公开(公告)号：KR102170266B1

公开(公告)日：2020-10-27

申请号：KR1020130021481

申请日：2013-02-27

Applicant: 한국과학기술원

Inventor： 남윤성 ,  김지선 ,  오미화 ,  조성덕 ,  박재윤

IPC: A61K47/50 ,  A61K31/7105 ,  A61K31/713

公开(公告)号：KR1020140100640A

公开(公告)日：2014-08-18

申请号：KR1020130013354

申请日：2013-02-06

Applicant: 한국과학기술원

Inventor： 남윤성 ,  김지선 ,  박재윤

IPC: C08F28/00 ,  C08F297/00 ,  A61K47/48 ,  A61K9/127

CPC classification number: C08F273/00 ,  A61K9/10 ,  A61K47/34 ,  A61K47/50

Abstract: The present invention relates to an amphiphilic polymer which comprises a repeat unit of a specific chemical structure and is linked through amphiphilic polymers at the terminal end or comprises the repeat units of the specific chemical structure linked by the medium of amphiphilic polymers, and to a polymeric micelle composition including the amphiphilic polymer.

Abstract translation: 本发明涉及两亲性聚合物，其包含具有特定化学结构的重复单元，并且通过两末端聚合物在末端连接或包含通过两亲聚合物介质连接的特定化学结构的重复单元，以及聚合物 胶束组合物包括两亲性聚合物。

公开(公告)号：KR101452307B1

公开(公告)日：2014-10-23

申请号：KR1020130013354

申请日：2013-02-06

Applicant: 한국과학기술원

Inventor： 남윤성 ,  김지선 ,  박재윤

IPC: C08F28/00 ,  C08F297/00 ,  A61K47/48 ,  A61K9/127

Abstract: 본 발명은, 특정 화학 구조의 반복 단위를 포함하고 말단에 친수성 고분자 결합되거나, 상기 특정 화학 구조의 반복 단위가 친수성 고분자를 연결기로 하여 결합되어 있는 양친매성 고분자와, 이러한 양친매성 고분자를 포함하는 고분자 미셀 조성물에 관한 것이다.

公开(公告)号：KR1020140108439A

公开(公告)日：2014-09-11

申请号：KR1020130021481

申请日：2013-02-27

Applicant: 한국과학기술원

Inventor： 남윤성 ,  김지선 ,  오미화 ,  조성덕 ,  박재윤

IPC: C12N15/113 ,  A61K47/36 ,  A61K48/00

CPC classification number: C12N15/113 ,  A61K47/36 ,  A61K48/00

Abstract: The present invention relates to polysaccharides derivatives in which siRNA is grafted, a gene carrier comprising the same, and a method for manufacturing the same. In the siRNA carrier according to the present invention, since polysaccharides is located on the surface of the carrier, the dispersion stability is high so the siRNA carrier can be stable in the body for a long time without aggregation, thereby effectively suppressing the protein expression of a target gene, and the siRNA can be easily restored into the original structure of siRNA having a bioactivity in the cell after entering the body. Also, the present invention dramatically improves therapeutic effects by introducing functional molecules appropriate for target therapies according to various target diseases using the polysaccharides functional group located on the surface of the siRNA carrier, thereby being able to be used in various fields of gene therapy using siRNAs.

Abstract translation: 本发明涉及其中接枝siRNA的多糖衍生物，包含其的基因载体及其制备方法。 在本发明的siRNA载体中，由于多糖位于载体的表面，所以分散稳定性高，因此siRNA载体长时间稳定而无聚集，有效地抑制了蛋白质的表达 靶基因，并且siRNA可以容易地恢复到进入身体后在细胞中具有生物活性的siRNA的原始结构。 此外，本发明通过使用位于siRNA载体表面上的多糖官能团，根据各种靶疾病引入适合于靶治疗的功能分子，从而显着改善治疗效果，从而能够用于使用siRNA的基因治疗的各种领域 。