Abstract:
본 발명은 빈쿨린 단백질을 포함하는, 나이관련 황반변성 진단용 바이오 마커 및 상기 마커를 이용하는, 나이관련 황반변성 진단용 키트, 진단 방법 및 치료용 물질의 스크리닝 방법에 관한 것이다. 상기 나이관련 황반변성 진단용 키트 및 진단 방법은, 환자의 혈장을 이용하는 새로운 면역학적 진단 도구로서, 민감도가 우수할 뿐만 아니라 생검을 이용하지 않고 혈장을 대상으로 간편하게 분석할 수 있어, 나이관련 황반변성의 진단에 유용하게 사용될 수 있다.
Abstract:
PURPOSE: A kit containing an antibody which specifically binds to melanotransferrin or a fragment thereof for diagnosing colon cancer is provided to ensure high sensitivity and simply analyze plasma without a biopsy. CONSTITUTION: A biomarker for diagnosing colon cancer contains melanotransferrin with an amino acid sequence of sequence number 1. The expression of melanotransferrin is relatively increased in blood, plasma, or serum from an individual with colon cancer. A kit for diagnosing colon cancer contains an antibody which specifically binds to melanotransferrin or a fragment thereof. A method for detecting melanotransferrin comprises: a step of contacting the antibody with a biological sample of an individual who is suspected to have colon cancer; and a step of detecting melanotransferrin from the biological sample.
Abstract:
PURPOSE: A method for diagnosing breast cancer using autoantibody is provided to prevent burden to a patient using blood as a test sample and to improve accuracy and density. CONSTITUTION: A vinculin autoantibody for diagnosing breast cancer specifically binds to vinculin protein of sequence number 2 or fragment thereof. A method or measuring vinculin autoantibody for diagnosing breast cancer comprises: a step of measuring vinculin autoantibody in a sample from an individual; a step of selecting individual with breast cancer in case of having lower autoantibody concentration than a healthy person. The sample is serum, plasma, or blood.