公开(公告)号：KR100915671B1

公开(公告)日：2009-09-04

申请号：KR1020070081959

申请日：2007-08-14

Applicant: 한국과학기술원

Inventor： 이희승 ,  옥태동 ,  전아람

IPC: C07D307/32

Abstract: 본 발명은 다양한 리그난(Lignans) 유도체 및 γ아미노부티르산(GABA, γ-aminobutyric acid) 유도체의 제조에 유용한 중간체인 치환된 γ-부티로락톤의 광학선택적 제조방법에 관한 것으로, (R) 또는 (S)의 에틸-2-옥소-3-옥사-바이사이클로[3.1.0]헥산-1-카복실레이트(ethyl 2-oxo-3-oxa-bicyclo[3.1.0]hexane-1-carboxylate)를 출발물질로 하여 다양한 친핵체와 반응시켜 제조되는 치환된 γ-부티로락톤의 광학선택적 제조방법에 관한 것이다.

公开(公告)号：KR1020120022603A

公开(公告)日：2012-03-12

申请号：KR1020110077420

申请日：2011-08-03

Applicant: 한국과학기술원

Inventor： 이희승 ,  권선범 ,  전아람 ,  유성현 ,  정임식

IPC: C07C229/14 ,  C07C271/24 ,  C07C269/08 ,  C07B63/00

CPC classification number: Y02P20/55 ,  C07C271/24 ,  C07C269/08

Abstract: PURPOSE: A manufacturing method of a self-assembly of peptide is provided to form a self-assembly of peptide with a specific structure according to a hydrogen bond, and hydrophobicity between the surfaces of helix in solvophobic environment like water-soluble solvent. CONSTITUTION: A self-assembly of peptide is in chemical formula 1. In chemical formula 1, R1 is H or a protective group, R2 is OH, OR3, NR4R5 or a protective group, R3 is C1-6 alkyl, and C5-12 aryl or benzyl, R4 and R5 is respectively hydrogen, C1-6 alkyl, and C5-12 aryl or benzyl, and n is 2-20. A manufacturing method of a self-assembly of peptide comprises: a step of adding a compound in chemical formula 1 into solvent, and mixing the same; a step of forming precipitate of the manufactured solution by neglecting; a step of removing residue solvent by filtering the precipitate and cleaning the precipitate.

Abstract translation: 目的：提供肽的自组装的制造方法，以形成具有根据氢键的特定结构的肽的自组装，以及溶剂化环境中的螺旋表面如水溶性溶剂之间的疏水性。 构成：肽的自组装在化学式1中。在化学式1中，R1是H或保护基，R2是OH，OR3，NR4R5或保护基，R3是C1-6烷基，C5-12 芳基或苄基，R4和R5分别是氢，C1-6烷基和C5-12芳基或苄基，n是2-20。 肽的自组装的制造方法包括：将化学式1中的化合物加入溶剂中并混合的步骤; 通过忽略制造溶液的沉淀的步骤; 通过过滤沉淀物并清除沉淀物除去残留溶剂的步骤。

公开(公告)号：KR101269589B1

公开(公告)日：2013-06-05

申请号：KR1020110077420

申请日：2011-08-03

Applicant: 한국과학기술원

Inventor： 이희승 ,  권선범 ,  전아람 ,  유성현 ,  정임식

IPC: C07C229/14 ,  C07C271/24 ,  C07C269/08 ,  C07B63/00

CPC classification number: Y02P20/55

Abstract: 본 발명은, 특정형태의 자기조립 집합체를 형성하는 화합물을 제조하기 위한 것이다. 또한 본 발명은 상기 화합물을 사용하여 자기조립 집합체를 제조하는 방법을 제공하기 위한 것이다.

公开(公告)号：KR1020090017316A

公开(公告)日：2009-02-18

申请号：KR1020070081959

申请日：2007-08-14

Applicant: 한국과학기술원

Inventor： 이희승 ,  옥태동 ,  전아람

IPC: C07D307/32

Abstract: An enantioselective synthesis of alpha,beta-substituted gamma-butyrolactones is provided to improve the optical isomer purity of gamma-butyrolactones in which beta-site is substituted by various substituents, so that the substituted gamma-butyrolactones is useful as intermediate for production of lignan or GABA(gamma-aminobutyric acid) derivative. The substituted gamma-butyrolactones represented by the chemical formula(1) or (2) is enantioselectively prepared by performing nucleophilic addition of the compound represented by the chemical formula(5) into the compound represented by the chemical formula(3) or (4) according to the reaction equation(1) or (2), wherein Nu is C1-C10 linear or branched saturated or unsaturated alkyl, C3-C10 cycloalkyl, substituted or unsubstituted phenyl, azide, cyano or phthalimide group; A is potassium(K), sodium(Na) or MgX; and Mg is magnesium and X is chlorine(Cl) or bromine(Br).

Abstract translation: 提供α，β-取代的γ-丁内酯的对映选择性合成，以改善其中β位被各种取代基取代的γ-丁内酯的旋光异构体纯度，使得取代的γ-丁内酯可用作生产木脂素的中间体 或GABA（γ-氨基丁酸）衍生物。 由化学式（1）或（2）表示的取代的γ-丁内酯通过将由化学式（5）表示的化合物亲和加成到由化学式（3）或（4）表示的化合物中进行对映选择性地制备， 根据反应式（1）或（2），其中Nu是C1-C10直链或支链饱和或不饱和的烷基，C3-C10环烷基，取代或未取代的苯基，叠氮基，氰基或邻苯二甲酰亚胺基团; A是钾（K），钠（Na）或MgX; Mg是镁，X是氯（Cl）或溴（Br）。