BC200 RNA에 대한 siRNA를 포함하는 종양전이 억제용 약학조성물
    1.
    发明公开
    BC200 RNA에 대한 siRNA를 포함하는 종양전이 억제용 약학조성물 有权
    用于抑制包含BC200 RNA的SIRNA的METASTASIS的药物组合物

    公开(公告)号:KR1020130013675A

    公开(公告)日:2013-02-06

    申请号:KR1020110075419

    申请日:2011-07-28

    Abstract: PURPOSE: An siRNA which suppresses BC200 RNA activation and a pharmaceutical composition containing the same for suppressing tumor metastasis are provided to inhibit cancer cell migration and metastasis and to effectively treat cancer. CONSTITUTION: An siRNA which suppresses BC200 RNA(sequence number 1) activation has a base sequence of 5'-GUAACUUCCCUCAAAGCAA-3'(sequence number 2) or 5'- UUGCUUUGAGGGAAGUUAC-3'(sequence number 3). The siRNA additionally contains a dTdT base sequence at the 3'-end of the siRNA. A vector contains a polynucleotide which enables transcription of shRNA. The vector transcribes shRNA in a cell and the transcribed shRNA is converted into siRNA by cleavage using RNase III. A pharmaceutical composition for suppressing tumor metastasis contains the vector as an active ingredient. The composition additionally contains a pharmaceutically acceptable carrier. [Reference numerals] (AA) Negative control group siRNA

    Abstract translation: 目的:提供抑制BC200 RNA活化的siRNA和抑制肿瘤转移的药物组合物,以抑制癌细胞迁移和转移并有效治疗癌症。 构成:抑制BC200 RNA(序列号1)活化的siRNA具有5'-GUAACUUCCCUCAAAGCAA-3'(序列号2)或5'UUGCUUGAGGGAAGUUAC-3'(序列号3)的碱基序列。 siRNA另外在siRNA的3'端含有dTdT碱基序列。 载体含有能够转录shRNA的多核苷酸。 载体在细胞中转录shRNA,转录的shRNA通过使用核糖核酸酶III的切割转化成siRNA。 用于抑制肿瘤转移的药物组合物含有作为活性成分的载体。 该组合物另外含有药学上可接受的载体。 (AA)阴性对照组siRNA

    RNA에 특이적으로 결합하는 항체
    2.
    发明公开
    RNA에 특이적으로 결합하는 항체 有权
    RNA特异性结合抗体

    公开(公告)号:KR1020150108997A

    公开(公告)日:2015-10-01

    申请号:KR1020140031768

    申请日:2014-03-18

    Abstract: 본발명은 BC200 RNA 에특이적으로결합하는항체또는항원결합단편, 상기항체또는항원결합단편을코딩하는핵산분자, 이를포함하는 BC200 RNA 탐지용조성물, 키트, 상기항체또는이의항원결합단편을이용한시료내 BC200 RNA 탐지방법, 상기항체또는이의항원결합단편을포함하는 BC200 RNA 관련질환진단용조성물및 예방또는치료용약학조성물에관한것이다.

    Abstract translation: 本发明涉及能够特异性结合BC200 RNA或其抗原结合片段的抗体,编码抗体或其抗原结合片段的多核苷酸,用于检测包括该多核苷酸的BC200 RNA的组合物和试剂盒,用于检测BC200的方法 使用抗体或其抗原结合片段的样品中的RNA,以及用于诊断的组合物或用于预防或治疗包括所述抗体或其抗原结合片段的BC200 RNA相关疾病的药物组合物。

    RNA에 특이적으로 결합하는 항체 및 이의 선별방법
    4.
    发明公开
    RNA에 특이적으로 결합하는 항체 및 이의 선별방법 有权
    RNA特异性结合抗体及其选择方法

    公开(公告)号:KR1020140085815A

    公开(公告)日:2014-07-08

    申请号:KR1020120155487

    申请日:2012-12-27

    Abstract: The present invention relates to a selection method of RNA-binding antibodies and to an antibody specifically binding to BC200 RNAs. The selection method of the present invention can be suitably used for manufacturing human antibodies which recognize functional RNA structures, and the antibody specifically binding to BC200 RNA recognizes BC200 RNAs or controls actions thereof, thereby can be suitably applied in related medical fields.

    Abstract translation: 本发明涉及RNA结合抗体和特异性结合BC200 RNA的抗体的选择方法。 本发明的选择方法可以适用于制造识别功能性RNA结构的人抗体,特异性结合BC200 RNA的抗体识别BC200 RNA或其控制作用,因此可以适用于相关医疗领域。

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