ,  H01M8/1023 ,  H01M8/1039 ,  H01M8/1086 ,  Y02E60/523 ,  Y02P70/56

    Abstract: PURPOSE: An ion exchange composite membrane, its preparation method, a composite solution, and a fuel cell containing the membrane are provided, wherein the membrane intercepts methanol selectively without deterioration of the diffusion of hydrogen ions. CONSTITUTION: The ion exchange composite membrane comprises clay or organic clay dispersed into an ion conductive polymer film. Preferably the clay or organic clay is inserted into or coated on an ion conductive polymer film. The clay is at least one selected from the group consisting of pyrophylite-talc, smectite (montmorillonite), vermiculite, illite, mica and brittle mica group. The ion conductive polymer has at least one group selected from the group consisting of sulfonate, carboxylate, phosphate, imide, sulfonimide and sulfonamide, and is preferably nafion or sulfonated polystyrene-block-ply(ethylene-ran-butylene)-block-polystyrene. Preferably the fuel cell is a direct methanol fuel cell using methanol as a fuel.

    Abstract translation: 目的：提供一种离子交换复合膜，其制备方法，复合溶液和含有该膜的燃料电池，其中该膜截断甲醇选择性而不会降低氢离子的扩散。 构成：离子交换复合膜包括分散在离子传导性聚合物膜中的粘土或有机粘土。 优选将粘土或有机粘土插入或涂覆在离子导电聚合物膜上。 粘土是从由叶蜡石 - 滑石，蒙皂石（蒙脱石），蛭石，伊利石，云母和脆云母组成的组中选出的至少一种。 离子导电聚合物具有至少一种选自磺酸盐，羧酸盐，磷酸盐，酰亚胺，磺酰亚胺和磺酰胺的基团，并且优选为nafion或磺化聚苯乙烯 - 嵌段（乙烯 - 丁烯） - 嵌段 - 聚苯乙烯。 优选地，燃料电池是使用甲醇作为燃料的直接甲醇燃料电池。

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