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公开(公告)号：KR1020170026794A
公开(公告)日：2017-03-09
申请号：KR1020150121522
申请日：2015-08-28
Applicant: 한국과학기술원
IPC: C07K7/02
Abstract: 본발명은속이빈 특정형태를갖는펩타이드자기조립집합체및 이의제조방법에관한것으로, 본발명에따른 3 배위의대칭성을가진삼각뿔형태의자기조립집합체는기존펩타이드의자기조립집합체에서는존재하지않는내부빈공간이형성되고, 이에상기공간에다양한형광재료의캡슐화및 선택적방출실험을통해확인하였으므로분자저장재료나약물전달물질등으로유용하게사용될수 있는효과가있다.
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公开(公告)号：KR101839987B1
公开(公告)日：2018-03-20
申请号：KR1020150188482
申请日：2015-12-29
Applicant: 한국과학기술원
IPC: C07C229/14 , C07C269/08 , C07C271/24 , C07B63/00
Abstract: 본발명은주자성의펩타이드자기조립집합체및 이의제조방법에관한것이다. 본발명에따른주자성자기조립집합체인폴덱쳐는외부자기장에의해스스로정렬되며, 자기장의방향에따라정렬방향이바뀌고, 낮은자기장에서도폴덱쳐들이감응하며정렬해수용액상에서실시간회전운동도가능한주자성을나타내므로, 펩타이드자기나침반, 자극반응성분자기계, 유기나노물질의움직임제어등 다양한응용연구분야에유용하게사용될수 있다.
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公开(公告)号：KR1020120022603A
公开(公告)日：2012-03-12
申请号：KR1020110077420
申请日：2011-08-03
Applicant: 한국과학기술원
IPC: C07C229/14 , C07C271/24 , C07C269/08 , C07B63/00
CPC classification number: Y02P20/55 , C07C271/24 , C07C269/08
Abstract: PURPOSE: A manufacturing method of a self-assembly of peptide is provided to form a self-assembly of peptide with a specific structure according to a hydrogen bond, and hydrophobicity between the surfaces of helix in solvophobic environment like water-soluble solvent. CONSTITUTION: A self-assembly of peptide is in chemical formula 1. In chemical formula 1, R1 is H or a protective group, R2 is OH, OR3, NR4R5 or a protective group, R3 is C1-6 alkyl, and C5-12 aryl or benzyl, R4 and R5 is respectively hydrogen, C1-6 alkyl, and C5-12 aryl or benzyl, and n is 2-20. A manufacturing method of a self-assembly of peptide comprises: a step of adding a compound in chemical formula 1 into solvent, and mixing the same; a step of forming precipitate of the manufactured solution by neglecting; a step of removing residue solvent by filtering the precipitate and cleaning the precipitate.
Abstract translation: 目的：提供肽的自组装的制造方法，以形成具有根据氢键的特定结构的肽的自组装，以及溶剂化环境中的螺旋表面如水溶性溶剂之间的疏水性。 构成：肽的自组装在化学式1中。在化学式1中，R1是H或保护基，R2是OH，OR3，NR4R5或保护基，R3是C1-6烷基，C5-12 芳基或苄基，R4和R5分别是氢，C1-6烷基和C5-12芳基或苄基，n是2-20。 肽的自组装的制造方法包括：将化学式1中的化合物加入溶剂中并混合的步骤; 通过忽略制造溶液的沉淀的步骤; 通过过滤沉淀物并清除沉淀物除去残留溶剂的步骤。
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公开(公告)号：KR1020170078936A
公开(公告)日：2017-07-10
申请号：KR1020150188482
申请日：2015-12-29
Applicant: 한국과학기술원
IPC: C07C229/14 , C07C269/08 , C07C271/24 , C07B63/00
Abstract: 본발명은주자성의펩타이드자기조립집합체및 이의제조방법에관한것이다. 본발명에따른주자성자기조립집합체인폴덱쳐는외부자기장에의해스스로정렬되며, 자기장의방향에따라정렬방향이바뀌고, 낮은자기장에서도폴덱쳐들이감응하며정렬해수용액상에서실시간회전운동도가능한주자성을나타내므로, 펩타이드자기나침반, 자극반응성분자기계, 유기나노물질의움직임제어등 다양한응용연구분야에유용하게사용될수 있다.
Abstract translation: 本发明涉及自组装的自组装肽及其制备方法。 跑者圣自组装集合体保罗dekchyeo根据本发明由外部磁场排列本身，根据磁场的方向变化的取向方向，并且即使在低磁场具有敏感和对准极dekchyeo也可以在水溶液中转轮城堡实时旋转 可用于肽磁罗盘，反应活性分子机器，有机纳米材料的运动控制等各种应用领域。
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Patent Agency Ranking
公开(公告)号：KR1020100052266A
公开(公告)日：2010-05-19
申请号：KR1020080111212
申请日：2008-11-10
Applicant: 한국과학기술원
IPC: C07D239/08
CPC classification number: Y02P20/55
Abstract: PURPOSE: A novel PNA(peptide nucleic acid) and hybridized PNA oligomer using the same is provided to selectively bind to RNA and to treat and diagnose various diseases targeting RNA. CONSTITUTION: A gamma3-PNA monomer molecule is denoted by chemical formula 18. A method for preparing gamma3-PNA comprises: a step of performing ring-opening reaction of (R)-azidomethyl gamma-butylolactone(chemical formula 1) to obtain a compound of chemical formula 2; a step of reacting nucleic acid with the compound of chemical formula 2 or performing protection reaction of exocyclic amino or hydroxyl group of nucleic acid after reacting nucleic acid with the compound of chemical formula 2; a step of reducing azide from the compound which is bound to nucleic acid; and a step of attaching a protection group to obtain a compound of chemical formula 19.
Abstract translation: 目的：提供新型PNA（肽核酸）和使用其的杂交的PNA寡聚体以选择性结合RNA并治疗和诊断靶向RNA的各种疾病。 构成：γ3-PNA单体分子由化学式18表示。制备γ3-PNA的方法包括：（R） - 叠氮基甲基γ-丁内酯（化学式1）进行开环反应的步骤，得到化合物 化学式2; 在核酸与化学式2的化合物反应后，使核酸与化学式2的化合物反应或进行核酸的环外氨基或羟基的保护反应的步骤; 从与核酸结合的化合物中还原叠氮化物的步骤; 以及附着保护基以获得化学式19的化合物的步骤。
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公开(公告)号：KR1020090017822A
公开(公告)日：2009-02-19
申请号：KR1020070082293
申请日：2007-08-16
Applicant: 한국과학기술원
IPC: C07D307/93
Abstract: A method for preparing the crystalline bicyclic lactone is provided to easily obtain the optically pure single crystal structure bicyclic lactone having purity of 99%ee. The method for preparing single crystal structure of bicyclic lactone comprises the steps of: reacting epochlorohydrin with malonic acid ester; and subjecting the reaction mixture with vacuum distillation and low temperature treatment to prepare (1R,5S)-alkyl-2-iodine-3-oxabicyclo [3.1.0] hexane-1-carboxylate or (1R,5S)-alkyl-2-iodine-3-oxabicyclo [3.1.0] hexane-1-carboxylate.
Abstract translation: 提供了制备结晶二环内酯的方法，以便容易地获得纯度为99％ee的光学纯单晶结构双环内酯。 制备双环内酯单晶结构的方法包括以下步骤：使环丙氯酚与丙二酸酯反应; （1R，5S） - 烷基-2-碘-3-氧杂双环[3.1.0]己烷-1-羧酸酯或（1R，5S） - 烷基-2- 碘-3-氧杂双环[3.1.0]己烷-1-羧酸叔丁酯。
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公开(公告)号：KR101736206B1
公开(公告)日：2017-05-18
申请号：KR1020150029279
申请日：2015-03-02
Applicant: 한국과학기술원
IPC: A61K47/08 , A61K47/48 , A61K31/7088 , A61K49/00 , C07C61/06
Abstract: 본발명은비등방성표면특성을갖는자기조립집합체, 이의제조방법및 용도에관한것이다. 본발명의비등방성표면특성을갖는자기조립집합체는일 말단에친수성작용기를갖는산성형의단량체를이용하고소수성면과우선적으로상호작용하는계면활성제을첨가함으로서성장방향을조절하여성장시킴으로써크기및/또는모양이조절되고특정면에작용기가선택적으로분포되어각 면에서상이한표면특성을가지며, 이로인해면-선택적수식이가능한나노/마이크로크기의구조물을제공할수 있다. 또한, 본발명의자기조립집합체는생체적합성펩티드-유사물질로부터제조되므로의약분야에도폭넓게이용될수 있다.
Abstract translation: 本发明涉及具有双轴表面性质的自组装集合体，该自组装集合体的制造方法及其用途。 具有本发明通过生长的各向异性表面特征，通过添加表面活性剂使用一个终端上形成的酸的单体具有亲水性官能团和控制生长方向上的自组装集合体hwalseongjeeul与疏水性表面和所述第一大小和/或交互的 形状被调整和官能基团任选地分布在特定表面具有在每一侧上一个不同的表面特性，如果因为这个 - 可以提供选择性的式纳米/微米尺度的结构成为可能。 此外，由于本发明的自组装聚集体由生物相容性肽样材料制备，因此可以广泛用于制药领域。
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公开(公告)号：KR101269589B1
公开(公告)日：2013-06-05
申请号：KR1020110077420
申请日：2011-08-03
Applicant: 한국과학기술원
IPC: C07C229/14 , C07C271/24 , C07C269/08 , C07B63/00
CPC classification number: Y02P20/55
Abstract: 본 발명은, 특정형태의 자기조립 집합체를 형성하는 화합물을 제조하기 위한 것이다. 또한 본 발명은 상기 화합물을 사용하여 자기조립 집합체를 제조하는 방법을 제공하기 위한 것이다.
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公开(公告)号：KR1020090017316A
公开(公告)日：2009-02-18
申请号：KR1020070081959
申请日：2007-08-14
Applicant: 한국과학기술원
IPC: C07D307/32
Abstract: An enantioselective synthesis of alpha,beta-substituted gamma-butyrolactones is provided to improve the optical isomer purity of gamma-butyrolactones in which beta-site is substituted by various substituents, so that the substituted gamma-butyrolactones is useful as intermediate for production of lignan or GABA(gamma-aminobutyric acid) derivative. The substituted gamma-butyrolactones represented by the chemical formula(1) or (2) is enantioselectively prepared by performing nucleophilic addition of the compound represented by the chemical formula(5) into the compound represented by the chemical formula(3) or (4) according to the reaction equation(1) or (2), wherein Nu is C1-C10 linear or branched saturated or unsaturated alkyl, C3-C10 cycloalkyl, substituted or unsubstituted phenyl, azide, cyano or phthalimide group; A is potassium(K), sodium(Na) or MgX; and Mg is magnesium and X is chlorine(Cl) or bromine(Br).
Abstract translation: 提供α，β-取代的γ-丁内酯的对映选择性合成，以改善其中β位被各种取代基取代的γ-丁内酯的旋光异构体纯度，使得取代的γ-丁内酯可用作生产木脂素的中间体 或GABA（γ-氨基丁酸）衍生物。 由化学式（1）或（2）表示的取代的γ-丁内酯通过将由化学式（5）表示的化合物亲和加成到由化学式（3）或（4）表示的化合物中进行对映选择性地制备， 根据反应式（1）或（2），其中Nu是C1-C10直链或支链饱和或不饱和的烷基，C3-C10环烷基，取代或未取代的苯基，叠氮基，氰基或邻苯二甲酰亚胺基团; A是钾（K），钠（Na）或MgX; Mg是镁，X是氯（Cl）或溴（Br）。
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